2020
DOI: 10.1183/13993003.02313-2020
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Imaging risk in pulmonary arterial hypertension

Abstract: ]. Pulmonary arterial hypertension (PAH) is a Janus-faced entity with, on one side, the pulmonary circulation and, on the other side, the right ventricle (RV) [1]. While the disease process is turned on at the site of the pulmonary resistive vessels, the patient symptomatology and prognosis are largely determined by RV structure and function adaptation to increased afterload [2, 3]. Yet, this important cardiac aspect of PAH pathophysiology remains insufficiently recognised. The study by GHIO et al. [4], in the… Show more

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Cited by 9 publications
(5 citation statements)
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“…Echocardiography is undoubtedly the most widely used tool for assessing RV function in clinical practice, representing a rapid and low-cost examination. It may help in RV adaptation to increased afterload evaluation and non-invasive assessment of PAH patient's status during follow up [55,56], improving prognostication [57]. Moreover, it may play a pivotal role in risk assessment and the normal right ventricular function could be the appropriate treatment goal in PAH.…”
Section: Discussionmentioning
confidence: 99%
“…Echocardiography is undoubtedly the most widely used tool for assessing RV function in clinical practice, representing a rapid and low-cost examination. It may help in RV adaptation to increased afterload evaluation and non-invasive assessment of PAH patient's status during follow up [55,56], improving prognostication [57]. Moreover, it may play a pivotal role in risk assessment and the normal right ventricular function could be the appropriate treatment goal in PAH.…”
Section: Discussionmentioning
confidence: 99%
“…Given the large amount of PAH patients (around 70%) considered at intermediate risk according to the current scores, research has been focusing on how to improve the risk stratification of this heterogenous group [ [20] , [21] , [22] , [23] , [24] ]. Studies conducted in recent years in this field have increased considerably the awareness of the importance of the RV as the major determinant of functional state and prognosis in PAH [ 25 ], showing that complete evaluation of RV function and adaptation to the increased afterload through echocardiography and CPET could improve risk assessment in this setting [ [26] , [27] , [28] ].…”
Section: Guidelines-directed Medical Management In Pulmonary Arterial...mentioning
confidence: 99%
“…Considering the close correlation between ventricular morphology and function and the pathophysiological basis of PAH, it is clear that the introduction of echocardiographic parameters within the current risk scores would provide a greater opportunity to improve prognostication [21,22].…”
Section: May Echocardiographic-imaging Represent the Missing Piece?mentioning
confidence: 99%