Imaging of Multiple Myeloma: Usefulness of MRI and PET/CT

Koppula, Bhasker R.; Kaptuch, Justin M.; Hanrahan, Christopher J.

doi:10.1053/j.sult.2013.05.006

Cited by 15 publications

(11 citation statements)

References 70 publications

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“…In this system, the extent of bone lesions is determined by radiographic bone survey. 6,24 Bone disease is the hallmark of MM, occurring in approximately two thirds of patients at diagnosis and in up to 90% of patients during the course of disease. Despite the substantial advances in MM therapy over the last decades, bone disease remains a major cause of morbidity and mortality in MM patients.…”

Section: Discussionmentioning

confidence: 99%

“…The measurement of β2-microglobulin and serum albumin levels is the basis of the ISS, which is created to standardize the classification of myeloma using more widely available measures of disease. 3,24 However, cutoff levels for these variables are controversial because in advanced disease, the increase in β2-microglobulin levels could be due to both tumor burden or renal failure. Moreover, a recent study suggested that ISS is strongly dependent from age-related comorbidity burden lacking specificity for MM.…”

Section: Discussionmentioning

confidence: 99%

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18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma

Fonti¹,

Pace²,

Cerchione³

et al. 2015

Clinical Nuclear Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma

Fonti¹,

Pace²,

Cerchione³

et al. 2015

Clinical Nuclear Medicine

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show abstract

“…Although new or enlarging lesions generally mean disease progression, lytic bone lesions rarely show evidence of healing on plain radiographs, and routine follow-up skeletal survey is of no benefit [44].…”

Section: Multiple Myelomamentioning

confidence: 99%

“…MR in patients with clinical and laboratory findings of symptomatic myeloma provides prognostic information and may detect unsuspected myeloma lesions [44]. Five different infiltration patterns can be differentiated on MR: normal appearance of bone marrow despite minor microscopic plasma cell infiltration, focal involvement, homogeneous diffuse infiltration, combined diffuse and focal infiltration, and “salt-and-pepper” pattern with inhomogeneous bone marrow with interposition of fat islands [47].…”

Section: Multiple Myelomamentioning

confidence: 99%

Imaging of Malignant Primitive Tumors of the Spine

Mechri¹,

Riahi²,

Sboui³

et al. 2018

Journal of the Belgian Society of Radiology

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Primary malignant tumors of the spine are rare and mainly include chordoma, chondrosarcoma, Ewing sarcoma or primitive neuroectodermal tumor, and osteosarcoma. The final diagnosis is based on the combination of patient age, topographic and histologic features of the tumor, and lesion pattern on computed tomography (CT) and magnetic resonance (MR) imaging. Imaging evaluation includes radiography, CT, bone scintigraphy, and MR imaging. CT is more useful than radiography for evaluating location of the lesion and analyzing bone destruction and matrix, whereas MR has unmatched ability to assess soft tissue extension. This pictorial review provides an overview of the most prevalent primitive malignant tumors of spine.

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“…As mentioned earlier, use of MR imaging and PET/CT for diagnosis, staging, and management of patients with multiple myeloma continues to increase. PET/CT provides reliable information to help detect early bone involvement, identify extramedullary disease, and predict prognosis (32)(33)(34). FDG PET can help identify areas of metabolic activity that represent clonal plasma cell proliferation, which complements and frequently precedes evidence of osseous destruction at radiography or CT.…”

Section: Use Of Mr Imaging and Pet/ct In Staging And Diagnosismentioning

confidence: 99%

MR Imaging and PET/CT in Diagnosis and Management of Multiple Myeloma

et al. 2015

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Multiple myeloma is a common hematologic malignancy among the elderly population. Although there have been many advances in treatment over the past few decades, the overall prognosis for the disease remains poor. Conventional radiography has long been the standard of reference for the imaging of multiple myeloma. However, 10%-20% of patients with multiple myeloma do not have evidence of disease at conventional radiography. There is a growing body of evidence supporting use of magnetic resonance (MR) imaging and 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) in diagnosis and management of multiple myeloma. MR imaging is useful in detection of bone marrow infiltration, a finding often missed at conventional radiography. FDG PET/CT is especially sensitive for the detection of extramedullary disease and can help detect the metabolically active lesions that often precede evidence of osseous destruction at conventional radiography. MR imaging and FDG PET/CT are useful tools that can provide essential information for diagnosis and management of patients with multiple myeloma. Both modalities allow accurate localization of disease after chemotherapy or autologous stem cell transplantation and can provide important prognostic information that can influence further clinical decision making regarding therapy, particularly when tumor serum markers may be a less reliable indicator of disease burden after repeated treatments.

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Imaging of Multiple Myeloma: Usefulness of MRI and PET/CT

Cited by 15 publications

References 70 publications

18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma

18F-FDG PET/CT, 99mTc-MIBI, and MRI in the Prediction of Outcome of Patients With Multiple Myeloma

Imaging of Malignant Primitive Tumors of the Spine

MR Imaging and PET/CT in Diagnosis and Management of Multiple Myeloma

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