Imaging with 124I in differentiated thyroid carcinoma: is PET/MRI superior to PET/CT?

Binse, Ina; Poeppel, Thorsten D.; Ruhlmann, Marcus; Gomez, Benedikt; Umutlu, Lale; Bockisch, Andreas; Rosenbaum-Krumme, Sandra

doi:10.1007/s00259-015-3288-y

Cited by 39 publications

(29 citation statements)

References 21 publications

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“…MR was performed simultaneously before and after administration of contrast medium (0.2 mL/kg body weight Dotarem; Guerbet GmbH, Sulzbach, Germany) using a head-and-neck coil. Attenuation correction was based on an automatically generated four-compartment model attenuation map (μ-map) derived from a two-point T1-W Dixon VIBE (volumetric interpolated breath-hold examination) sequence [ 12 ]. Standard corrections for random coincidence, scatter, and dead time were performed.…”

Section: Methodsmentioning

confidence: 99%

Quantitative performance of 124I PET/MR of neck lesions in thyroid cancer patients using 124I PET/CT as reference

et al. 2018

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BackgroundIn patients with differentiated thyroid cancer (DTC), serial 124I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they are close to or surrounded by different tissue types. In contrast to PET/CT, MR-based attenuation correction in PET/MR may be therefore challenging in the neck region. The aim of this retrospective study was to assess the quantitative performance of 124I PET/MRI of neck lesions by comparing the MR-based and CT-based 124I activity concentrations (ACs). Sixteen DTC patients underwent PET/CT scans at 24 and 120 h after administration of about 25 MBq 124I. Approximately 1 h before or after PET/CT examination, each patient additionally received a 24-h PET/MR scan and sometimes a 120-h PET/MR scan. PET images were reconstructed using the respective attenuation correction approach. Appropriate reconstruction parameters and corrections were used to harmonize the reconstructed PET images to provide, for instance, similar spatial resolution. For each lesion, two types of ACs were ascertained: the maximum AC (max-AC) and an average AC (avg-AC). The avg-AC is the average activity concentration obtained within a spherical volume of interest with a diameter of 7 mm, equaling the PET scanner resolution. For each type of AC, the percentage AC difference between MR-based and CT-based ACs was determined and Lin’s concordance correlation analysis was applied. Quantitative performance was considered acceptable if the standard deviation was ± 25% (precision), and the mean value was within ± 10% (accuracy).ResultsThe avg-ACs (max-ACs within parentheses) of 74 lesions ranged from 0.20 (0.33) to 657 (733) kBq/mL. Excluding two lesions with ACs of approximately 1 kBq/mL, the mean (median) ± standard deviation (range) was − 4% (− 5%) ± 14% (− 28 to 29%) for the avg-AC and − 9% (− 11%) ± 14% (− 33 to 33%) for the max-AC. Lin’s concordance correlation coefficients were ≥ 0.97, indicating substantial AC agreement.ConclusionsQuantification of lesions in the neck region using 124I PET/MR showed acceptable quantitation performance to 124I PET/CT for AC above 1 kBq/mL. The PET/MRI-based 124I ACs in the neck region can be therefore reliably used in pre-therapy dosimetry planning.

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Section: Methodsmentioning

confidence: 99%

Quantitative performance of 124I PET/MR of neck lesions in thyroid cancer patients using 124I PET/CT as reference

et al. 2018

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“…To date, studies regarding the efficacy of PET/MR in thyroid carcinoma have rarely been reported. Initially, Binse et al (19) reported that the detection rate of iodine-positive metastasis in PET/MR was superior to that in PET/CT. On the other hand, Dercle et al (20) reported that PET/MR does not show any advantage over PET/CT in detecting primary diseases of the neck.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of PET/MR for Evaluating Central Lymph Node Status in Patients with Papillary Thyroid Carcinoma

et al. 2017

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Purpose: Ultrasonography and computed tomography of the neck are commonly used for preoperative evaluation of neck lymph node (LN) status in papillary thyroid carcinoma (PTC). This study evaluated the accuracy of preoperative positron emission tomography/magnetic resonance (PET/MR) imaging of cervical LN status in PTC. F-fluorodeoxyglucose uptake and preoperative morphologic abnormalities of nodal shape, cortical thickness, and the fatty hilum of neck nodes were analyzed using PET/MR imaging. Results: Total thyroidectomy and lobectomy were conducted in 78.2% (223/285) and 21.8% (62/285) of cases, respectively. The status of central neck LN were evaluated in all patients during surgery and additional evaluation of lateral neck LN were conducted in 11.9% (34/285) of patients through selective sampling or modified radical neck dissection. In total, 36.1% (103/285) of patients had pathologic neck LN metastasis (LNM). PET/MR imaging showed an accuracy of 68.8%, sensitivity of 32.7%, and specificity of 88.6% for the detection of central neck LNM; moreover, an accuracy of 95.1%, sensitivity 68.4%, and specificity of 97.0% for lateral neck LNM. PET/MR imaging showed higher accuracy for detecting neck LNM in the 164 patients who did not have suspected clinical thyroiditis than others. Conclusion: PET/MR has a high specificity for detecting central LNM, especially for patients diagnosed with PTC without pathologic thyroiditis.

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“…First, iodine natively has high affinity with thyroid tissue. Binse et al [ 13 ] clearly visualized metastatic lesions in patients with differentiated thyroid cancer (DTC) using 124 I and PET/CT or PET/MRI. PET imaging using 124 I will greatly contribute to the management of patients with high-risk DTC.…”

Section: Radionuclide—iodine-124mentioning

confidence: 99%

Topics of nuclear medicine research in Europe

et al. 2017

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Last year in the European Journal of Nuclear Medicine and Molecular Imaging, we introduced some recent nuclear medicine research conducted in Japan. This was favorably received by European readers in the main. This year we wish to focus on the Annals of Nuclear Medicine on some of the fine nuclear medicine research work executed in Europe recently. In the current review article, we take up five topics: prostate-specific membrane antigen imaging, recent advances in radionuclide therapy, [18F]fluorodeoxyglucose positron-emission tomography (PET) for dementia, quantitative PET assessment of myocardial perfusion, and iodine-124 (124I). Just at the most recent annual meeting of the European Association of Nuclear Medicine 2016, Kyoto was selected as the host city for the 2022 Congress of the World Federation of Nuclear Medicine and Biology. We hope that our continuous efforts to strengthen scientific cooperation between Europe and Japan will bring many European friends and a great success to the Kyoto meeting.

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Imaging with 124I in differentiated thyroid carcinoma: is PET/MRI superior to PET/CT?

Cited by 39 publications

References 21 publications

Quantitative performance of 124I PET/MR of neck lesions in thyroid cancer patients using 124I PET/CT as reference

Quantitative performance of 124I PET/MR of neck lesions in thyroid cancer patients using 124I PET/CT as reference

Diagnostic Accuracy of PET/MR for Evaluating Central Lymph Node Status in Patients with Papillary Thyroid Carcinoma

Topics of nuclear medicine research in Europe

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