Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping

Li, Jun; Li, Yufei; Gutierrez, Lorenzo; Xu, Wenying; Wu, Yiwen; Li, Dianyou; Sun, Bomin; Zhang, Chencheng; Wei, Hongjiang

doi:10.3389/fnhum.2019.00447

Cited by 26 publications

(14 citation statements)

References 44 publications

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“…Several human neurosurgery researchers have recently reported that QSM is useful for surgeries to put electrodes for deep brain stimulation (DBS) for Parkinson's disease or dystonia patients. Similar to the work shown here, these studies showed that QSM at 3T MRI (Dimov et al, 2018;Li et al, 2020;Wei et al, 2019) and 7T MRI (de Hollander et al, 2014) visualized targets of the DBS (the STN, GPi, and centromedian thalamic nucleus). For macaque research, this method, combined with T1w images for the grid in the neuronal recording chamber, will allow us to achieve more precise targeting in focusing on the subcortical was not certified by peer review) is the author/funder.…”

Section: Discussionsupporting

confidence: 87%

Visualization of subcortical structures in non-human primates in vivo by Quantitative Susceptibility Mapping at 3T MRI

Yoshida¹,

Ye²,

Yu³

et al. 2021

Preprint

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Magnetic resonance imaging (MRI) is now an essential tool in the field of neuroscience involving non-human primates (NHP). Structural MRI scanning using T1-weighted (T1w) or T2-weighted (T2w) images provides anatomical information, particularly for experiments involving deep structures such as the basal ganglia and cerebellum. However, for certain subcortical structures, T1w and T2w images fail to reveal important anatomical details. To better visualize such structures in the macaque brain, we applied a relatively new method called quantitative susceptibility mapping (QSM), which enhances tissue contrast based on the local tissue magnetic susceptibility. To evaluate the visualization of important structures, we quantified the the contrast-to-noise ratios (CNRs) of the ventral pallidum (VP), globus pallidus external and internal segments (GPe and GPi), substantia nigra (SN), subthalamic nucleus (STN) in the basal ganglia and the dentate nucleus (DN) in the cerebellum. For these structures, the QSM method significantly increased the CNR, and thus the visibility, beyond that in either the T1w or T2w images. In addition, QSM values of some structures were correlated to the age of the macaque subjects. These results indicate that the QSM method can enable the clear identification of certain subcortical structures that are invisible in more traditional scanning sequences.

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Section: Discussionsupporting

confidence: 87%

Visualization of subcortical structures in non-human primates in vivo by Quantitative Susceptibility Mapping at 3T MRI

Yoshida¹,

Ye²,

Yu³

et al. 2021

Preprint

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“…The CM was targeted in this report using indirect and direct technique as previously described ( 10 , 15 – 17 ). The CM remains difficult to demarcate on standard neuroimaging ( 36 ), however studies have shown that inverse MP2RAGE and quantitative susceptibility mapping (QSM) can be used to identify the nucleus with good reliability ( 16 , 41 ). Confirmation of electrode placement using intraoperative microelectrode recording (MER) evaluation of the CMN neurophysiological signature has shown mixed results, given the presence of low frequency firing rate while sedated, considerable interpatient variability, and subtle differences in neural signatures between adjacent thalamic nuclei ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Responsive Neurostimulation of the Centromedian Thalamic Nucleus for the Detection and Treatment of Seizures in Pediatric Primary Generalized Epilepsy

2021

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Up to 20% of pediatric patients with primary generalized epilepsy (PGE) will not respond effectively to medication for seizure control. Responsive neurostimulation (RNS) is a promising therapy for pediatric patients with drug-resistant epilepsy and has been shown to be an effective therapy for reducing seizure frequency and severity in adult patients. RNS of the centromedian nucleus of the thalamus may help to prevent loss of awareness during seizure activity in PGE patients with absence seizures. Here we present a 16-year-old male, with drug-resistant PGE with absence seizures, characterized by 3 Hz spike-and-slow-wave discharges on EEG, who achieved a 75% reduction in seizure frequency following bilateral RNS of the centromedian nuclei. At 6-months post-implant, this patient reported complete resolution of the baseline daily absence seizure activity, and decrease from 3–4 generalized convulsive seizures per month to 1 per month. RNS recordings showed well-formed 3 Hz spike-wave discharges in bilateral CM nuclei, further supporting the notion that clinically relevant ictal discharges in PGE can be detected in CM. This report demonstrates that CM RNS can detect PGE-related seizures in the CM nucleus and deliver therapeutic stimulation.

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“…24 Li et al also recently proposed the use of quantitative susceptibility mapping to identify the centromedian nucleus. 35 While promising, the lack of a 3D isotropic acquisition limits the applicability to surgical planning, as well as the requirement of complex post-processing techniques. Due to the lack of the widespread availability of MP2RAGE and quantitative susceptibility mapping, as well as the need for complex post-processing, EDGE-MICRA offers a more easily implementable approach to visualise the centromedian and parafascicular complex using widely available methods.…”

Section: Discussionmentioning

confidence: 99%

Edge-enhancing gradient echo with multi-image co-registration and averaging (EDGE-MICRA) for targeting thalamic centromedian and parafascicular nuclei

et al. 2021

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Background and purpose Deep brain stimulation of the thalamus is an effective treatment for multiple neurological disorders. The centromedian and parafascicular nuclei are recently emerging targets for multiple conditions, such as epilepsy and Tourette syndrome; however, their limited visibility on conventional magnetic resonance imaging sequences has been a major obstacle. The goal of this study was to demonstrate the feasibility of a high-resolution and high-contrast targeting sequence for centromedian-parafascicular deep brain stimulation using a recently described magnetic resonance imaging sequence, three-dimensional edge-enhancing gradient echo. Methods The three-dimensional edge-enhancing gradient echo sequence was performed on a normal volunteer for a total of six acquisitions. Multi-image co-registration and averaging was performed by first co-registering each of the six scans and then averaging to produce an edge-enhancing gradient echo-multi-image co-registration and averaging scan. The averaging was also performed for two, three, four and five scans to assess the change in the signal-to-noise ratio and identify the ideal balance of image quality and scan time. Results The edge-enhancing gradient echo-multi-image co-registration and averaging scan allowed clear boundary delineation of the centromedian and parafascicular nuclei. The signal-to-noise ratio increased as a function of increasing scan number, but the added gain was small beyond four scans for the imaging parameters used in this study. Conclusions The recently described three-dimensional edge-enhancing gradient echo sequence provides an easily implementable approach, using widely available magnetic resonance imaging technology without complex post-processing techniques, to delineate centromedian and parafascicular nuclei for deep brain stimulation targeting.

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Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping

Cited by 26 publications

References 44 publications

Visualization of subcortical structures in non-human primates in vivo by Quantitative Susceptibility Mapping at 3T MRI

Visualization of subcortical structures in non-human primates in vivo by Quantitative Susceptibility Mapping at 3T MRI

Case Report: Responsive Neurostimulation of the Centromedian Thalamic Nucleus for the Detection and Treatment of Seizures in Pediatric Primary Generalized Epilepsy

Edge-enhancing gradient echo with multi-image co-registration and averaging (EDGE-MICRA) for targeting thalamic centromedian and parafascicular nuclei

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