Imaging of Metastatic Orbital Leiomyosarcoma

Voros, Gerasimos M.; Birchall, Daniel; Ressiniotis, Thomas; Neoh, C; Owen, Rona I.; Strong, Nicholas

doi:10.1097/01.iop.0000185085.49647.5f

Cited by 11 publications

(11 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The primary tumors originated in the uterus, gastrointestinal tract, vein, spermatic cord, hip, retroperitoneum, or soft tissue of the thigh. [3][4][5][6][7][8][9][10] Orbital leiomyosarcoma has no specific clinical symptoms. Because of the relatively fast growth of leiomyosarcoma, patients may experience progressive exophthalmos during the early stages of the disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case of Orbital Metastasis of Uterine Leiomyosarcoma With Intracranial Extension Presenting With Proptosis

Kim

Park

Min

et al. 2016

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

A 57-year-old woman presented with protrusion of the OS 2 months in duration and decreased vision 1 month in duration. The patient was diagnosed with uterine leiomyosarcoma approximately 3 years before presentation. Lung and liver metastases were diagnosed by biopsy 1 year prior to this visit. CT revealed a solid mass with central necrosis in the left lateral orbit that resulted in orbital shifting, bony destruction, and intracranial extension. The diagnosis was left orbital metastatic leiomyosarcoma, and the patient died 2 months after receiving the diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10] In addition, very few cases of metastatic orbital leiomyosarcoma have been reported in the medical literature. To the authors' knowledge, only one case of orbital leiomyosarcoma with intracranial extension has been described previously.…”

mentioning

confidence: 99%

A Case of Orbital Metastasis of Uterine Leiomyosarcoma With Intracranial Extension Presenting With Proptosis

Kim

Park

Min

et al. 2016

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

show abstract

“…In four cases, the leiomyosarcomas spread to the orbit from nearby tissues, such as the sinuses [12]. Leiomyosarcomas metastasized to the orbit from various locations in nine cases, including the spermatic cord, soft tissue of the thigh, rectum, uterus, hip, gastrointestinal tract, abdomen, and vein [13][14][15][16][17]. Primary orbital leiomyosarcomas are thought to develop from vascular or sympathetic smooth muscle [2].…”

Section: Discussionmentioning

confidence: 99%

Orbital metastasis of retroperitoneal leiomyosarcoma

Chen

Wei

2011

Med Oncol

View full text Add to dashboard Cite

Leiomyosarcoma is a relatively rare form of cancer most commonly found in the uterus, stomach, small intestine, retroperitoneum, and vascular tissue. Metastasis is common and surgery with a wide margin of resection is generally considered the most effective management. Leiomyosarcomas, metastatic or primary, of the orbit have rarely been reported. Herein, we report the case of a 51-year-old female with metastatic orbital leiomyosarcoma. The diagnosis was based on her history of leipmyosarcoma, orbital ultrasonography, and computed tomography and confirmed by postoperative histochemistry. She was treated with surgical excision and has remained without recurrence 1 year after surgery.

show abstract

“…Primary orbital leiomyosarcomas are isointense to extraocular muscle tissue and cerebral gray matter on MRI T1-weighted sequences, with notable peripheral rim enhancement. 5 However, Voros et al 6 noted that metastatic orbital leiomyosarcomas may demonstrate more diffuse enhancement. Our case presented with a lesion that radiographically appeared intrinsic to the extraocular muscle with both diffuse enhancement of the lesion but also with recognizable rim enhancement.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9] They are relatively insensitive to chemotherapy and radiation; wide surgical excision is often recommended. Some advocate exenteration, given the aggressive nature of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor

et al. 2017

View full text Add to dashboard Cite

SummaryLeiomyosarcomas, neoplasms of smooth muscle, are rarely found within the orbit. Orbital leiomyosarcoma may be primary, metastatic, or secondary to radiation. When they are metastatic, patients almost exclusively have a history of a primary leiomyosarcoma, often occurring in the spermatic cord, skin, gastrointestinal tract, or the uterus. We present the case of 48-year-old woman who presented with a metastatic orbital leiomyosarcoma, which was identified before the primary tumor. Case ReportA 48-year-old woman with a history of primary openangle glaucoma presented at Massachusetts Eye and Ear with binocular, horizontal diplopia, intermittent left retrobulbar pain, and mild discomfort of the left eye with eye movement. The patient complained of a 4-month history of hypoesthesia of the left cheek, which she associated to apparent nerve injury from ipsilateral injection of a local anesthetic for a root canal performed just prior to onset of symptoms. The patient's visual acuity was 20/15 in each eye, with slight dyschromatopsia in both eyes. She had a superior arcuate visual field defect in the left eye secondary to glaucoma ( Figure 1A). There was 1 mm of proptosis and limitation of abduction of the left eye resulting in an incomitant esotropia larger in left gaze. Magnetic resonance imaging (MRI) demonstrated a well circumscribed lesion in the left orbital apex that appeared inseparable from the left lateral rectus muscle; the lesion enhanced slightly less than muscle, with more prominent enhancement of the rim of the lesion (Figure 2).Given that the lesion appeared intrinsic to the extraocular muscle, a common site to harbor an orbital metastasis, the patient underwent a systemic work-up searching for an occult primary malignancy. An 18-fluorodeoxyglucose positron emission tomography (18-FDG PET) scan showed a right lower quadrant mass that was lobulated and heterogeneously enhancing with 18-FDG avidity in the pelvis demonstrating its hypermetabolic nature (Figure 3).A radiologically guided core needle biopsy was performed of the mass. The pathology demonstrated eosinophilic spindle-shaped cells with elongated nuclei, scattered mitotic figures, and areas of ischemic degeneration. The lesion stained positive for both desmin and smooth muscle actin, in keeping with a malignant smooth muscle neoplasm, specifically a leiomyosarcoma (Figure 4). Systemic chemotherapy was being considered for management of her metastatic disease when the patient developed worsening retrobulbar pain (2 months after initial presentation). On examination, her visual acuity was reduced to 20/25, and there was notable worsening of the dyschromatopsia and visual field defect in the left eye ( Figure 1B). In addition, she had further limitation of abduction of the left eye. Repeat MRI scan demonstrated enlargement of the lesion, with compression of the left optic nerve laterally ( Figure 5). In order

show abstract

Imaging of Metastatic Orbital Leiomyosarcoma

Cited by 11 publications

References 5 publications

A Case of Orbital Metastasis of Uterine Leiomyosarcoma With Intracranial Extension Presenting With Proptosis

A Case of Orbital Metastasis of Uterine Leiomyosarcoma With Intracranial Extension Presenting With Proptosis

Orbital metastasis of retroperitoneal leiomyosarcoma

Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor

Contact Info

Product

Resources

About