Imaging Pulmonary Inflammation

Scherer, Philip M.; Chen, Delphine L.

doi:10.2967/jnumed.115.157438

Cited by 35 publications

(27 citation statements)

References 73 publications

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“…The underlying mechanism of inflammation is related to the activation of inflammatory cells which secrete inflammatory mediators to change the action of other types of cells (Yamada et al 2016). There are two kinds of inflammation; acute like pneumonia (Shaver et al 2016) and chronic type like asthma (Scherer and Chen 2016) which result in tissue damage (Robb et al 2016).…”

Section: Introductionmentioning

confidence: 99%

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Ali¹,

Abdel-Hamid²,

Toni³

2018

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. Hydrogen sulfide (H2S) is gasotransmitter which plays an important role in human physiology. In this study, we aimed to check the effect of H2S treatment on acute lung inflammation (ALI). Thirty-six adult male albino rats were used and divided into: control group, ALI group which was intraperitoneally (i.p.) injected with lipopolysaccharide (LPS) at a dose of 5 mg/kg body weight, ALI group treated by the H2S donor; sodium hydrosulfide (NaHS) at a dose of 10 mg/kg body weight i.p. and ALI group treated by i.p. injection of 80 mg/kg body weight DL- propargylglycine (PAG) which is an inhibitor of endogenous H2S synthesis. Serum was obtained to determine interleukin-6 (IL-6) levels. Lipid peroxides and total antioxidant capacity (TAC) levels were measured in lung. Lung histopathology and expression of inducible nitric oxide synthase (iNOS) were also done. Results showed that NaHS improved lung inflammation through its inhibitory effect on iNOS expression, decreasing the levels of IL-6 and lipid peroxides and increasing TAC levels. But, ALI was exacerbated with PAG administration. In conclusion, the results proved that H2S has a protective effect against LPS induced ALI due to its anti-nitrative, anti-oxidant and anti-inflammatory properties.

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Section: Introductionmentioning

confidence: 99%

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Ali¹,

Abdel-Hamid²,

Toni³

2018

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“…To isolate the 18 F-FDG uptake by parenchymal and immune or inflammatory cells, different methods have been proposed to account for regional variations in the fractions of air, blood, and water, which can vary dramatically with each lung disease. Accounting for these variations will apply equally to new molecular imaging tracers that can measure the activity of specific aspects of lung inflammation or other processes such as fibrosis or endothelial cell activity, as recently reviewed (12,13).…”

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confidence: 99%

Quantification of Lung PET Images: Challenges and Opportunities

et al. 2017

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“…What was more interesting was that the glucose uptake rate was especially higher in patients with rapidly declining pulmonary function. In a different study, the authors assessed FDG uptake in lungs of patients with chronic obstructive pulmonary disease (COPD) patients with and without chronic bronchitis ( Scherer and Chen, 2016 ). They showed increased average uptake of FDG in lungs with patients with chronic bronchitis.…”

Section: Position Emission Tomographymentioning

confidence: 99%

Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation

et al. 2020

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Pulmonary inflammation is a hallmark of several pulmonary disorders including acute lung injury and acute respiratory distress syndrome. Moreover, it has been shown that patients with hyperinflammatory phenotype have a significantly higher mortality rate. Despite this, current therapeutic approaches focus on managing the injury rather than subsiding the inflammatory burden of the lung. This is because of the lack of appropriate non-invasive biomarkers that can be used clinically to assess pulmonary inflammation. In this review, we discuss two metabolic imaging tools that can be used to non-invasively assess lung inflammation. The first method, Positron Emission Tomography (PET), is widely used in clinical oncology and quantifies flux in metabolic pathways by measuring uptake of a radiolabeled molecule into the cells. The second method, hyperpolarized 13 C MRI, is an emerging tool that interrogates the branching points of the metabolic pathways to quantify the fate of metabolites. We discuss the differences and similarities between these techniques and discuss their clinical applications.

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Imaging Pulmonary Inflammation

Cited by 35 publications

References 73 publications

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Quantification of Lung PET Images: Challenges and Opportunities

Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation

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