Imatinib‐associated hyperpigmentation, a side effect that should be recognized

McPherson, Tess; Шерман, В. Д.; Turner, Richard

doi:10.1111/j.1468-3083.2008.02706.x

Cited by 53 publications

(45 citation statements)

References 10 publications

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“…In one study of 118 patients with CML on imatinib, 41% of cases exhibited hypopigmentation of the skin, and only 4% of the cases showed hyperpigmentation [4]. There are other case reports showing the association between imatinib therapy and pigmentation of the hard palatal mucosa [5][6][7], nails [8], and skin [5]. Of the 8 total case reports of well-documented imatinib-associated pigmentation, all involved the mucosa of the hard palate.…”

Section: Discussionmentioning

confidence: 99%

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Mucosal Pigmentation Caused by Imatinib: Report of Three Cases

Malik²,

Blaeser³

et al. 2011

Head and Neck Pathol

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Section: Discussionmentioning

confidence: 99%

“…In five recently published articles, patients on imatinib were noted to develop cutaneous pigmentation [4,5], diffuse hyperpigmentation on the hard palate mucosa [5][6][7] or melanonychia [8].…”

Section: Introductionmentioning

confidence: 99%

Mucosal Pigmentation Caused by Imatinib: Report of Three Cases

Malik²,

Blaeser³

et al. 2011

Head and Neck Pathol

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“…Imatinib therapy can produce cutaneous and mucosal depigmentation or hyperpigmentation [72] which proved to be dose related and reversible when administration ceases. Imatinib effects c-kit, which is a tyrosine kinase receptor with regulatory action on melaninogenesis.…”

Section: Oral Hyperpigmentation-melanosismentioning

confidence: 99%

Chemotherapy: oral side effects and dental interventions. A review of the literature

Poulopoulos¹,

Papadopoulos²,

Andreadis³

2017

SDS

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Even with the evolution of chemotherapeutic procedures and agents, chemotherapy may cause certain side effects that impair the patients' quality of life. The aim of this review is to isolate and describe the oral side effects arising only from chemotherapy and focus on the dentist's contribution to their management. This paper comprises an extensive literature review of the main side effects affecting the oral health status of patients' undergoing chemotherapy procedures. In addition, it describes the dentist's contribution in the treatment of such patients before, throughout and after antineoplastic therapy. In conclusion, the oral cavity is a usual site of discomfort and pain caused by chemotherapy, making the dentist's contribution to the patient's relief imperative. Key words:Chemotherapy, oral side effects, oral mucositis, oral infections ABSTRACTArticle history:

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“…Diffuse skin and hair depigmentation associated with disappearance of lentigines has been described [34]. Conversely, hyperpigmentation and repigmentation of the skin and hair have also been reported [5,35,36]. These pigmentary changes are reversible upon treatment discontinuation and might be caused by the inhibition of ckit, which is involved in melanogenesis via the transcription factor MITF [37,38].…”

Section: Drugs Indications and Mechanisms Of Actionmentioning

confidence: 98%