Imaging the effects of genetic polymorphisms on radioligand binding in the living human brain: A review on genetic neuroreceptor imaging of monoaminergic systems in psychiatry

Willeit, Matthäus; Praschak-Rieder, Nicole

doi:10.1016/j.neuroimage.2010.04.030

Cited by 81 publications

(79 citation statements)

References 242 publications

(253 reference statements)

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“…The Taq1A allele is reported as a risk factor for obesity (Blum et al, 1996;Noble, 2003) (although not consistently (Fuemmeler et al, 2008)), a risk factor for greater food reinforcement and food intake (Epstein et al, 2007) and it influences striatal brain activity on food stimuli (Stice et al, 2008). In addition, this allele has been associated with a lower striatal DRD 2 availability (Willeit and Praschak-Rieder, 2010). This fits the finding of lower striatal DRD 2 availability in obesity (de Weijer et al, 2011;Wang et al, 2001).…”

Section: Discussionsupporting

confidence: 69%

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

Giessen¹,

Hesse²,

Caan³

et al. 2013

NeuroImage

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Section: Discussionsupporting

confidence: 69%

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

Giessen¹,

Hesse²,

Caan³

et al. 2013

NeuroImage

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“…The 5-HTTLPR is a common genetic variant within the gene (SLC6A4) coding for the serotonin transporter (5-HTT) where the 'long' (L) allele exhibits increased serotonin transporter (5-HTT) transcription in vitro relative to the 'short' (S) allele, putatively affecting 5-HT signaling (Lesch et al, 1996). As discussed within a recent review of genetic sources of variability in serotonin signaling as measured with PET, there is evidence suggesting that 5-HTTLPR status is associated with individual differences in aspects of serotonin signaling (Willeit and Praschak-Rieder, 2010).…”

Section: Introductionmentioning

confidence: 99%

5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [11C]SB207145 PET in humans

et al. 2012

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“…Corresponding PET-and SPECT-studies, however, yielded contradictory results. Considering only those studies using [ 11 C]DASB, the radioligand considered to be most appropriate (Willeit and Praschak-Rieder, 2010), some found an increased serotonin transporter binding in ll-homozygotes compared to s-allele-carriers (Praschak-Rieder et al, 2007;Reimold et al, 2007;Kalbitzer et al, 2009), while Murthy et al (2010), using the largest sample, could not show a functional influence. Also Christian et al (2009) did not find any association in non-human primates, likewise pointing to no unequivocal evidence for a functional influence in vivo.…”

Section: Discussionmentioning

confidence: 99%

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality – The moderating role of the 5-HTTLPR

Wielpuetz

Kuepper

Grant

et al. 2014

Personality and Individual Differences

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According to the idea that the central serotonergic system has a modulatory function on behavior and personality in general, we aimed to highlight its association to habitual positive emotionality. In a placebo-controlled double-blind and randomized cross-over neuroendocrine challenge design (n = 72 healthy males) we investigated the association of the central serotonergic responsivity, 5-HTTLPR-genotype as well as their combined effects on positive emotionality. Regression analyses revealed an involvement of the serotonergic system in positive emotionality. There was, however, no direct association between positive emotionality and cortisol responses to S-citalopram; rather 5-HTTLPR-genotype showed an association (p < 0.05). That is, positive emotionality scores increased with the number of s-alleles carried by the individuals. Most notable was the moderating role of 5-HTTLPR-genotype (p < 0.05) on the association between acute serotonergic responsivity and positive emotionality. Indeed, this association was only found in ss-homozygotes, in which the acute responsivity of the serotonergic system additionally seems to contribute to the level of positive emotionality (r = 0.70, p < 0.05). The findings correspond to previous research demonstrating that the 5-HTTLPR is not only involved in the negative-emotional aspects of behavior and temperament, but is associated, moreover, with positive affectivity-supporting the assumption of its valence-neutrality. In addition, our data are in line with the idea of possible influences of the 5-HTTLPR-genotype on early neuronal development. They also indicate the need for further studies in order to clearly elucidate the role of the serotonergic system and its subcomponents in the regulation of positive emotionality.

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Imaging the effects of genetic polymorphisms on radioligand binding in the living human brain: A review on genetic neuroreceptor imaging of monoaminergic systems in psychiatry

Cited by 81 publications

References 242 publications

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [11C]SB207145 PET in humans

Acute responsivity of the serotonergic system to S-citalopram and positive emotionality – The moderating role of the 5-HTTLPR

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