Imaging particle beams for cancer treatment

Polf, Jerimy; Parodi, Katia

doi:10.1063/pt.3.2945

Cited by 38 publications

(48 citation statements)

References 16 publications

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“…Ionoacoustic range verification by overlaying the Bragg peak on an ultrasound (US) image was performed using 50 MeV protons. The recent review expands upon this summary.…”

Section: Introductionmentioning

confidence: 94%

Two‐stage ionoacoustic range verification leveraging Monte Carlo and acoustic simulations to stably account for tissue inhomogeneity and accelerator–specific time structure – A simulation study

et al. 2017

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Ionoacoustic range verification may improve current practice. Ionoacoustic range estimates can be inherently co-registered to ultrasound images of underlying anatomy. To ensure estimates are robust in clinical practice, dose maps based upon the planning CT should be overlaid onto ultrasound volumes acquired at time of treatment and acoustic simulations re-computed to provide a database of control points and corresponding thermoacoustic emissions. Computation times for beamformed estimates are already fast enough for online range verification, but are not accurate enough for a measurement aperture limited to the surface of a transrectal ultrasound probe. Accelerated acoustic simulations will be required to enable online two-stage correction, but offline calculation is already suitable for adaptive planning.

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“…Ionoacoustic range verification by overlaying the Bragg peak on an ultrasound (US) image was performed using 50 MeV protons. The recent review expands upon this summary.…”

Section: Introductionmentioning

confidence: 94%

Two‐stage ionoacoustic range verification leveraging Monte Carlo and acoustic simulations to stably account for tissue inhomogeneity and accelerator–specific time structure – A simulation study

et al. 2017

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“…Several methods for measuring the range of the proton spot have been explored 9 . When protons interact with atomic nuclei, they give off γ-rays that can be tracked.…”

Section: Clinical Utilitymentioning

confidence: 99%

Three ways to make proton therapy affordable

Bortfeld

Loeffler

2017

Nature

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“…Instead of using eqs. (12) and (16), this special solution is easier to find directly by requiring charge neutrality condition fulfilled identically downstream, eq. (3)…”

Section: A Boltzmannian Electronsmentioning

confidence: 99%

“…Such investigation is beyond the scope of the present paper. We merely mention here that from the perspective of the proton/carbon radiation therapy, for example, the beam energy deposition is largely a collective phenomenon (e.g., [16] and referenced therein). If so, then the beam energy density ρV 2 b /2 is probably more relevant than the individual particle energy, m i V 2 b /2.…”

Section: A Acceleration Of Reflected Ionsmentioning

confidence: 99%

Ion-acoustic shocks with self-regulated ion reflection and acceleration

et al. 2016

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An analytic solution describing an ion-acoustic collisionless shock, self-consistently with the evolution of shock-reflected ions, is obtained. The solution extends the classic soliton solution beyond a critical Mach number, where the soliton ceases to exist because of the upstream ion reflection. The reflection transforms the soliton into a shock with a trailing wave and a foot populated by the reflected ions. The solution relates parameters of the entire shock structure, such as the maximum and minimum of the potential in the trailing wave, the height of the foot, as well as the shock Mach number, to the number of reflected ions. This relation is resolvable for any given distribution of the upstream ions. In this paper, we have resolved it for a simple "box" distribution. Two separate models of electron interaction with the shock are considered. The first model corresponds to the standard Boltzmannian electron distribution in which case the critical shock Mach number only insignificantly increases from M ≈ 1.6 (no ion reflection) to M ≈ 1.8 (substantial reflection).The second model corresponds to adiabatically trapped electrons. They produce a stronger increase, from M ≈ 3.1 to M ≈ 4.5. The shock foot that is supported by the reflected ions also accelerates them somewhat further. A self-similar foot expansion into the upstream medium is also described analytically.

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Imaging particle beams for cancer treatment

Abstract: Proton and carbon-ion radiotherapy are powerful tools for killing tumor cells, but only if the particles deposit their energy where they’re supposed to.

Cited by 38 publications

References 16 publications

Two‐stage ionoacoustic range verification leveraging Monte Carlo and acoustic simulations to stably account for tissue inhomogeneity and accelerator–specific time structure – A simulation study

Two‐stage ionoacoustic range verification leveraging Monte Carlo and acoustic simulations to stably account for tissue inhomogeneity and accelerator–specific time structure – A simulation study

Three ways to make proton therapy affordable

Ion-acoustic shocks with self-regulated ion reflection and acceleration

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