Imaging of isoproterenol-induced myocardial injury with  18 F labeled fluoroglucaric acid in a rat model

Houson, Hailey; Nkepang, Gregory; Hedrick, Andria; Awasthi, Vibhudutta

doi:10.1016/j.nucmedbio.2017.12.006

Cited by 15 publications

(22 citation statements)

References 31 publications

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“…The glucose conversion after 120-min reaction was 98.3%, with a yield of GNA plus GRA of 91.9%, and a Faradaic efficiency (FE) for GNA plus GRA production of 87% (entry 3, Table 1). We also studied the potential glucose decomposition in an alkaline aqueous solution on open circuit with 1 H, 13 C nuclear magnetic resonance (NMR) and 2D-HSQC NMR ( Supplementary Fig. 13).…”

Section: Articlementioning

confidence: 99%

“…Another note is that the formation of GNA and GRA could not be differentiated with the FTIR spectra only, as these two compounds have very similar functional group compositions. In addition to the IR spectra, the 1 H, 13 C and 2D HSQC NMR as well as LC-MS analyses were also performed. The 1 H and 13 C NMR spectra of the reactant and 6-h products from glucose electrolysis are presented in Supplementary Fig.…”

Section: Articlementioning

confidence: 99%

“…GRA is recognized as a "top value added compound" produced from biomass 9 , because it is a key intermediate for the production of biodegradable polymers, biodegradable detergents, and metal complexation agents 10,11 . Moreover, GRA and its derivatives (e.g., GRA-Ca, GRA-1,4-lactone) can also be used for healthcare purposes such as cancer chemotherapy and cholesterol reduction [12][13][14] . According to a market report by Grand View Research, Inc. 15 , the global GRA market size in 2016 was about USD 550.4 million and is expected to reach USD 1.30 billion by 2025.…”

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confidence: 99%

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Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

et al. 2020

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Glucose electrolysis offers a prospect of value-added glucaric acid synthesis and energysaving hydrogen production from the biomass-based platform molecules. Here we report that nanostructured NiFe oxide (NiFeO x ) and nitride (NiFeN x ) catalysts, synthesized from NiFe layered double hydroxide nanosheet arrays on three-dimensional Ni foams, demonstrate a high activity and selectivity towards anodic glucose oxidation. The electrolytic cell assembled with these two catalysts can deliver 100 mA cm −2 at 1.39 V. A faradaic efficiency of 87% and glucaric acid yield of 83% are obtained from the glucose electrolysis, which takes place via a guluronic acid pathway evidenced by in-situ infrared spectroscopy. A rigorous process model combined with a techno-economic analysis shows that the electrochemical reduction of glucose produces glucaric acid at a 54% lower cost than the current chemical approach. This work suggests that glucose electrolysis is an energy-saving and cost-effective approach for H 2 production and biomass valorization.

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Section: Articlementioning

confidence: 99%

Section: Articlementioning

confidence: 99%

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Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

et al. 2020

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“…The timeline of PET and SPECT imaging sessions are described in Figure 1. A few of the rats recruited in this study were also subjected to another PET imaging session using 18 F‐fluoroglucaric acid as has been reported in a separate article 27 …”

Section: Methodsmentioning

confidence: 99%

Drug‐induced cardiomyopathy: Characterization of a rat model by [¹⁸F]FDG/PET and [^99mTc]MIBI/SPECT

