Imaging of renal tumours in infancy and childhood

Riccabona, Michael

doi:10.1007/s00330-003-2001-x

Cited by 60 publications

(39 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The left size was most affected (p < 0.05). The patients' age at the moment of the CT scan was slightly higher than reported in the literature for the diagnosis of WT (7,9) . Considering that some patients underwent CT scan after chemotherapy, probably such a difference is not real, since some CT scans were performed few weeks after the diagnosis.…”

Section: Discussionmentioning

confidence: 57%

“…Initially, such methods were utilized to confirm the presence of a mass, suggesting a specific diagnosis, but later they started playing a role in the therapy and surgical plannings, besides the evaluation of the treatment response (2,(5)(6)(7)(8) . Certain imaging findings such as presence of metastases or vascular invasion have contributed to the therapeutic planning.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Local behavior and lymph node metastases of Wilms' tumor: accuracy of computed tomography

Silva

2014

Radiol Bras

View full text Add to dashboard Cite

ResumoObjective: To evaluate the accuracy of computed tomography for local and lymph node staging of Wilms' tumor. Materials and Methods: Each case of Wilms' tumor was evaluated for the presence of abdominal lymph nodes by a radiologist. Signs of capsule and adjacent organ invasion were analyzed. Surgical and histopathological results were taken as the gold standard. Results: Sensitivity was 100% for both mesenteric and retroperitoneal lymph nodes detection, and specificity was, respectively, 12% and 33%, with positive predictive value of 8% and 11% and negative predictive value of 100%. Signs of capsular invasion presented sensitivity of 87%, specificity of 77%, positive predictive value of 63% and negative predictive value of 93%. Signs of adjacent organ invasion presented sensitivity of 100%, specificity of 78%, positive predictive value of 37% and negative predictive value of 100%. Conclusion: Computed tomography tumor showed low specificity and low positive predictive value in the detection of lymph node dissemination. The absence of detectable lymph nodes makes their presence unlikely, and likewise regarding the evaluation of local behavior of tumors.Keywords: Computed tomography; Wilms' tumor; Staging.Objetivo: Avaliar a acurácia da tomografia computadorizada no estadiamento local e linfonodal de pacientes com tumor de Wilms. Materiais e Métodos: Um radiologista avaliou a presença de linfonodos abdominais em cada caso. Sinais de invasão capsular e de órgão adjacente foram analisados. Resultados cirúrgicos e histopatológicos foram tomados como padrão ouro. Resultados: A sensibilidade da detecção de linfonodos mesentéricos e retroperitoneais foi 100% (ambos) e a especificidade foi 12% e 33%, respectivamente, com valores preditivos positivos de 8% e 11% e negativos de 100% (ambos). Sinais de invasão capsular apresentaram sensibilidade de 87%, especificidade de 77% e valores preditivos positivo de 63% e negativo de 93%. Invasão de órgão adjacente foi diagnosticada com sensibilidade de 100%, especificidade de 78% e valores preditivos positivo de 37% e negativo de 100%. Conclusão: A tomografia computadorizada mostrou baixa especificidade e valor preditivo positivo na detecção de disseminação linfonodal. Ausência de linfonodos detectáveis tornou a disseminação improvável, assim como sinais de invasão local.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Local behavior and lymph node metastases of Wilms' tumor: accuracy of computed tomography

Silva

2014

Radiol Bras

View full text Add to dashboard Cite

show abstract

“…Using fast heavily T2-weighted (3D) sequences with breathhold or diaphragmatic triggering, the (dilated) pelvocalyceal system and ureter can be exquisitely demonstrated; note that previous hydration as well as the administration of furosemide is essential for an optimal fi lling (Sigmund et al 1991 ;Nolte-Ernsting et al 2001, 2003Borthne et al 2000Borthne et al , 2003Grattan-Smith and Jones 2006 ). Additionally, gadolinium (Gd) can be administered intravenously which then allows the assessment of renal and vascular anatomy, renal parenchymal contrast uptake, as well as excretion and drainage of Gd in a single nonionizing investigation; this investigation has practically replaced IVU for most pediatric queries (Avni et al 2002 ;Caldair et al 2007 ;Riccabona et al 2002bRiccabona et al , 2004bPerez-Brayfi eld et al 2003 ;Rohrschneider et al 2003 ;Boss et al 2006 ;Riccabona et al 2004b ).…”

