Imaging predictor of ophthalmic involvement in maxillary sinus cancer during super selective intra-arterial cisplatin infusion and concomitant radiotherapy (RADPLAT)

Ashida, Hirokazu; Igarashi, Takao; Nozawa, Yosuke; Munetomo, Yohei; Higuchi, Takahiro; Yamauchi, Hideomi; Baba, Akira; Abe, Yukiko; Shimura, Eiji; Kessoku, Hisashi; Nishiya, Yukio; Kojima, Hiromi; Ojiri, Hiroya

doi:10.1186/s13005-021-00285-z

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…This effective procedure might be useful to avoid highly invasive surgery (58). However, the published studies refer to small patient samples (56)(57)(58)(59). The introduction of technological innovations has allowed a significant expansion of outpatient rhinology (60).…”

Section: Super-selective Intra-arterial Infusion Of Chemotherapy With Concomitant Radiotherapymentioning

confidence: 99%

“…It was developed in order to overcome some patients' problems related to advanced MSC surgical procedures, such as impaired facial function and significant facial deformity. Moreover, it is useful therapeutic strategy also for those patients with stage T4b MSC for which there is no indication of surgical resection ( 56 , 57 ). The super-selective intra-arterial chemotherapy with radiation therapy reflects a precision medicine approach associated with a low risk of side effects.…”

Section: Technological Innovationmentioning

confidence: 99%

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Pharmacological, Technological, and Digital Innovative Aspects in Rhinology

et al. 2021

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Innovation refers to the introduction of a product, a process, a service or a solution resulting in something new or significantly improved compared to the already available alternatives. In the clinical context, it is strictly related to the identification of a new added value in terms of quality, therapeutic efficacy and safety. Over the years several innovative approaches have been introduced in the clinical practice, revolutionizing the treatment and the management of important rhinologic conditions. Innovative tools, including new drugs, biomaterials, and mobile applications seem to be able to improve the clinical outcomes and the quality of life of many patients affected by (often relapsing) rhinologic diseases. Among the main modern pharmacological innovations, mention must be made of the biological drugs like monoclonal antibodies (mAbs). Recently, new mAbs have been introduced and investigated as useful arms in the treatment of some inflammatory/infectious or oncological diseases affecting the nasal cavities and paranasal sinuses. The already approved or still investigated mAbs work inhibiting different type 2 inflammation pathways, including those mediated by IgE (omalizumab), IL-4/IL-13 (dupilumab), and IL-5 (mepolizumab). Moreover, considering the higher expression of PD-L1 in nasopharyngeal carcinoma, the use of PD-1 inhibitors, such as nivolumab, or a dual CTLA-4/PD-1 blockade (ipilimumab plus nivolumab) appear to be an effective strategy for the treatment of this cancer form. The implants with bio-absorbable biomaterials represent new interesting available technological innovations. Moreover, advanced technologies such as the artificial intelligence, the machine learning as well as the augmented or virtual reality have also proved useful in rhinologic field with main impacts on precision medicine and surgery. Finally, the development and use of mobile-Health tools represent a winning strategy in monitoring of the therapy success, safety and tolerability as well as the progress of chronic disease including chronic rhinosinusitis with nasal polyps. Supporting the research of innovative tools and strategies (including pharmacological, technologic, or digital ones) is essential to improve the management of chronic diseases that significantly affect the patients' quality of life.

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Section: Super-selective Intra-arterial Infusion Of Chemotherapy With Concomitant Radiotherapymentioning

confidence: 99%

Section: Technological Innovationmentioning

confidence: 99%

Pharmacological, Technological, and Digital Innovative Aspects in Rhinology

et al. 2021

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Post-treatment magnetic resonance imaging predicts outcomes of maxillary sinus cancer treatment using super-selective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (RADPLAT)

Yamauchi,

Baba,

Ogino

et al. 2024

Auris Nasus Larynx

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Intra-arterial chemotherapy for locally advanced nasal cavity and sinonasal tract cancers

Vyzhigina,

Kropotov,

Dolgushin

et al. 2024

Opuholi golovy i šei

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Introduction. Malignant tumors of the nasal cavity and sinonasal tract are rare, less than 3 % of all of the head and neck malignant neoplasm. The leading treatment is combined methods with surgery as a first step. However, operation is limited in a locally advanced process due to requires the use of complex reconstructive techniques and removal of aesthetic and functionally important structures. In this regard, the interest of specialists is understandable in use of organ-preserving techniques with comparable oncological results. Intra-arterial chemotherapy has shown high effectiveness in various localizations of malignant neoplasms, so its use in locally advanced tumors of the nasal cavity and sinonasal tract seems promising. Aim. To evaluate the results of complex treatment of patients with locally advanced cancer of the nasal cavity and sinonasal tract using induction intra-arterial chemotherapy. Materials and methods. The study included 28 from 2017 to 2023 with locally advanced cancer of the nasal cavity and sinonasal tract underwent Tpf induction intra-arterial chemotherapy, followed by radiation or chemoradiotherapy. The primary endpoint of the study was survival, secondary – objective response rate, treatment toxicity and the possibilityof organ preservation. Results. The median follow-up was 19.1 months. we obtained results for all patients of 1-year overall survival – 85.7 % (T3 – 100 %, T4a – 92.7 %, T4b – 55.6 %), and 1-year progression-free survival – 66.7 % (T3 – 75 %, T4a – 71.4 %, T4b – 50 %), respectively. The response rate after intra-arterial chemotherapy was 85.2 %. Overall survival and progression-free survival did not differ significantly between patients with complete response, partial response, and stable disease. However, in patients with a complete response after chemoradiotherapy, 1-year overall survival was 100 % (p = 0.009) and progression-free survival – 90 % (p <0.001). The main side effect in patients in the study was the development of neutropenia (35.7 %), and occurrence of neurological complications was noted in 10.7 %. Of the 35.7 % of patients with tumor orbital invasion, survival with preserved visual function in the first year of life was 80 %; all patients retained vision; as a result of treatment, not a single patient underwent surgery with exenteration. Conclusion. Induction intra-arterial chemotherapy in treatment of patients with locally advanced cancer of the nasal cavity and sinonasal tract demonstrates high efficiency and a high level of complete responses with a fairly low level of toxicity, and also allows preserve the eye function for the majority of patients.

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Imaging predictor of ophthalmic involvement in maxillary sinus cancer during super selective intra-arterial cisplatin infusion and concomitant radiotherapy (RADPLAT)

Cited by 3 publications

References 17 publications

Pharmacological, Technological, and Digital Innovative Aspects in Rhinology

Pharmacological, Technological, and Digital Innovative Aspects in Rhinology

Post-treatment magnetic resonance imaging predicts outcomes of maxillary sinus cancer treatment using super-selective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (RADPLAT)

Intra-arterial chemotherapy for locally advanced nasal cavity and sinonasal tract cancers

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