1999
DOI: 10.1111/j.1751-1097.1999.tb01953.x
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Imaging of Spontaneous Canine Mammary Tumors Using Fluorescent Contrast Agents

Abstract: We present near-infrared frequency-domain photon migration imaging for the lifetime sensitive detection and localization of exogenous fluorescent contrast agents within tissue-simulating phantoms and actual tissues. We employ intensity-modulated excitation light that is expanded and delivered to the surface of a tissue or tissue-simulating phantom. The intensity-modulated fluorescence generated from within the volume propagates to the surface and is collected using a gain-modulated image-intensified charge-cou… Show more

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Cited by 187 publications
(89 citation statements)
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“…Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy of visceral blood supply and evaluation of bowel perfusion (1)(2)(3)(4)(5)(6)(7)(8)(9). Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”
Section: Review Articlementioning
confidence: 99%
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“…Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy of visceral blood supply and evaluation of bowel perfusion (1)(2)(3)(4)(5)(6)(7)(8)(9). Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”
Section: Review Articlementioning
confidence: 99%
“…Indocyanine green is a water-soluble anionic amphiphilic tricarbocyanine dye with a molecular weight of 774.96 Da (1)(2)(3)(4)(5)(6)(7)(8)(9). This dye can be injected into the human bloodstream with practically no adverse effects (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and becomes fluorescent upon excitation by a laser beam or by light with a wavelength in the near infra-red (NIR) spectrum (approximately 820 nm).…”
Section: Introductionmentioning
confidence: 99%
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“…Furthermore, the principle could potentially be adapted to in vivo imaging of larger animals when combined with suitable hardware and computer algorithms. Fluorescence-based imaging has been used for noninvasive lymph node mapping in rabbits (29) and detection of mammary tumors in dogs (30,31) up to 1.5 cm from tissue surface. Moreover, it has been predicted that fluorescence-assisted imaging may permit noninvasive measurements 30-40 cm deep in human tissue (32).…”
Section: Resultsmentioning
confidence: 99%
“…Hence, clinical use of NIR fluorescence likely will be limited to near-surface applications, such as intraoperative imaging. [12][13][14] A major advantage of NIR fluorescence is its compatibility with conventional microscopy, 15,16 permitting single-cell detection of stem cells in pathological specimens. Ex vivo histological detection of stem cells undoubtedly will be required in clinical trials.…”
Section: Optical Imagingmentioning
confidence: 99%