Imaging the Molecular Footprints of the Heart–Brain Axis in Cardiovascular Disease

Thackeray, James T.

doi:10.2967/jnumed.118.222315

Cited by 16 publications

(10 citation statements)

References 15 publications

(20 reference statements)

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“…In a meta-analysis of eight studies examining the prospective associations between depressive symptoms or a depressive disorder and HF outcomes, Rutledge et al (3) found that depressive symptoms or depressive disorders were highly prevalent risk factors for cardiac death or events in patients with established HF. In line with these clinical and experimental evidence, HF and depression have shown a worsening relationship with each other, just like a vicious cycle through the heart-brain axis (HBA) (7,8).…”

Section: Introductionmentioning

confidence: 76%

Hotspot and Frontier Analysis of Exercise Training Therapy for Heart Failure Complicated With Depression Based on Web of Science Database and Big Data Analysis

Wang

Jia

et al. 2021

Front. Cardiovasc. Med.

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Background: Exercise training has been extensively studied in heart failure (HF) and psychological disorders, which has been shown to worsen each other. However, our understanding of how exercise simultaneously protect heart and brain of HF patients is still in its infancy. The purpose of this study was to take advantage of big data techniques to explore hotspots and frontiers of mechanisms that protect the heart and brain simultaneously through exercise training.Methods: We studied the scientific publications on related research between January 1, 2003 to December 31, 2020 from the WoS Core Collection. Research hotspots were assessed through open-source software, CiteSpace, Pajek, and VOSviewer. Big data analysis and visualization were carried out using R, Cytoscape and Origin.Results: From 2003 to 2020, the study on HF, depression, and exercise simultaneously was the lowest of all research sequences (two-way ANOVAs, p < 0.0001). Its linear regression coefficient r was 0.7641. The result of hotspot analysis of related keyword-driven research showed that inflammation and stress (including oxidative stress) were the common mechanisms. Through the further analyses, we noted that inflammation, stress, oxidative stress, apoptosis, reactive oxygen species, cell death, and the mechanisms related to mitochondrial biogenesis/homeostasis, could be regarded as the primary mechanism targets to study the simultaneous intervention of exercise on the heart and brain of HF patients with depression.Conclusions: Our findings demonstrate the potential mechanism targets by which exercise interferes with both the heart and brain for HF patients with depression. We hope that they can boost the attention of other researchers and clinicians, and open up new avenues for designing more novel potential drugs to block heart-brain axis vicious circle.

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Section: Introductionmentioning

confidence: 76%

Hotspot and Frontier Analysis of Exercise Training Therapy for Heart Failure Complicated With Depression Based on Web of Science Database and Big Data Analysis

Wang

Jia

et al. 2021

Front. Cardiovasc. Med.

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“…Long AFOV PET imaging has been gaining significant interest recently because of its wide scope of potential clinical applications [11], such as multiorgan simultaneous imaging (e.g., heart-brain axis [8], gut-brain axis [9], etc. ), simultaneous multiorgan kinetic modeling [10], breath-hold imaging [38], new drug dosimetry studies, etc.…”

Section: Discussionmentioning

confidence: 99%

“…P OSITRON emission tomography (PET) is a molecular imaging technique that is widely used in neurology, cardiology, and oncology [1]. One major limitation of clinical PET systems is their relatively short axial field of view (AFOV), typically <26 cm [2]- [7], hindering many applications that require simultaneous imaging of distant organs, such as imaging of the brain-heart axis [8], brain-gut axis [9], whole body kinetic parameters [10], etc. Recently, there has been an increased interest in extending the PET AFOV [11], [12].…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo Simulation of the Siemens Biograph Vision PET With Extended Axial Field of View Using Sparse Detector Module Rings Configuration

Zein

Karakatsanis

Conti

et al. 2021

IEEE Trans. Radiat. Plasma Med. Sci.

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We report on the NEMA-NU2-2012 performance of a hypothetical Monte Carlo (MC) model, Ex-PET, of the Siemens Biograph Vision positron emission tomography (PET)/CT (Bio-Vis) with sparse detector module rings and extended axial field of view (AFOV). MC simulations were performed with the detector module rings interleaved with 32-mm gaps, equivalent to the axial dimension of each detector module, yielding an AFOV of 48.0 cm (Bio-Vis has 25.6-cm AFOV). 3D-PET acquisition combined with a limited continuous-bed-motion (limited-CBM) was used to compensate for the loss in sensitivity within the gaps' regions. MC simulations of the Bio-Vis were performed for comparison purposes. All MC simulations were performed using GATE MC toolkit. Ex-PET exhibited 0.49, 0.16, and 0.16 mm deterioration in axial resolution at 1, 10, and 20 cm off-center of the transaxial field of view, respectively, compared to Bio-Vis. Only 1% reduction in system sensitivity and 6% reduction in peak NECR was observed with Ex-PET compared to Bio-Vis. 3D-OSEM image reconstruction, combined with CBM, allowed compensating for the lack of counts within the gaps' regions. NEMA Image Quality test showed <6% reduction in contrast recovery with Ex-PET versus Bio-Vis, yet the background variability was increased by up to 8%. The feasibility of PET imaging with an easily adoptable sparse detector configuration was demonstrated. This can lay the pathway for future development of cost-effective PET systems with long and conventional AFOV's. Index Terms-Continuous bed motion (CBM), extended axial field of view, Monte Carlo (MC), positron emission tomography (PET), sparse detectors.

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“…Because radionuclidebased molecular imaging is a whole-body technique, it is uniquely suited to uncover such systemic networks. The inflammatory link between heart, hematopoietic system, vessel wall, and other organs such as brain and kidneys is one timely example (26). Likewise, the recent emphasis on imaging the effects of tumors and tumor therapy on the cardiovascular system (cardio-oncology) is another example (27).…”

Section: Cardiologymentioning

confidence: 99%

The Future of Nuclear Medicine, Molecular Imaging, and Theranostics

Weber¹,

Czernin

Anderson

et al. 2020

J Nucl Med

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Imaging the Molecular Footprints of the Heart–Brain Axis in Cardiovascular Disease

Cited by 16 publications

References 15 publications

Hotspot and Frontier Analysis of Exercise Training Therapy for Heart Failure Complicated With Depression Based on Web of Science Database and Big Data Analysis

Hotspot and Frontier Analysis of Exercise Training Therapy for Heart Failure Complicated With Depression Based on Web of Science Database and Big Data Analysis

Monte Carlo Simulation of the Siemens Biograph Vision PET With Extended Axial Field of View Using Sparse Detector Module Rings Configuration

The Future of Nuclear Medicine, Molecular Imaging, and Theranostics

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