Imaging of primary central nervous system lymphoma

Tang, Yueting; Booth, T.C.; Bhogal, Pervinder; Malhotra, Ajay; Wilhelm, Thomas

doi:10.1016/j.crad.2011.03.006

Cited by 92 publications

(72 citation statements)

References 49 publications

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“…It is also possible that PCNSL is composed of numerous macrophages that also contribute to the lipid signal. 27 The increase of lactate results from anaerobic metabolism, which is thought to be related to several mechanisms such as necrosis, demyelination, the inflammatory process, or mitochondrial dysfunction. 14,25,28 In our study, the only patient with TDL with a high lactate peak had necrosis.…”

Section: Discussionmentioning

confidence: 99%

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Kim

et al. 2013

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Kim

et al. 2013

American Journal of Neuroradiology

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“…This appears to be due to numerous macrophages and the increased turnover of membrane components in transformed lymphoid cells which contain high concentrations of mobile lipids [112].…”

Section: Primary Central Nervous System Lymphomas (Pcnsl)mentioning

confidence: 99%

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Kousi¹,

Tsougos²,

Eftychia³

2013

Novel Frontiers of Advanced Neuroimaging

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“…Differentiating the above mentioned malignant tumors can be a challenge on routine MR imaging because of overlapping imaging findings (1). It is critical to distinguish CNS lymphomas from other enhancing malignant lesions preoperatively due to distinct prognostic implications and differing surgical planning and treatment options.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of enhancement-perfusion mismatch in differentiation of CNS lymphomas from other enhancing malignant tumors of the brain

Goyal¹,

Kumar²,

Gupta³

et al. 2017

Quant. Imaging Med. Surg.

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Background: Surgical planning and treatment options for primary or secondary central nervous system lymphomas (PCNSL or SCNSL) are different from other enhancing malignant lesions such as glioblastoma multiforme (GBM), anaplastic gliomas and metastases; so, it is critical to distinguish them preoperatively.We hypothesized that enhancement-perfusion (E-P) mismatch on dynamic susceptibility weighted magnetic resonance (DSC-MR) perfusion imaging which corresponds to low mean relative cerebral blood volume (mean rCBV) in an enhancing portion of the tumor should allow differentiation of CNS lymphomas from other enhancing malignant lesions. Methods:We retrospectively reviewed pre-treatment MRI exams, including DSC-MR perfusion images of 15 lymphoma patients. As a control group, pre-treatment DSC-MR perfusion images of biopsy proven 18 GBMs (group II), 13 metastases (group III), and 10 anaplastic enhancing gliomas (group IV) patients were also reviewed.Region of interests (ROIs) were placed around the most enhancing part of tumor on contrast-enhanced T1WI axial images and images were transferred onto co-registered DSC perfusion maps to obtain CBV in all 4 groups.The mean and maximum relative CBV values were obtained. Statistical analysis was performed on SPSS software and significance of the results between the groups was done with Mann-Whitney test, whereas optimal thresholds for tumor differentiation were done by receiver operating characteristic (ROC) analysis.Results: The enhancing component of CNS lymphomas were found to have significantly lower mean rCBV compared to enhancing component of GBM (1.2 versus 4.3; P<0.001), metastasis (1.2 versus 2.7; P<0.001), and anaplastic enhancing gliomas (1.2 versus 2.4; P<0.001). Maximum rCBV of enhancing component of lymphoma were significantly lower than GBM (3.1 versus 6.5; P<0.001) and metastasis (3.1 versus 4.9; P<0.013), and not significantly lower than anaplastic enhancing gliomas (3.9 versus 4.2; P<0.08).On the basis of ROC analysis, mean rCBV provided the best threshold [area under the curve (AUC) =0.92] and had better accuracy in differentiating malignant lesions.Conclusions: E-P mismatch in DSC perfusion MR, i.e., low mean rCBV in an enhancing portion of the tumor is strongly suggestive of lymphoma and should allow differentiation of CNS lymphoma from other enhancing malignant lesions.

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Imaging of primary central nervous system lymphoma

Cited by 92 publications

References 49 publications

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Usefulness of enhancement-perfusion mismatch in differentiation of CNS lymphomas from other enhancing malignant tumors of the brain

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