Imagistic and histopathologic concordances in degenerative lesions of intervertebral disks

Cevei, Mariana; Stoicanescu, Dorina; Lazăr, Liviu; Roşca, Elena

doi:10.1016/j.bone.2010.04.155

Cited by 6 publications

(9 citation statements)

References 25 publications

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“…Electron microscopy of degenerative lumbar discs revealed a slight global increase in collagen III in some specimens, whereas a variety of changes, including increases in collagen III in NP cells, increase of collagen III in AF cells, and presence of collagen III in cartilaginous endplates, could be observed in other specimens (Cevei et al, 2011).…”

Section: Collagen IIImentioning

confidence: 92%

“…Collagen V is found in the outer part of the AF together with other collagens, including types I, II, and VI. With aging and disc degeneration, collagen V increases slightly in NP cells, moderately in AF cells, and also is expressed in endplates (Cevei et al, 2011;Eskola, 2012). Collagen V up-regulation in cartilaginous endplates may be a nonspecific finding common to several collagens found in many lumbar disc lesions (Cevei et al, 2011).…”

Section: Collagen Vmentioning

confidence: 99%

“…Collagen IV is up-regulated in early-onset degenerated IVDs in patients between 16 and 30 years of age. Collagen IV up-regulation occurred in both NP and AF and may be one cause of early degeneration (Cevei et al, 2011;Eskola, 2012).…”

Section: Other Collagensmentioning

confidence: 99%

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Genetic aspects of intervertebral disc degeneration

Hanaei

Abdollahzade

Khoshnevisan

et al. 2015

Reviews in the Neurosciences

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AbstractIntervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could play a significant role in the etiology of this disease. Besides, the interactions with environmental factors could make the role of genetic factors more complicated. Genetic variations in disc components could participate in developing degenerative disc disease through altering the normal homeostasis of discs. Gene polymorphisms in disc proteins (collagens I, II, III, IX, and XI), proteoglycans (aggrecan), cytokines (interleukins I, VI, and X), enzymes (matrix metalloproteinases II, III, and IX), and vitamin D receptor seem to play considerable roles in the pathology of this disease. There are also many other investigated genes that could somehow take part in the process. However, it seems that more studies are needed to clarify the exact role of genetics in IVDD.

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Section: Collagen IIImentioning

confidence: 92%

Section: Collagen Vmentioning

confidence: 99%

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Genetic aspects of intervertebral disc degeneration

Hanaei

Abdollahzade

Khoshnevisan

et al. 2015

Reviews in the Neurosciences

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“…It is now known that degenerative disc disease is strongly correlated to genetic factors, investigations indicating that heredity has a major role for degeneration of disc and implies approximately 74% in adult populations, as a variation. Since 1998 there were many genes associated with degenerative disc hernias declarated such as MMP-3, VDR, collagen I, collagen IX (COL9A2 and COL9A3), collagen XI (COL11A2), vitamin D receptor, IL-1, IL-6, CILP, and aggrecan (Cevei et al 2011).…”

Section: Description and Scopementioning

confidence: 99%

“…Those changes are related with disc extrusion, disc hernia, free disc fragment, problems of the posterior vertebral ligament Karabekir et al, 2010). The composition of the disc changes during development, growth, ageing and degeneration and this impress the response of the disc to changes in mechanical stress (Cevei et al 2011;Modic, 2007).…”

Section: Description and Scopementioning

confidence: 99%

Anatomical and Surgical Perspective to Approach Degenerative Disc Hernias

Karabekir¹,

Göçmen-Mas²,

Edizer³

2012

Explicative Cases of Controversial Issues in Neurosurgery

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Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation

Schwan

Ludtka

Friedmann

et al. 2017

Tissue Eng Regen Med

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Autologous disc cell transplantation (ADCT) is a cell-based therapy aiming to initiate regeneration of intervertebral disc (IVD) tissue, but little is known about potential risks. This study aims to investigate the presence of structural phenomena accompanying the transformation process after ADCT treatment in IVD disease. Structural phenomena of ADCT-treated patients (Group 1, n = 10) with recurrent disc herniation were compared to conventionally-treated patients with recurrent herniation (Group 2, n = 10) and patients with a first-time herniation (Group 3, n = 10). For ethical reasons, a control group of ADCT patients who did not have a recurrent disc herniation was not possible. Tissue samples were obtained via micro-sequestrectomy after disc herniation and analyzed by micro-computed tomography, scanning electron microscopy, energy dispersive spectroscopy, and histology in terms of calcification zones, tissue structure, cell density, cell morphology, and elemental composition. The major differentiator between sample groups was calcium microcrystal formation in all ADCT samples, not found in any of the control group samples, which may indicate disc degradation. The incorporation of mineral particles provided clear contrast between the different materials and chemical analysis of a single particle indicated the presence of magnesium-containing calcium phosphate. As IVD calcification is a primary indicator of disc degeneration, further investigation of ADCT and detailed investigations assessing each patient's Pfirrmann degeneration grade following herniation is warranted. Structural phenomena unique to ADCT herniation prompt further investigation of the therapy's mechanisms and its effect on IVD tissue. However, the impossibility of a perfect control group limits the generalizable interpretation of the results.

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Imagistic and histopathologic concordances in degenerative lesions of intervertebral disks

Cited by 6 publications

References 25 publications

Genetic aspects of intervertebral disc degeneration

Genetic aspects of intervertebral disc degeneration

Anatomical and Surgical Perspective to Approach Degenerative Disc Hernias

Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation

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