Imaging of spindle cell lipoma

Jelinek, James S.; Wu, Angela; Wallace, Matthew T.; Kumar, Dhiren; Henshaw, Robert M.; Murphey, M.J.; Horn, AR; Aboulafia, Albert J.

doi:10.1016/j.crad.2019.11.020

Cited by 26 publications

(52 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of imagery is found in the differentiation between the malignant forms of fatty tumors and the benign forms; in fact unlike lipoma SCL appearance at MRI is not charactestic and easily misdiagnosed with other soft tissu mass. 10 In our case the magnetic resonance imaging suspected that the mass was a liposarcoma.…”

Section: Discussionmentioning

confidence: 56%

“…By immunohistochemistry, although the spindle cells in spindle cell lipoma are consistently positive for CD34 it is also the same in other lipomatous and nonlipomatous soft tissue tumors; thus, this marker has a small role in the diagnosis of spindle cell lipoma wich is established primarily on histologic findings. 10,12 Surgical excision is the treatment of choice when the patient is symptomatic. 3 Marginal excision is described for well-circumscribed lesions and wide excision with free margin is necessary for the infiltrative types, which will help in preventing recurrences.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Geant spindel cell lipoma atypically located: a case report

Mizouni¹

2020

MOJCR

View full text Add to dashboard Cite

Spindle cell lipoma is a histologically distinct variant of lipoma characteristically arising in the subcutis of the posterior neck, upper back, or shoulder. They rarely reach a size more than 2-3cms. In this article, we describe a case of a patient with geant spindle cell lipoma localized in atypical location. A 69-year-old male patient consulted because of a soft tissue mass in the right gluteus gradually increasing in size over the past 3 years. Magnetic resonance imaging (MRI) revealed a lipomatous tumor within the right gluteal muscle. The tumor was 10cmx7cm and was excised completely at surgery. The pathological diagnosis was intramuscular spindle cell lipoma and immunohistochemical study revealed all spindle cells were strongly positive for CD34. Spindle cell lipoma (SCL) is a relatively rare adipocytic neoplasm that classically arise in the trunk, lower extremities, and distal upper extremities of older male patients. Most of them measure less than 2.5cm. The large and deep seated lipomas represent a real diagnostic and therapeutic challenge as they can be confused with a well-differentiated low grade liposarcoma or other lipomatous neoplasms.

show abstract

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Geant spindel cell lipoma atypically located: a case report

Mizouni¹

2020

MOJCR

View full text Add to dashboard Cite

show abstract

“…However, because SCLs range from fat-rich to fat-free, the MRI findings are variable and complex. 5 The fat content on MRI was more than 75% in 35% of the SCLs examined by Kirwadi et al and more than 90% in 26% of those examined by Jelinek et al 5,6 Cases without fatty lesions have also been reported, accounting for 18% to 19% of SCLs. 5,6 In addition, various degrees of gadolinium enhancement have been observed.…”

Section: Discussionmentioning

confidence: 97%

“…[2][3][4] In addition, magnetic resonance imaging (MRI) has revealed the diversity of SCL composition, which ranges from fat-rich to fat-free and includes mixtures of fibrous and myxoid elements. 5,6 Ossification can also occur in soft tissue tumors and may reflect malignant potential. 7 For these reasons, SCLs are difficult to differentiate from lipomatous and non-lipomatous tumors and especially from atypical lipomatous tumors/welldifferentiated liposarcomas (ALTs/WDLs).…”

Section: Introductionmentioning

confidence: 99%

Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report

et al. 2021

View full text Add to dashboard Cite

Although spindle cell lipoma (SCL) is a subtype of lipoma, the characteristics of SCL are observed in both lipomatous and non-lipomatous tumors. In this article, we present a case of SCL with ossification mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALTs/WDLs). Considering the findings of magnetic resonance imaging and needle biopsy, which exhibited ALTs/WDLs, marginal resection was performed. Histopathological findings demonstrated mature adipocytes and spindle cells without atypia and no malignant osteoid tissue in the ossified region. In addition, immunohistochemistry (IHC) showed positive staining for CD34, heterogeneous retinoblastoma protein deficiency, and negative staining for mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase. Fluorescence in-situ hybridization showed negative amplification of MDM2. The final diagnosis of the tumor was established using IHC as an extremely rare SCL with ossification.

show abstract

“…In addition, diffuse lipoblastoma is now the preferred term for lipoblastomatosis. Of the benign adipocytic STT, spindle cell/pleomorphic lipoma can be challenging to accurately diagnose on imaging due to variable imaging appearances, lack of macroscopic fat on MRI or computed tomography (CT), and an overlapping imaging appearance with STS [ 4 ]. As such, although a simple lipoma can be diagnosed definitively on MRI, spindle cell lipoma can be a diagnostic dilemma and requires a biopsy for definitive diagnosis.…”

Section: Adipocytic Tumoursmentioning

confidence: 99%

Revisiting the WHO classification system of soft tissue tumours: emphasis on advanced magnetic resonance imaging sequences. Part 1

Ahlawat¹,

Fayad²

2020

Pol J Radiol

View full text Add to dashboard Cite

The World Health Organisation (WHO) classification categorises musculoskeletal soft tissue tumours (STT) based on their similarity to normal adult tissue. The most recent WHO classification provides an updated scheme that in tegrates biological behaviour as a distinguishing feature in each subcategory; STTs are further subdivided as benign, intermediate (locally aggressive or rarely metastasising), and malignant. Although malignant STTs are infrequent in routine orthopaedic radiology practice, musculoskeletal radiologists must be familiar with the imaging appearance of malignant STTs and distinguish them from their benign counterparts for appropriate management. Magnetic res onance imaging (MRI) is the ideal modality for the detection, characterisation, and local staging of STT. This review will discuss the most recent updates to the WHO classification of STT that are relevant to radiologists in a routine clinical practice with MRI correlation. The utility of advanced MRI sequences such as diffusion weighted imaging, dynamic contrast enhanced sequences, and magnetic resonance spectroscopy to provide insight into the biological behaviour of various STTs is highlighted.

show abstract

Imaging of spindle cell lipoma

Cited by 26 publications

References 21 publications

Geant spindel cell lipoma atypically located: a case report

Geant spindel cell lipoma atypically located: a case report

Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report

Revisiting the WHO classification system of soft tissue tumours: emphasis on advanced magnetic resonance imaging sequences. Part 1

Contact Info

Product

Resources

About