2016
DOI: 10.1177/2050640616636620
|View full text |Cite
|
Sign up to set email alerts
|

Imaging of intestinal fibrosis: current challenges and future methods

Abstract: Crohn's disease (CD) activity assessments are dominated by inflammatory changes without discrete measurement of the coexisting fibrotic contribution to total bowel damage. Intestinal fibrosis impacts the development of severe structural complications and the overall natural history of CD. Measuring intestinal fibrosis is challenging and existing methods of disease assessment are unable to reliably distinguish fibrosis from inflammation. Both the immediate clinical need to measure fibrosis for therapeutic decis… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
28
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 33 publications
(28 citation statements)
references
References 39 publications
0
28
0
Order By: Relevance
“…Future prospective work could determine whether advanced bowel imaging techniques to identify fibrosis, including MR-based diffusion weighted imaging (DWI), magnetic transference (MT-MRI) sequences, and both MR and ultrasound-based elastography can improve similar predictive models 22 . Further exploration is needed to determine whether CRP, ESR, or fecal calprotectin can outperform platelets in predicting clinical outcomes in stricturing CD.…”
Section: Discussionmentioning
confidence: 99%
“…Future prospective work could determine whether advanced bowel imaging techniques to identify fibrosis, including MR-based diffusion weighted imaging (DWI), magnetic transference (MT-MRI) sequences, and both MR and ultrasound-based elastography can improve similar predictive models 22 . Further exploration is needed to determine whether CRP, ESR, or fecal calprotectin can outperform platelets in predicting clinical outcomes in stricturing CD.…”
Section: Discussionmentioning
confidence: 99%
“…However, this study was limited to differentiating severe, end-stage fibrosis. There has been no prominent evidence to support the clinical significance of these approaches [17].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, prospective study of optimal balloon inflation time, frequency of dilations, and number of dilation that can be safely performed at one time in a given stricture are needed. Both enterography-based techniques, as well as novel methods to assess the mechanical properties of intestine including stiffness imaging using MR, ultrasound, and photo-acoustic imaging, may offer additional insight to guide the technical aspect of EBD in CD 21 .…”
Section: Discussionmentioning
confidence: 99%