Imaging of Central Neurocytomas

Donoho, Daniel A.; Zada, Gabriel

doi:10.1016/j.nec.2014.09.012

Cited by 28 publications

(12 citation statements)

References 64 publications

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“…Computed tomography images demonstrate a heterogeneously hyperdense, enhancing mass. CN is typically isointense, iso-hyperintense and moderately hyperintense on T1-, T2-, and contrast enhanced magnetic resonance imaging, respectively[4811151718192021]. …”

Section: Introductionmentioning

confidence: 99%

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Bui

Lagman

Chung

et al. 2017

Brain Tumor Res Treat

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Central neurocytoma (CN) typically presents as an intraventricular mass causing obstructive hydrocephalus. The first line of treatment is surgical resection with adjuvant conventional radiotherapy. Stereotactic radiosurgery (SRS) was proposed as an alternative therapy for CN because of its lower risk profile. The objective of this systematic analysis is to assess the efficacy of SRS for CN. A systematic analysis for CN treated with SRS was conducted in PubMed. Baseline patient characteristics and outcomes data were extracted. Heterogeneity and publication bias were also assessed. Univariate and multivariate linear regressions were used to test for correlations to the primary outcome: local control (LC). The estimated cumulative rate of LC was 92.2% (95% confidence interval: 86.5-95.7%, p<0.001). Mean follow-up time was 62.4 months (range 3-149 months). Heterogeneity and publication bias were insignificant. The univariate linear regression models for both mean tumor volume and mean dose were significantly correlated with improved LC (p<0.001). Our data suggests that SRS may be an effective and safe therapy for CN. However, the rarity of CN still limits the efficacy of a quantitative analysis. Future multi-institutional, randomized trials of CN patients should be considered to further elucidate this therapy.

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Section: Introductionmentioning

confidence: 99%

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Bui

Lagman

Chung

et al. 2017

Brain Tumor Res Treat

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“…Intraventricular and extraventricular CN are equally frequent in 20–40-year-old men and women. [4615] The symptoms of extraventricular CN are generally nonspecific, including headache, dizziness, nausea, vision changes, and symptoms related to focal compression or intracranial hypertension. [4671315] The most common sites of extraventricular CN are the frontal lobe (30–46%), parietal lobe (11–23%), temporal lobe (13–20%), occipital lobe (2–11%), and cerebellum (6–9%).…”

Section: Discussionmentioning

confidence: 99%

“…[4615] The symptoms of extraventricular CN are generally nonspecific, including headache, dizziness, nausea, vision changes, and symptoms related to focal compression or intracranial hypertension. [4671315] The most common sites of extraventricular CN are the frontal lobe (30–46%), parietal lobe (11–23%), temporal lobe (13–20%), occipital lobe (2–11%), and cerebellum (6–9%). [27111315] Other less common locations include the thalamus, corpus callosum, sella, hypothalamus, pineal region, pons, spinal cord, and sphenoid wing.…”

Section: Discussionmentioning

confidence: 99%

“…in 1982 as an intraventricular tumor exhibiting histological similarities to oligodendrogliomas. [6] In 2000, the World Health Organization recognized the existence of extraventricular neurocytomas which received their own classification in 2007, although the intraventricular and extraventricular forms have strong cellular similarity and are both considered grade II tumors. [19] Approximately 0.1–1.0% of central nervous system neoplasms are CN, and approximately 10% of CN are considered extraventricular at presentation,[1] although there are <200 cases reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Neurocytoma mimicking macroadenoma

Nery¹,

Filho²,

Costa³

et al. 2019

Surg Neurol Int

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Background:Intraventricular and extraventricular central neurocytomas (CN) are equally frequent among 20–40-year-old men and women. However, sellar and suprasellar extraventricular CN are extremely rare, with only 12 reported cases.Case Description:The authors report the case of a Brazilian 27-year-old man who presented with progressive vision loss during the last 4 years and serious bilateral keratoconus. We also review the epidemiological, clinical, radiological, pathological, and treatment features of the 12 reported cases. The patient developed left amaurosis and right temporal hemianopsia after undergoing bilateral corneal transplantation, which was detected during campimetry testing, and subsequently underwent magnetic resonance imaging, which revealed a huge hypophyseal tumor. Endocrinological evaluation revealed complete loss of pituitary function. The patient was referred to our department and underwent a two-step surgery (using transsphenoidal approach and cranio-orbital zygomatic approach) based on the diagnosis of an extraventricular central nervous system neurocytoma. Tumor removal was successful, and the patient was discharged at 3 weeks after admission to our department.Conclusion:Although extraventricular neurocytomas of the brain are rare, careful preoperative consideration of its anatomy, pathophysiological features, and radiological features can enhance the treatment outcomes.

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“…The rarity of this tumor has impeded standardization of treatment. Prognosis is excellent after gross surgical resection, hence most studies recommend surgery as the primary modality [2][3][4][5][6][7][8][9][10][11]. Choosing the endoscopic approach over open surgery is dependent on tumor location and size [10, [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Gross Total Endoscopic Resection of a Left Lateral Ventricle Central Neurocytoma in an 18-Year-Old Filipino Male: A Case Report

Mercado¹,

Leong²,

Mariano³

et al. 2022

SCR

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Central neurocytomas are rare intraventricular tumors of neuronal origin that most commonly affect young adults. These tumors have a benign course and excellent prognosis after surgery. We present the first documented case of an 18-year-old healthy Filipino male presenting with new-onset generalized seizures and a heterogeneously enhancing left lateral ventricle tumor on imaging. The tumor was completely excised through endoscopic surgery, after which the patient made a complete recovery. Proper selection of cases, coupled with neurosurgeon expertise, solidifies endoscopic surgery as a safe and reasonable approach to achieve gross total resection of an intraventricular tumor.

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Imaging of Central Neurocytomas

Cited by 28 publications

References 64 publications

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma

Neurocytoma mimicking macroadenoma

Gross Total Endoscopic Resection of a Left Lateral Ventricle Central Neurocytoma in an 18-Year-Old Filipino Male: A Case Report

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