Abstract:Surveillance imaging is likely unnecessary in patients with a known diagnosis of pediatric lymphoma of bone. Pretreatment and post-treatment PET/CT is likely sufficient to assess response. There is little data to support the use of interim and surveillance PET/CT.
“…In a recent study dealing with primary pediatric lymphoma of the bone, post-treatment follow-up with conventional morphologic imaging (without DWI) did not alter clinical management in the absence of symptoms, in particular also due to the lack of correlation between osseous changes after treatment on conventional morphologic images and clinical outcome [59]. Only FDG PET CT proved capable of demonstrating metabolic imaging changes consistent with the clinical response to treatment [59]. The diagnosis of PIL is, therefore, most often complemented by FDG PET CT or more recently by FDG PET MRI.Fig.…”
Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of these lesions. Although rare, pediatric tumors arising in the facial bones comprise a wide spectrum of benign and malignant lesions of osteogenic, fibrogenic, hematopoietic, neurogenic, or epithelial origin. The more common lesions include Langerhans cell histiocytosis and osteoma, while rare lesions include inflammatory myofibroblastic and desmoid tumors; juvenile ossifying fibroma; primary intraosseous lymphoma; Ewing sarcoma; and metastases to the facial bones from neuroblastoma, Ewing sarcoma, or retinoblastoma. This article provides a comprehensive approach for the evaluation of children with non-odontogenic tumors of the facial skeleton. Typical findings are discussed with emphasis on the added value of multimodality multiparametric imaging with computed tomography (CT), magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), positron emission tomography CT (PET CT), and PET MRI. Key imaging findings and characteristic histologic features of benign and malignant lesions are reviewed and the respective role of each modality for pretherapeutic assessment and post-treatment follow-up. Pitfalls of image interpretation are addressed and how to avoid them.
“…In a recent study dealing with primary pediatric lymphoma of the bone, post-treatment follow-up with conventional morphologic imaging (without DWI) did not alter clinical management in the absence of symptoms, in particular also due to the lack of correlation between osseous changes after treatment on conventional morphologic images and clinical outcome [59]. Only FDG PET CT proved capable of demonstrating metabolic imaging changes consistent with the clinical response to treatment [59]. The diagnosis of PIL is, therefore, most often complemented by FDG PET CT or more recently by FDG PET MRI.Fig.…”
Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of these lesions. Although rare, pediatric tumors arising in the facial bones comprise a wide spectrum of benign and malignant lesions of osteogenic, fibrogenic, hematopoietic, neurogenic, or epithelial origin. The more common lesions include Langerhans cell histiocytosis and osteoma, while rare lesions include inflammatory myofibroblastic and desmoid tumors; juvenile ossifying fibroma; primary intraosseous lymphoma; Ewing sarcoma; and metastases to the facial bones from neuroblastoma, Ewing sarcoma, or retinoblastoma. This article provides a comprehensive approach for the evaluation of children with non-odontogenic tumors of the facial skeleton. Typical findings are discussed with emphasis on the added value of multimodality multiparametric imaging with computed tomography (CT), magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), positron emission tomography CT (PET CT), and PET MRI. Key imaging findings and characteristic histologic features of benign and malignant lesions are reviewed and the respective role of each modality for pretherapeutic assessment and post-treatment follow-up. Pitfalls of image interpretation are addressed and how to avoid them.
“…Клиническая онкогематология. 2020;13(1): 33-49. DOI: 10.21320/2500-2139-2020-13-1- [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] were subjected to biopsy. None of 4 cases was reported to show tumors.…”
Section: клиническая онкогематологияmentioning
confidence: 99%
“…Некоторые исследователи полагают, что нарастание склеротических изменений при исходном литическом типе деструкции служит косвенным подтверждением регрессии опухоли. Однако этот признак не является универсальным, т. к. остаточные изменения при ПЛК далеко не всегда представлены остеосклерозом [30,[37][38][39][40]. Проведение повторной биопсии остаточного образования нередко сопряжено с серьезными техническими сложностями, а также может увеличить риск патологических переломов при локализации в длинных трубчатых костях [30,31,41].…”
Актуальность. Первичная лимфома костей (ПЛК)это редкая злокачественная опухоль. Первичное обследование, предполагающее выявление всех исходных очагов поражения, служит необходимым условием выбора наиболее оптимальной тактики противоопухолевого лечения. Использование стандартных методов диагностики (рентгенография, КТ, МРТ) не всегда позволяет оценить истинную распространенность опухоли. Другой хорошо известной особенностью ПЛК является сложность при оценке эффекта проводимого лечения в связи с выраженными остаточными изменениями в костях, которые сохраняются у большинства пациентов. К тому же данные о применении при ПЛК такого метода метаболической визуализации, как 18 F-FDG ПЭТ, в доступной литературе встречаются нечасто. Цель. Изучить особенности использования ПЭТ-КТ с 18 F-FDG при первичном обследовании и оценке эффективности терапии у пациентов с ПЛК. Материалы и методы. В исследование включен 21 больной ПЛК, которому при первичном обследовании и через 1 мес. после окончания терапии выполнена 18 F-FDG ПЭТ. Результаты 18 F-FDG ПЭТ сопоставлялись с данными структурных методов диагностики (КТ, МРТ) и исследованием материала биопсии патологических очагов. Результаты. Интенсивный захват 18 F-FDG (SUV max 8,6-40,1, среднее SUV max 23,5), по данным ПЭТ, отмечался у всех пациентов в очагах опухоли, выявленных по результатам структурных методов диагностики и подтвержденных биопсией. Кроме того, в каждом из 21 наблюдения определялась патологическая инфильтрация прилежащих мягких тканей с высокой метаболической LYMPHOID TUMORS
“…The most frequent subtype of PBL is the Diffuse Large B-Cell Lymphoma, responsible for about 50% of the cases. 3 Among the other possible etiologies for PBL, about 37% are classified as Lymphoblastic Lymphomas, while only 13% of the cases are due to other subtypes, revealing the rarity of BL with bone involvement. 3 …”
Section: Introductionmentioning
confidence: 99%
“… 3 Among the other possible etiologies for PBL, about 37% are classified as Lymphoblastic Lymphomas, while only 13% of the cases are due to other subtypes, revealing the rarity of BL with bone involvement. 3 …”
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