Section: Obstructive Uropathymentioning

confidence: 99%

“…There are many different pediatric renal tumorsbenign conditions (such as hamartoma and angiomyolipoma, mesoblastic nephroma, ossifying renal tumor of infancy, metanephric adenoma, or juvenile reninoma) and pre-or semimalignant neoplasms such as nephroblastomatosis or cystic nephroma. Wilms' tumor and its precursors are the most common renal neoplasm in children and thus the most important entity in childhood (Riccabona 2003 ). There is a long list of other malignant renal tumors including clear cell sarcoma, malignant rhabdoid tumor, renal cell or renal medullary carcinoma, and lymphoma or leukemia.…”

Section: Other Pediatric Vascular Conditionsmentioning

confidence: 99%

The Pediatric Kidney

Riccabona

2014

Radiological Imaging of the Kidney

Self Cite

View full text Add to dashboard Cite

Children are not small adults. In the urinary tract, particularly, there are many conditions that are more or less specifi c to children which need early and reliable diagnosis in order to provide proper treatment to prevent renal damage and severe long-term sequelae such as hypertension or renal insuffi ciency. This is particularly important for all congenital urinary tract malformations and also for many other congenital renal conditions -these are often detected prenatally and, after birth, need prompt and reliable diagnostic workup at minimal invasiveness. Additionally, even in conditions that are the same or similar to adults, the specifi c needs and conditions in childhood require different imaging approaches and algorithms, partially because of each of the following reasons: the child's higher sensitivity to radiation, different physiology, different size and imaging appearance, as well as different potential of the various imaging techniques. These differences are outlined, focusing on some important diseases and queries such as congenital hydronephrosis and obstructive uropathy, impact of vesicoureteral refl ux on the kidney, imaging in infants with urinary tract infection, childhood urolithiasis and nephrocalcinosis, pediatric renal masses, as well as other miscellaneous renal conditions that may manifest in the child and indicate imaging. Additionally, specifi c needs for adapting and applying the various imaging techniques in childhood are discussed.

show abstract

“…Dynamic contrast-enhanced (CE) MRI has the potential, unique among all non-invasive modalities, to differentiate diseases that affect different portions of the vascular-nephron system [1]. In recent years, MRI has been increasingly used to evaluate renal masses [2, 3], urinary obstruction and infection [4], renal vasculature [5, 6], and the health of transplant donor and recipient kidneys [7]. In addition, renal MRI is emerging as a modality for the guidance of therapeutic interventional procedures [8].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging of Renal Disease: Recent Developments and Future Applications

Fenchel

Nael²,

Herget–Rosenthal

et al. 2006

Nephron Clin Pract

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) offers the ability to non-invasively assess parenchymal and vascular renal disease. Indications for renal MRI include the evaluation of renal masses, urinary obstruction and infection, renal vasculature, and the health of transplant kidneys. The potential of MR angiography to replace invasive conventional x-ray angiography has been recognized for many years. Recent developments in MRI resulting from fast MR systems with faster gradients, new surface coil designs and the latest sequence developments coupled with innovative contrast agent administration strategies have prompted substantial progress of MRI in the diagnosis of renal disease. The goal of this article is to present the current state of MRI in diagnosing renal disease, with an emphasis on the latest developments in the evaluation of renal vascular disease.

show abstract

Imaging of renal tumours in infancy and childhood

Cited by 60 publications

References 88 publications

Local behavior and lymph node metastases of Wilms' tumor: accuracy of computed tomography

Local behavior and lymph node metastases of Wilms' tumor: accuracy of computed tomography

The Pediatric Kidney

Magnetic Resonance Imaging of Renal Disease: Recent Developments and Future Applications

Contact Info

Product

Resources

About