Abstract3D, 4D and predictive geological modelling, including all known geoscientific data, were applied to the 100 × 25 km large Neves Corvo project area located in the Portuguese part of the Iberian Pyrite Belt. The lowermost unit in the area is the Givetian to Famennian-Strunian PhylliteQuartzite Group (PQG), which is overlain by three SE-plunging volcanic axes with the Strunian to Visean Volcanic Sedimentary Complex (VSC), hosting in its lower sequence the Neves Corvo VHMS giant deposit. The VSC is covered with mid late Visean and Serpukhovian to Bashkirian flysch rocks [Mértola and Mira formations of the Baixo Alentejo Flysch Group (BAFG), respectively]. Six NE-SW deep 2D reflection seismic profiles acquired by LNEG between Neves Corvo mine and the Spanish border (60 km to the SE) during the ProMine project, allowed to extend a 3D-model of the Neves Corvo main thrust (that brings VSC rocks onto Mértola Fm. very close to VHMS ores) throughout the eastern part of the area. NE-SW to ENE-WSW (sinistral) and N-S to NNW-SSE (dextral) late Variscan strike-slip oblique faults (a few >5 km deep) displaced all former geological units and structures, as shown by the 3D models. In late Variscan time, small vein-type Cu (and other metals) deposits were emplaced along them.