Imaging Techniques in Drug Development and Clinical Practice

Chang, J.C.S.; Gambhir, Sanjiv S.; Willmann, Jürgen K.

doi:10.1002/9783527634057.ch7

Cited by 2 publications

(2 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypoxia is imaged with imidazole based agents ( 18 F-MISO and 18 F-FETNIM). This is very important because strong desmoplastic reaction around pancreatic cancer leads to decreased vascular density and induces hypoxia, which in turn increases cancer drug resistance [ 4 , 54 , 55 ]. Knowing these variable can help direct specific antihypoxia therapy to improve patient response to chemotherapy or radiation, such as dose-painting technique in radiation therapy [ 40 ].…”

Section: Translational Molecular and Physiological Imaging Of Pancmentioning

confidence: 99%

Anatomical, Physiological, and Molecular Imaging for Pancreatic Cancer: Current Clinical Use and Future Implications

Chang

Schomer

Dragovich

2015

BioMed Research International

View full text Add to dashboard Cite

Pancreatic adenocarcinoma is one of the deadliest human malignancies. Early detection is difficult and effective treatment is limited. Verifying the presence of micrometastatic dissemination and vessel invasion remains elusive, limiting radiological staging once this diagnosis is made. Diagnostic imaging provides independent tools to evaluate and characterize the biologic behavior of pancreatic cancer. Conventional anatomic imaging alone with either CT or MRI yields useful information on organ involvement but is limited in providing molecular and physiological information. Molecular imaging techniques such as PET or MRS provide information on metabolic and signaling pathways. Advanced MR sequences that target physiological parameters expand imaging options to characterize these tumors. By considering the parametric data from these three imaging approaches (anatomic, molecular, and physiological) we can better define specific tumor signatures. Such parametric characterization can provide insight into tumor metabolism, cellular density, protein expression, focal perfusion, and vascular permeability of these tumors. Radiogenomics research has already demonstrated ability to obtain information about cancer's genotype and phenotype; this is without invasive procedures or surgery. Further advances in these areas of experimental imaging hold promise to enable future clinical advances in detection and therapy of pancreatic cancer.

show abstract

Section: Translational Molecular and Physiological Imaging Of Pancmentioning

confidence: 99%

Anatomical, Physiological, and Molecular Imaging for Pancreatic Cancer: Current Clinical Use and Future Implications

Chang

Schomer

Dragovich

2015

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…It constitutes a noninvasive modality that provides qualitative and quantitative information, allowing to explore physiological processes spatially and temporarily [1]. This approach becomes even more relevant towards imaging probe and even new drug development, since preclinical results based on imaging detection should be more readily translatable to clinical area [1, 2]. Additionally, preclinical imaging agrees with the three R's concept in which replacement, reduction, and refinement are the requested principles for laboratory animal use in research [3].…”

Section: Introductionmentioning

confidence: 99%

^99mTc-Radiolabeled TPGS Nanomicelles Outperform ^99mTc-Sestamibi as Breast Cancer Imaging Agent

Tesan

Nicoud

Núñez

et al. 2019

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome P glycoprotein efflux as well. Therefore, TPGS micelles combined with other copolymers have been reported in many cancer research studies as a carrier for therapeutic drugs. Their ability to reach tumoral tissue can also be exploited to develop imaging agents with diagnostic application. A radiolabeling method with 99mTc for TPGS nanosized micelles and their biodistribution in a healthy animal model as well as their pharmacokinetics and radiolabeling stability in vivo was previously reported. The aim of this work was to evaluate the performance of this radioactive probe as a diagnostic imaging agent compared to routinely available SPECT radiopharmaceutical, 99mTc-sestamibi. A small field of view gamma camera was used for scintigraphy studies using radiolabeled TPGS micelles in two animal models of breast cancer: syngeneic 4T1 murine cell line (injected in BALB/c mice) and chemically NMU-induced (Sprague-Dawley rats). Ex vivo radioactivity accumulation in organs of interest was measured by a solid scintillation counter, and a semiquantitative analysis was performed over acquired images as well. Results showed an absence of tumoral visualization in 4T1 model for both radioactive probes by gamma camera imaging. On the contrary, NMU-induced tumors had a clear tumor visualization by scintigraphy. A higher tumor/background ratio and more homogeneous uptake were found for radiolabeled TPGS micelles compared to 99mTc-sestamibi. In conclusion, 99mTc-radiolabeled TPGS micelles might be a potential SPECT imaging probe for diagnostic purposes.

show abstract

Imaging Techniques in Drug Development and Clinical Practice

Cited by 2 publications

References 139 publications

Anatomical, Physiological, and Molecular Imaging for Pancreatic Cancer: Current Clinical Use and Future Implications

Anatomical, Physiological, and Molecular Imaging for Pancreatic Cancer: Current Clinical Use and Future Implications

^99mTc-Radiolabeled TPGS Nanomicelles Outperform ^99mTc-Sestamibi as Breast Cancer Imaging Agent

Contact Info

Product

Resources

About

Imaging Techniques in Drug Development and Clinical Practice

Cited by 2 publications

References 139 publications

Anatomical, Physiological, and Molecular Imaging for Pancreatic Cancer: Current Clinical Use and Future Implications

Anatomical, Physiological, and Molecular Imaging for Pancreatic Cancer: Current Clinical Use and Future Implications

99mTc-Radiolabeled TPGS Nanomicelles Outperform 99mTc-Sestamibi as Breast Cancer Imaging Agent

Contact Info

Product

Resources

About

^99mTc-Radiolabeled TPGS Nanomicelles Outperform ^99mTc-Sestamibi as Breast Cancer Imaging Agent