Imaging performance of phase-contrast breast computed tomography with synchrotron radiation and a CdTe photon-counting detector

Sarno, Antonio; Mettivier, Giovanni; Golosio, Bruno; Oliva, Piernicola; Spandre, G.; Lillo, Francesca Di; Fedon, Christian; Longo, Renata; Russo, Paolo

doi:10.1016/j.ejmp.2016.04.011

Cited by 53 publications

(40 citation statements)

References 39 publications

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“…Clinical dual-energy CT is typically performed using either dual-source [1], kVp switching [2][3][4], or dual-layered detectors [5,6]. More recently there has been development of pre-clinical systems which utilise energy discriminating photon counting detectors to provide up to eight channels of energy information [7][8][9][10]. The MARS (Medipix All Resolution System) is a spectral CT system based on the Medipix3RX photon counting detector.…”

Section: Introductionmentioning

confidence: 99%

MARS-MD: rejection based image domain material decomposition

et al. 2018

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A : This paper outlines image domain material decomposition algorithms that have been routinely used in MARS spectral CT systems. These algorithms (known collectively as MARS-MD) are based on a pragmatic heuristic for solving the under-determined problem where there are more materials than energy bins. This heuristic contains three parts: (1) splitting the problem into a number of possible sub-problems, each containing fewer materials; (2) solving each sub-problem; and (3) applying rejection criteria to eliminate all but one sub-problem's solution. An advantage of this process is that different constraints can be applied to each sub-problem if necessary. In addition, the result of this process is that solutions will be sparse in the material domain, which reduces crossover of signal between material images. Two algorithms based on this process are presented: the Segmentation variant, which uses segmented material classes to define each subproblem; and the Angular Rejection variant, which defines the rejection criteria using the angle between reconstructed attenuation vectors.

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Section: Introductionmentioning

confidence: 99%

MARS-MD: rejection based image domain material decomposition

et al. 2018

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“…These techniques are implemented at higher photon energies compared to the mammography x-ray imaging (Bisogni et al 2007, Lindfors et al 2008, Zhao et al 2012, Sarno et al 2016, Ghani et al 2017, 2018. To successfully design and manufacture such phantoms the properties of the available printing materials need to be investigated.…”

Section: Danail Ivanovmentioning

confidence: 99%

Suitability of low density materials for 3D printing of physical breast phantoms

et al. 2018

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Breast physical phantoms are a basic tool for the assessment and verification of performance standards in daily clinical practice of x-ray breast imaging modalities. They are also invaluable in testing and evaluation of new x-ray breast modalities to be potentially established, e.g. breast computed tomography, dual-energy breast CT and phase-contrast mammography and tomography. Nowadays, there is a lack or there are only a limited number of breast physical phantoms available for this purpose.The aim of this study is to explore a range of 3D printing materials such as resins, PLA, ABS, Nylon etc, to determine their attenuation and refractive properties, and to finally compare them to the properties of the breast tissues: adipose, glandular and skin.To achieve this goal, step-wedge phantoms were computationally modeled and then manufactured using stereolithographic and fused-deposition modeling technologies. X-ray images of the phantoms were acquired, using monochromatic beam at ID17, ESRF, Grenoble for three energies-30 keV, 45 keV and 60 keV. Experimental data were further processed to obtain the linear attenuation coefficients of these materials. Comparison with theoretical data for the linear attenuation coefficients and the refractive indexes for breast tissues was performed.From the studied materials, most of the resins, Nylon, Hybrid, PET-G show absorption properties close to the glandular tissue, while ABS shows absorption characteristics close to these of the adipose tissue. For phase-contrast imaging, it turns out that the ABS combined with resin-based materials to represent the adipose and glandular tissues, respectively may be a good combination for manufacturing of a phantom suitable for these studies.These results can be used for the design and the construction of a new physical anthropomorphic phantom of the breast with improved anatomical and radiological characteristics dedicated for advanced mammography imaging techniques implemented at higher photon energies.

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“…In our investigation, the sampling efficiency for the phase retrieved image was about 42% (10.6 lp/mm/25 lp/mm) as compared to the 62% efficiency for the phase sensitive image, a 32% reduction in sampling efficiency. Other single-distance phase retrieval methods have reported a reduction of more than 60% in their retrieved images as compared to phase sensitive images [52]. Thus, this retrieval method offers the advantage of offering the quantitative information while working with the polychromatic x-ray beams without greatly degrading the spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

Impact of a single distance phase retrieval algorithm on spatial resolution in X-ray inline phase sensitive imaging

Ghani

Gregory

Omoumi

et al. 2019

BSI

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A single-projection based phase retrieval method based on the phase attenuation duality principle (PAD) was used to compare the spatial resolution of the acquired phase sensitive and PAD processed phase retrieved images. An inline phase sensitive prototype was used to acquire the phase sensitive images. The prototype incorporates a micro-focus x-ray source and a flat panel detector with a 50 μm pixel pitch. A phantom composed of a 2 cm thick 50-50 adipose-glandular mimicking slab sandwiched with a 0.82 cm thick slanted PMMA sharp edge was used. Phase sensitive image of the phantom was acquired at 120 kV, 3.35 mAs with a 16 μm tube focal spot size under a geometric magnification (M) of 2.5. The PAD based method was applied to the acquired phase sensitive image for the retrieval of phase values. With necessary data processing, modulation transfer function (MTF) curves were determined for the estimation and comparison of the spatial resolution. The PAD processed phase retrieved values of the phantom were in good agreement with the theoretically calculated values. Phase sensitive images showed higher spatial resolution at all spatial frequencies compared to the phase retrieved images. It was noted that the highfrequency signal components in the retrieved image were suppressed that resulted in lower MTF values. When compared to the phase sensitive image, the cutoff resolution (10% MTF) for phase retrieved image dropped 32% from 15.6 lp/mm (32 μm) to 10.6 lp/mm (47 μm). The resolution offered by this phase sensitive prototype is radiographically enough to detect breast cancer.

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Imaging performance of phase-contrast breast computed tomography with synchrotron radiation and a CdTe photon-counting detector

Cited by 53 publications

References 39 publications

MARS-MD: rejection based image domain material decomposition

MARS-MD: rejection based image domain material decomposition

Suitability of low density materials for 3D printing of physical breast phantoms

Impact of a single distance phase retrieval algorithm on spatial resolution in X-ray inline phase sensitive imaging

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