imaging osteomyelitis

Aliabadi, Piran; Nikpoor, Nayer

doi:10.1002/art.1780370503

Cited by 26 publications

(15 citation statements)

References 15 publications

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“…Osteomyelitis is a serious infectious disease characterized by progressive bone destruction and formation (1,19). In most cases, chronic osteomyelitis requires the administration of antibiotic drugs for prolonged periods and sometimes surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging

et al. 2012

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Osteomyelitis remains a serious problem in the orthopedic field. There are only a few animal models in which the quantity and distribution of bacteria can be reproducibly traced. Here, we established a real-time quantitative mouse model of osteomyelitis using bioluminescence imaging (BLI) without sacrificing the animals. A bioluminescent strain of Staphylococcus aureus was inoculated into the femurs of mice. The bacterial photon intensity (PI) was then sequentially measured by BLI. Serological and histological analyses of the mice were performed. The mean PI peaked at 3 days, and stable signals were maintained for over 3 months after inoculation. The serum levels of interleukin-6, interleukin-1␤, and C-reactive protein were significantly higher in the infected mice than in the control mice on day 7. The serum monocyte chemotactic protein 1 level was also significantly higher in the infected group at 12 h than in the control group. A significantly higher proportion of granulocytes was detected in the peripheral blood of the infected group after day 7. Additionally, both acute and chronic histological manifestations were observed in the infected group. This model is useful for elucidating the pathophysiology of both acute and chronic osteomyelitis and to assess the effects of novel antibiotics or antibacterial implants.

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Section: Discussionmentioning

confidence: 99%

Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging

et al. 2012

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“…Early signs, such as increased density in the medullary cavity replacing fatty marrow, are well visualized [4,5]; however, this finding is nonspecific, being apparent in neoplasm, fractures, irradiation, and hemorrhage [14].…”

Section: Computed Tomographymentioning

confidence: 98%

Musculoskeletal infection imaging: Past, present, and future

Restrepo

Vargas

Riascos

et al. 2005

Curr Infect Dis Rep

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Imaging plays a key role in the evaluation of patients with known or suspected musculoskeletal infection. Although conventional radiograph still remains as the initial imaging approach, it has low sensitivity and specificity in the setting of acute infection. Magnetic resonance is highly sensitive for the detection of acute osteomyelitis and septic arthritis. Computed tomography is usually reserved for guided interventional procedures (eg, aspiration or drainage) and for evaluation of sinus tracts in chronic infections. Ultrasound is useful for fluid detection in joints and soft tissues but limited in bone assessment. Nuclear medicine, with the different radiotracers currently available, is highly sensitive for the diagnosis of acute osteomyelitis. Newer radiotracers are being developed that promise high sensitivity and specificity for the detection of these pathologies.

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“…In fase tardiva l'iperaccumulo del radiodifosfonato si circoscrive nell'area colpita sfumando progressivamente verso l'osso viciniore e scomparendo pressoché completamente dai tessuti molli. In alcune forme severe ("hot") di artrite settica spesso tale focolaio è mascherato dall'intensa ipercaptazione circostante (19)(20)(21). L'intenso iperaccumulo della fase ossea che si osserva in caso di osteomielite acuta può mancare nelle forme pediatriche dove, a causa della trombosi endomidollare e della compressione esercitata dal materiale purulento a carico dei vasi arteriosi intramidollari, non è raro riscontrare delle immagini scintigraficamente fredde, vere e proprie necrosi settiche (22).…”

Section: Scintigrafiaunclassified

Transient regional osteoporosis

Massara

Orzincolo²,

Prandini³

et al. 2011

Reumatismo

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Transient osteoporosis of the hip and regional migratory osteoporosis are uncommon and probably underdiagnosed bone diseases characterized by pain and functional limitation mainly affecting weight-bearing joints of the lower limbs. These conditions are usually self-limiting and symptoms tend to abate within a few months without sequelae. Routine laboratory investigations are unremarkable. Middle aged men and women during the last months of pregnancy or in the immediate post-partum period are principally affected. Osteopenia with preservation of articular space and transitory edema of the bone marrow provided by magnetic resonance imaging are common to these two conditions, so they are also known by the term regional transitory osteoporosis. The appearance of bone marrow edema is not specific to regional transitory osteoporosis but can be observed in several diseases, i.e. trauma, reflex sympathetic dystrophy, avascular osteonecrosis, infections, tumors from which it must be differentiated. The etiology of this condition is unknown. Pathogenesis is still debated in particular the relationship with reflex sympathetic dystrophy, with which regional transitory osteoporosis is often identified. The purpose of the present review is to remark on the relationship between transient osteoporosis of the hip and regional migratory osteoporosis with particular attention to the bone marrow edema pattern and relative differential diagnosis

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imaging osteomyelitis

Cited by 26 publications

References 15 publications

Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging

Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging

Musculoskeletal infection imaging: Past, present, and future

Transient regional osteoporosis

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