Imaging of Liposarcoma: Classification, Patterns of Tumor Recurrence, and Response to Treatment

O’Regan, Kevin; Jagannathan, Jyothi P.; Krajewski, Katherine M.; Zukotynski, Katherine; Souza, Frederico; Wagner, Andrew J.; Ramaiya, Nikhil H.

doi:10.2214/ajr.10.5824

Cited by 65 publications

(70 citation statements)

References 11 publications

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“…[24][25][26][27] The imaging findings frequently overlap, including typical imaging features such as the triple sign, which may also be seen in undifferentiated pleomorphic sarcoma. 5 SS may rarely appear almost cystic on pre-contrast MRI (as seen in one of our patients) and may then mimic other cystic lesions such as a poplitaeal cyst (if around the knee joint) or a haematoma, and heterogeneous contrast enhancement helps differentiate between the two in these cases.…”

Section: -23mentioning

confidence: 99%

Imaging features of primary and metastatic extremity synovial sarcoma: a single institute experience of 78 patients

Baheti

Tirumani²,

Sewatkar³

et al. 2015

BJR

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Objective: To study the appearance of primary and metastatic extremity synovial sarcoma (SS) on crosssectional imaging. Methods: In this institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study, the imaging features of 78 patients (42 males and 36 females; mean age, 40 years) with primary and metastatic extremity SS on MRI and multidetector CT were reviewed, with baseline MRI of the primary available in 31 patients. Results: Primary SSs were predominantly wellcircumscribed (27/31) and heterogeneously enhancing solid (18/31) or solid-cystic (13/31) tumours. Imaging features visualized included the presence of perilesional oedema (14/31), interfascial (15/31) and intercompartmental extension (7/31), triple sign (11/31), intratumoral haemorrhage (10/31), calcification (6/31), bowl of grapes appearance (5/31) and bone involvement (3/31). Smaller T1 stage tumours (8/31) appeared as heterogeneously enhancing lesions, with some lesions demonstrating interfascial and intercompartmental extension and perilesional oedema. Recurrent/metastatic disease developed in 49/78 (63%) patients. Of these, 20/78 (26%) had metastasis at presentation, while the remaining developed metastatic disease at a median interval of 27 months (range, 3-161 months). Pleuropulmonary metastases (46/78) were the most common sites, with most of the metastases being pleural based. On univariate analysis, larger tumour size, the presence of perilesional oedema, intercompartmental extension, the presence of intralesional haemorrhage and bowl of grapes appearance on MRI were associated with a significantly higher incidence of metastatic disease. Conclusion: Certain imaging features of primary SS predict the risk of development of metastatic disease. Imaging features of T1 stage tumours included heterogeneous enhancement, interfascial extension and perilesional oedema. Pleural-based metastases are commonly seen in SSs. Advances in knowledge: Imaging features of primary SS correlate with metastatic disease. Pleural-based metastases are often present in SSs.Synovial sarcoma (SS) is a relatively common high-grade sarcoma, accounting for 5-10% of soft-tissue sarcomas.

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Section: -23mentioning

confidence: 99%

Imaging features of primary and metastatic extremity synovial sarcoma: a single institute experience of 78 patients

Baheti

Tirumani²,

Sewatkar³

et al. 2015

BJR

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“…1.katergoride atipik lipomatöz tümör, iyi diferansiye liposarkom ve dediferansiye liposarkom yer alır. İkinci kategoride miksoid liposarkom ve yuvarlak hücreli liposarkom, 3.kategoride pleomorfik liposarkom yer alır [34].…”

Section: Li̇posarkomunclassified

“…Bu tümörlerin yağ doku komponenti tümör volümünün %75 veya daha fazlasıdır. İyi sınırlı olan tümörün içinde kalın ve düzensiz septalar mevcuttur ve bu septalar T1-A görüntülerde hipointens, yağ baskılamalı T2-A görüntülerde hiperintenstir ve kontrast madde ile parlaklaş-ma gösterir ayrıca tümör içinde küçük nodüler yumuşak doku alanları bulunabilir [34,35].…”

Section: Li̇posarkomunclassified

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Alt Ekstremite Tumorleri

Arkun¹

2017

Trd Sem

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“…Vulvar LPS is difficult to be accurately diagnosed preoperatively and may be misinterpreted as benign lesions due to their close resemblance to Bartholin's gland pathologies such as cysts or abscesses, inguinal or femoral hernias, or benign softtissue tumors as a result of their location and appearance. Imaging modalities such as ultrasonography (US), color Doppler ultrasonography (CDUS), computed tomography (CT) and magnetic resonance imaging (MRI) have been used to assess soft tissue tumors [3,4]. Especially US is the first line examination technique in vulvar pathologies.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonography findings of vulvar liposarcoma. Case report.

et al. 2015

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Liposarcoma (LPS) of vulva is a rare entity. We present the ultrasonographic (US) and color Doppler ultrasonographic (CDUS) findings of a vulvar myxoid LPS. Although LPS cases have been reported in the extremities and trunk, the US or CDUS findings of LPS in vulva have not been described previously. On US the mass appeared as a well-defined, homogeneous hypoechoic structure and on CDUS it was quite hypervascular.

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Imaging of Liposarcoma: Classification, Patterns of Tumor Recurrence, and Response to Treatment

Abstract: The subtypes of LPS with greater nonlipomatous soft-tissue components on imaging studies tend to show less differentiation and are usually more aggressive both histologically and clinically. Imaging plays an important role in the diagnosis, surveillance, and response assessment of LPS.

Cited by 65 publications

References 11 publications

Imaging features of primary and metastatic extremity synovial sarcoma: a single institute experience of 78 patients

Imaging features of primary and metastatic extremity synovial sarcoma: a single institute experience of 78 patients

Alt Ekstremite Tumorleri

Ultrasonography findings of vulvar liposarcoma. Case report.

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