2016
DOI: 10.1161/circimaging.116.004713
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Imaging of Post-Infarct Inflammation

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Cited by 7 publications
(5 citation statements)
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“…Hence, given these drawbacks of 18 F-FDG, other more leukocyte-specific tracers (e.g. 68 Ga-Pentixafor or 18 F-GE180), might be subject of future studies for investigating the inflammatory cascade in myocarditis 7 . Moreover, the small sample size in the CD34/CD44 assessment of the present study limits its statistical power.…”
Section: Discussionmentioning
confidence: 89%
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“…Hence, given these drawbacks of 18 F-FDG, other more leukocyte-specific tracers (e.g. 68 Ga-Pentixafor or 18 F-GE180), might be subject of future studies for investigating the inflammatory cascade in myocarditis 7 . Moreover, the small sample size in the CD34/CD44 assessment of the present study limits its statistical power.…”
Section: Discussionmentioning
confidence: 89%
“…However, functional imaging modalities offer several key advantages in non-invasive inflammatory imaging, e.g. direct interrogation of infiltrating immune cells on a subcellular level 7 . Consequently, the combination of PET and MRI could provide incremental information about myocardial injury and inflammatory activity: in a small cohort of ten patients, simultaneous PET/MRI using 18 F-FDG was feasible to diagnose both cardiac sarcoidosis and myocarditis 36 .…”
Section: Discussionmentioning
confidence: 99%
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“…While FDG PET imaging targets activated macrophages, it is still a non-specific probe that can accumulate in other metabolically active tissues which can therefore introduce interfering background signal. 36 , 37 Imaging of the ascending aorta requires strict dietary preparation to suppress FDG-myocardium uptake (with a high-fat, low-carbohydrate diet prior to PET imaging), given the significant background myocardial FDG uptake which can make it more difficult to differentiate vascular inflammation from background uptake. 38 , 39 FDG PET imaging is also affected by glucose levels, so particular caution in imaging patients with diabetes and hyperglycemia must be employed.…”
Section: Discussionmentioning
confidence: 99%