Imaging the Tumor Microenvironment

LeBleu, Valerie S.

doi:10.1097/ppo.0000000000000118

Cited by 63 publications

(45 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LeBleu [11] To provide an overview of the different cell types and physiological parameters of the tumor microenvironment and how they affect tumor development…”

Section: Systematic Reviewmentioning

confidence: 99%

“…An increasing number of studies have revealed that tumor-associated macrophages (TAMs) can augment, mediate, or antagonize the antitumor activity of irradiation, cytotoxic agents, and checkpoint inhibitors. The final cell type in the TME is the fibroblast [11,12,37]. Fibroblasts allow cancer cells to migrate from the primary tumor location into the bloodstream for systemic metastasis.…”

Section: The Tumor Microenvironmentmentioning

confidence: 99%

“…Some recent empirical studies and reviews have shown that the TME harbors carcinoma cells and sarcoma cells, as well as hematopoietic, mesenchymal, and noncellular components, that contribute to tumor heterogeneity [12,37]. For example, LeBleu noted that the TME represents a complex and dynamic milieu of both cellular and acellular components with synergistic responses and functions in cancer progression [11]. According to Korneev et al, tumors usually interact closely and continuously with the surrounding microenvironment and organs via the lymphatic or circulatory system [12].…”

Section: The Tumor Microenvironmentmentioning

confidence: 99%

“…Furthermore, tumor cells can influence the microenvironment through the release of extracellular paracrine signals that induce peripheral immune tolerance and support tumor angiogenesis [12]. Similarly, immune cells in the TME can affect the evolution, growth, and progression of cancerous cells in patients suffering from different types of cancer [11].…”

Section: The Tumor Microenvironmentmentioning

confidence: 99%

See 3 more Smart Citations

Tumor Microenvironment

2019

View full text Add to dashboard Cite

Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer. In addition, nonmalignant cells in the tumor microenvironment play critical roles in all the stages of carcinogenesis by stimulating and facilitating uncontrolled cell proliferation. Aim: This study aims to explore the concept of the tumor microenvironment by conducting a critical review of previous studies on the topic. Materials and Methods: This review relies on evidence presented in previous studies related to the topic. The articles included in this review were obtained from different medical and health databases. Results and Discussion: The tumor microenvironment has received significant attention in the cancer literature, with a particular focus on its role in tumor development and progression. Previous studies have identified various components of the tumor microenvironment that influence malignant behavior and progression. In addition to malignant cells, adipocytes, fibroblasts, tumor vasculature, lymphocytes, dendritic cells, and cancer-associated fibroblasts are present in the tumor microenvironment. Each of these cell types has unique immunological capabilities that determine whether the tumor will survive and affect neighboring cells. Conclusion: The tumor microenvironment harbors cancer stem cells and other molecules that contribute to tumor development and progression. Consequently, targeting and manipulating the cells and factors in the tumor microenvironment during cancer treatment can help control malignancies and achieve positive health outcomes.

show abstract

“…LeBleu [11] To provide an overview of the different cell types and physiological parameters of the tumor microenvironment and how they affect tumor development…”

Section: Systematic Reviewmentioning

confidence: 99%

Section: The Tumor Microenvironmentmentioning

confidence: 99%

Section: The Tumor Microenvironmentmentioning

confidence: 99%

Section: The Tumor Microenvironmentmentioning

confidence: 99%

See 2 more Smart Citations

Tumor Microenvironment

2019

View full text Add to dashboard Cite

show abstract

“…For example, determination of the best non-invasive imaging modality to use and protocol optimization for imaging the tumor microenvironment is actively being investigated and beginning to offer new insights [147]. An important area to address will be the development of methods to distinguish whether changes observed in the images of the tumor microenvironment following a liposome therapy are truly related to a response to the liposome therapy and not simply an artifact caused by perturbation of the microenvironment by the presence of the liposomes.…”

Section: Expert Opinionmentioning

confidence: 99%

Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy

Goins

Phillips

Bao

2016

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

Introduction A major limitation of current liposomal cancer therapies is the inability of liposome therapeutics to penetrate throughout the entire tumor mass. This inhomogeneous distribution of liposome therapeutics within the tumor has been linked to treatment failure and drug resistance. Both liposome particle transport properties and tumor microenvironment characteristics contribute to this challenge in cancer therapy. This limitation is relevant to both intravenously and intratumorally administered liposome therapeutics. Areas covered Strategies to improve the intratumoral distribution of liposome therapeutics are described. Combination therapies of intravenous liposome therapeutics with pharmacologic agents modulating abnormal tumor vasculature, interstitial fluid pressure, extracellular matrix components, and tumor associated macrophages are discussed. Combination therapies using external stimuli (hyperthermia, radiofrequency ablation, magnetic field, radiation, and ultrasound) with intravenous liposome therapeutics are discussed. Intratumoral convection-enhanced delivery (CED) of liposomal therapeutics is reviewed. Expert opinion Optimization of the combination therapies and drug delivery protocols are necessary. Further research should be conducted in appropriate cancer types with consideration of physiochemical features of liposomes and their timing sequence. More investigation of the role of tumor associated macrophages in intratumoral distribution is warranted. Intratumoral infusion of liposomes using CED is a promising approach to improve their distribution within the tumor mass.

show abstract

Recent Advances in Dual‐target‐activated Fluorescent Probes for Biosensing and Bioimaging

Han

Xiong

Ren

et al. 2022

Chemistry An Asian Journal

View full text Add to dashboard Cite

Fluorescent probes have been powerful tools for visualizing and quantifying multiple dynamic processes in living cells. However, the currently developed probes are often constructed by conjugation a fluorophore with a recognition moiety and given signal‐output after triggering with one singly target interest. Compared with the single‐target‐activated fluorescent probes mentioned above, the dual‐target‐activated ones, triggering with one target under stimulus (such as photoirradiation, microenvironment) or another targets, have the advantages of advoiding nonspecific activation and “false positive” results in complicated environments. In recent years, many dual‐target‐activated fluorescent probes have been developed to detect various biologically relevant species. In view of the importance of a comprehensive understanding of dual‐target‐ activated fluorescent probes, a thorough summary of this topic is urgently needed. However, no comprehensive and critical review on dual target activated fluorescent probes has been published recently. In this review, we focus on the dual‐target‐activated fluorescent probes and briefly outline their types and current state of development. In each type, the chemical structure, proposed responsive mechanism and application of probes are highlighted. At last, the challenges and prospective opportunities of every type were proposed.

show abstract

Imaging the Tumor Microenvironment

Cited by 63 publications

References 41 publications

Tumor Microenvironment

Tumor Microenvironment

Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy

Recent Advances in Dual‐target‐activated Fluorescent Probes for Biosensing and Bioimaging

Contact Info

Product

Resources

About