Imaging of Cerebral Ischemia

Nour, May; Liebeskind, David S

doi:10.1016/j.ncl.2013.07.005

Cited by 13 publications

(3 citation statements)

References 70 publications

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“…However, prior studies used MRI modality for assessing the ischemic/infarct volume because they recruited post-ischemic stroke patients (3 weeks-6 months after stroke onset). Therefore, MRI was chosen due to its superiority to detect ischemic lesion in subacute or chronic stroke [49,50]. Nonetheless, MRI is more cost-effective and time consuming than CT scan.…”

Section: Plos Onementioning

confidence: 99%

Higher level of acute serum VEGF and larger infarct volume are more frequently associated with post-stroke cognitive impairment

et al. 2020

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Section: Plos Onementioning

confidence: 99%

Higher level of acute serum VEGF and larger infarct volume are more frequently associated with post-stroke cognitive impairment

et al. 2020

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“…These hyperintensities aid in the differentiation of acute from chronic infarcts and guide treatment decisions. In conditions like small vessel disease, hyperintensities in the deep white matter indicate microvascular changes and contribute to assessing cerebrovascular risk factors [ 39 ].…”

Section: Reviewmentioning

confidence: 99%

Unveiling the Intricacies: A Comprehensive Review of Magnetic Resonance Imaging (MRI) Assessment of T2-Weighted Hyperintensities in the Neuroimaging Landscape

Dhabalia,

Kashikar,

Parihar

et al. 2024

Cureus

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T2-weighted hyperintensities in neuroimaging represent areas of heightened signal intensity on magnetic resonance imaging (MRI) scans, holding crucial importance in neuroimaging. This comprehensive review explores the T2-weighted hyperintensities, providing insights into their definition, characteristics, clinical relevance, and underlying causes. It highlights the significance of these hyperintensities as sensitive markers for neurological disorders, including multiple sclerosis, vascular dementia, and brain tumors. The review also delves into advanced neuroimaging techniques, such as susceptibility-weighted and diffusion tensor imaging, and the application of artificial intelligence and machine learning in hyperintensities analysis. Furthermore, it outlines the challenges and pitfalls associated with their assessment and emphasizes the importance of standardized protocols and a multidisciplinary approach. The review discusses future directions for research and clinical practice, including the development of biomarkers, personalized medicine, and enhanced imaging techniques. Ultimately, the review underscores the profound impact of T2-weighted hyperintensities in shaping the landscape of neurological diagnosis, prognosis, and treatment, contributing to a deeper understanding of complex neurological conditions and guiding more informed and effective patient care.

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“…Эти обследования могут выявить атеросклеротические, стенозирующие изменения сосудов, аневризматические поражения, тромбозы вен. При обследовании микроангиопатии, где размеры сосудов составляют от 40 до 200 микрон, можно ограничиться одним методом исследования -МРТ в режиме Т2 градиентного эхо, где глубинные диффузно-морфологические изменения структур головного мозга могут быть выявлены [39][40][41][42].…”

Section: результаты и обсуждениеunclassified

Chronic cerebral ischemia: review of published works, pathogenetic approaches to therapy

Zharkinbekova

2020

Medicine

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Chronic сеrebral ischemia is one of the leading causes of morbidity, mortality and disability in the Republic of Kazakhstan. According to the data from Ministry of Healthcare of the Republic of Kazakhstan, the overall morbidity of the country’s population due to diseases of the circulatory system registered in health care organizations has increased almost three times from 1998 to 2017 over the past 20 years. According to world publications, on average, the incidence of Chronic сеrebral ischemia in the world is relatively high among the elderly, occurring in two-thirds of people over 65 years of age. It is also observed in 50% of people aged 50 to 65 years and in 25% of people aged 45 to 50 years. Purpose. To review of epidemiological data, risk factors, causes, pathogenetic mechanisms, diagnostic algorithms and principles of treatment of Chronic сеrebral ischemia. Material and methods. The literature review on Chronic сеrebral ischemia data was conducted using the Pubmed search engine in Medline electronic databases from 2009 to 2019. Results and discussion. A total of 45 research papers were included. This review examines epidemiological data, risk factors, causes, pathogenetic mechanisms, diagnostic algorithms and principles of therapy for Chronic сеrebral ischemia disease. In the etiopathogenesis of Chronic сеrebral ischemia, a significant part is played by the combination of risk factors known as vascular comorbidity and being the main cause of deaths. Vascular comorbidity is characterized by the involvement into a single pathological process of all risk factors that form Chronic сеrebral ischemia, which lead to a change in cerebral circulation with hypoxia of the brain substance and a cascade of biochemical changes, and subsequently results in diffuse, multi-focal changes in the brain substance. In a case of comorbidity of the atherosclerotic process with dyslipidemia, narrowing of the lumen of the arteries with an increase in the permeability of their wall membranes can be observed, with further damage to the endothelium, activation of synthesis by leukocytes, platelets, endotheliocytes of chemotaxis factors, kinins, growth factors, with the accumulation of active oxygen, peroxidation with the formation of oxidative stress. Chronic сеrebral ischemia therapy with vascular comorbidity, in which all risk factors are В тексте переправлены стилистические и ортографические ошибки. involved in a single pathological process, provides the prevention of polypragmasia, and the assignment of certain pathogenetic drugs aimed at the same pathogenesis that leads to the formation of Chronic сеrebral ischemia. Conclusion. It is most rational to use an antioxidant/antihypoxant in therapy. Such pathogenetic drugs include antioxidant therapy. Among other antioxidants/antihypoxants used in routine practice, Mexidol (ethylmethylhydroxypyridine succinate) is characterized with the strongest evidence base. Keyword: chronic brain ischemia, chronic cerebral circulatory insufficiency, vascular comorbidity, ethylmethylhydroxypyridine succinate, Mexidol.

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Imaging of Cerebral Ischemia

Cited by 13 publications

References 70 publications

Higher level of acute serum VEGF and larger infarct volume are more frequently associated with post-stroke cognitive impairment

Higher level of acute serum VEGF and larger infarct volume are more frequently associated with post-stroke cognitive impairment

Unveiling the Intricacies: A Comprehensive Review of Magnetic Resonance Imaging (MRI) Assessment of T2-Weighted Hyperintensities in the Neuroimaging Landscape

Chronic cerebral ischemia: review of published works, pathogenetic approaches to therapy

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