Houson

Hedrick

Awasthi

2020

Anim Models and Exp Med

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Background Drug‐induced cardiomyopathy is a significant medical problem. Clinical diagnosis of myocardial injury is based on initial electrocardiogram, levels of circulating biomarkers, and perfusion imaging with single photon emission computed tomography (SPECT). Positron emission tomography (PET) is an alternative imaging modality that provides better resolution and sensitivity than SPECT, improves diagnostic accuracy, and allows therapeutic monitoring. The objective of this study was to assess the detection of drug‐induced cardiomyopathy by PET using 2‐deoxy‐2‐[18F]fluoro‐D‐glucose (FDG) and compare it with the conventional SPECT technique with [99mTc]‐Sestamibi (MIBI). Methods Cardiomyopathy was induced in Sprague Dawley rats using high‐dose isoproterenol. Nuclear [18F]FDG/PET and [99mTc]MIBI/SPECT were performed before and after isoproterenol administration. [18F]FDG (0.1 mCi, 200‐400 µL) and [99mTc]MIBI (2 mCi, 200‐600 µL) were administered via the tail vein and imaging was performed 1 hour postinjection. Isoproterenol‐induced injury was confirmed by the plasma level of cardiac troponin and triphenyltetrazolium chloride (TTC) staining. Results Isoproterenol administration resulted in an increase in circulating cardiac troponin I and showed histologic damage in the myocardium. Visually, preisoproterenol and postisoproterenol images showed alterations in cardiac accumulation of [18F]FDG, but not of [99mTc]MIBI. Image analysis revealed that myocardial uptake of [18F]FDG reduced by 60% after isoproterenol treatment, whereas that of [99mTc]MIBI decreased by 45%. Conclusion We conclude that [18F]FDG is a more sensitive radiotracer than [99mTc]MIBI for imaging of drug‐induced cardiomyopathy. We theorize that isoproterenol‐induced cardiomyopathy impacts cellular metabolism more than perfusion, which results in more substantial changes in [18F]FDG uptake than in [99mTc]MIBI accumulation in cardiac tissue.

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“…PET Imaging with 18 F-labeled fluorodeoxyglucaric acid ( 18 F-FGA): For PET imaging, 18 F-FGA was synthesized from commercially available 18 F-fluorodeoxyglucose ( 18 F-FDG). The methods of synthesis and quality control are described in previous reports 25,26 . Anesthetized rats received approximately 1 mCi of 18 F-FGA intravenously via the tail vein.…”

Section: Neurological Function Assessmentmentioning

confidence: 99%

Modeling traumatic brain injury combined with hemorrhagic shock in rats: Neurological assessment and PET imaging with ¹⁸F-fluorodeoxyglucaric acid

Hedrick

Mdzinarishvili

et al. 2021

Preprint

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Traumatic brain injury (TBI)is a major cause of death and disability worldwide. Hemorrhagic shock (HS) aggravates tissue injury and complicates TBI recovery. We studied the combined insult of mild TBI and HS and investigated the impact of varying loss of blood volume on neurologic deficit and brain lesion volume. A novel positron emission tomography (PET) technique was employed to monitor tissue injury. Male Sprague Dawley rats received mTBI by controlled cortical impact (CCI) followed by withdrawal of 0%, 30-40%, 45%, or 50% of blood (mTBI, mTBI+HS≤40%, mTBI+HS45%, and mTBI+HS50%, respectively). Neurological deficit (mNSS= 5.6, 7.6, and 12.3) and mortality (2/12, 2/6, and 7/12) were higher in mTBI+HS≤40%, mTBI+HS45%, and mTBI+HS50%, than in mTBI alone rats (no death; mNSS=3.3). Histologic lesion size increased 3.5-fold in mTBI+HS50% compared to mTBI alone and the infarct-avid PET agent 18F-fluorodeoxyglucaric acid (FGA) proportionately detected tissue necrosis in mTBI+HS50% rats. Based on these results, we conclude that HS aggravates mTBI-induced neurological deficits, tissue injury and mortality. PET using 18F-FGA as an imaging marker can detect the extent of injury in a non-invasive manner.

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Imaging of isoproterenol-induced myocardial injury with 18 F labeled fluoroglucaric acid in a rat model

Cited by 15 publications

References 31 publications

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

Drug‐induced cardiomyopathy: Characterization of a rat model by [¹⁸F]FDG/PET and [^99mTc]MIBI/SPECT

Modeling traumatic brain injury combined with hemorrhagic shock in rats: Neurological assessment and PET imaging with ¹⁸F-fluorodeoxyglucaric acid

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Imaging of isoproterenol-induced myocardial injury with 18 F labeled fluoroglucaric acid in a rat model

Cited by 15 publications

References 31 publications

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

Efficient electrochemical production of glucaric acid and H2 via glucose electrolysis

Drug‐induced cardiomyopathy: Characterization of a rat model by [18F]FDG/PET and [99mTc]MIBI/SPECT

Modeling traumatic brain injury combined with hemorrhagic shock in rats: Neurological assessment and PET imaging with 18F-fluorodeoxyglucaric acid

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Drug‐induced cardiomyopathy: Characterization of a rat model by [¹⁸F]FDG/PET and [^99mTc]MIBI/SPECT

Modeling traumatic brain injury combined with hemorrhagic shock in rats: Neurological assessment and PET imaging with ¹⁸F-fluorodeoxyglucaric acid