Imaging of the Brain by Nuclear Magnetic Resonance

Doyle, F. H.; Pennock, J. M.; Orr, J. S.; Gore, John C.; Bydder, Graeme M.; Steiner, R. E.; Young, I. R.; Clow, H.; Bailes, D. R.; Burl, Michael C.; Gilderdale, D. J.; Walters, P.E.

doi:10.1097/00004728-198204000-00060

Cited by 6 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Noninvasive imaging techniques have enabled repeated measurements of features of cell death at the price of spatial resolution in the same animal. Although none of the characteristics of cell death can be specifically detected with neuroimaging, some have become methods of choice for its detection, particularly magnetic resonance imaging (MRI) (Doyle et al, 1981). In addition, nuclear imaging techniques such as positron emission tomography (PET) (Kuhl et al, 1980) and single photon emission computed tomography (SPECT) (Lassen et al, 1981) provide noninvasive images of specific metabolic and molecular mechanisms related to cell death in the brain.…”

mentioning

confidence: 99%

Visualizing Cell Death in Experimental Focal Cerebral Ischemia: Promises, Problems, and Perspectives

Zille

Farr

Przesdzing

et al. 2011

J Cereb Blood Flow Metab

126

View full text Add to dashboard Cite

One of the hallmarks of stroke pathophysiology is the widespread death of many different types of brain cells. As our understanding of the complex disease that is stroke has grown, it is now generally accepted that various different mechanisms can result in cell damage and eventual death. A plethora of techniques is available to identify various pathological features of cell death in stroke; each has its own drawbacks and pitfalls, and most are unable to distinguish between different types of cell death, which partially explains the widespread misuse of many terms. The purpose of this review is to summarize the standard histopathological and immunohistochemical techniques used to identify various pathological features of stroke. We then discuss how these methods should be properly interpreted on the basis of what they are showing, as well as advantages and disadvantages that require consideration. As there is much interest in the visualization of stroke using noninvasive imaging strategies, we also specifically discuss how these techniques can be interpreted within the context of cell death.

show abstract

mentioning

confidence: 99%

Visualizing Cell Death in Experimental Focal Cerebral Ischemia: Promises, Problems, and Perspectives

Zille

Farr

Przesdzing

et al. 2011

J Cereb Blood Flow Metab

126

View full text Add to dashboard Cite

show abstract

“…During the brief period for which MRT has been in existence, magnetic resonance tomographic investigations of the cranial region have already been described in numerous publications [2,3,5,8,9,21,22]. The most comprehensive study has been performed by Bydder et al [5], who report on 140 MRT investigations of the brain.…”

Section: Mr Diagnosis Of Intracranial Lesionsmentioning

confidence: 99%

“…Consensus prevails that the distinct contrast between the grey and white matter is a major advantage of the method [4,9,21].…”

Section: Differentiation Of the Grey And White Matter In The Brainmentioning

confidence: 99%

Magnetic resonance tomography (MRT) of intracranial tumours: Initial experience with the use of the contrast medium gadolinium-DTPA

et al. 1984

View full text Add to dashboard Cite

The present study provides an introduction to the clinical diagnosis of intracranial lesions by means of magnetic resonance tomography (MRT). The demonstration of different tissue qualities (bone and bone marrow, cerebral cortex and medulla, ventricular system (CSF), blood, tumour and perifocal oedema) in the MR tomogram is explained. The principles of specific MRT contrast media and their clinical application in brain tumours are discussed in detail.

show abstract

“…The CT scanning introduced by Hounsfield in 1973 1,10,11 and the nuclear MR imaging workers in 1978 and described in detail by Doyle, et al, 6 in 1981 represent the "gold standard" for diagnosis and follow up of brain tumors. The use of the operating microscope has become a standard part of the technique in most intracranial procedures since the 1960s.…”

mentioning

confidence: 99%

Prognosis of gliomas in the 1970s and today

Oertel

Buttlar²,

Schroeder³

et al. 2005

FOC

View full text Add to dashboard Cite

The benefit of the current strategy for diagnosis (magnetic resonance [MR] imaging) and treatment (surgery, chemotherapy, radiotherapy) of gliomas, in contrast to the standard treatment in use before MR imaging and the micro-surgical era, has not yet been determined. A retrospective statistical analysis was performed for all patients with glioma who underwent surgery at a single institution between 1965 and 1974 (Group I, 88 patients) or 1986 and 1995 (Group II, 249 patients). There were no major differences in symptomatology, tumor localization, and number of surgical procedures. The mean time until tumor diagnosis was significantly shorter in Group II (Group I, 48 weeks; Group II, 19.5 weeks). Also, the mean time from initial symptoms to surgery was significantly shorter for high-grade gliomas in Group II (Group I, 16.3 weeks; Group II, 11.7 weeks). For high- as well as low-grade gliomas, there was a clear reduction of the perioperative morbidity and mortality rates in Group II. Nevertheless, for the postoperative duration of survival, no significant differences were demonstrated for high- or low-grade gliomas. Based on the results of this study, the perioperative morbidity and mortality rate as well as the time from diagnosis to treatment have been remarkably reduced within the last 30 years. Nevertheless, the overall prognosis for patients with gliomas has not changed from the 1970s until today. Thus, the introduction of modern diagnostic modalities and surgical procedures has not improved the outcome in patients with glioma. Further research to improve the treatment of this disease is urgently needed.

show abstract

Imaging of the Brain by Nuclear Magnetic Resonance

Cited by 6 publications

References 0 publications

Visualizing Cell Death in Experimental Focal Cerebral Ischemia: Promises, Problems, and Perspectives

Visualizing Cell Death in Experimental Focal Cerebral Ischemia: Promises, Problems, and Perspectives

Magnetic resonance tomography (MRT) of intracranial tumours: Initial experience with the use of the contrast medium gadolinium-DTPA

Prognosis of gliomas in the 1970s and today

Contact Info

Product

Resources

About