Imbalance in the diurnal salivary testosterone/cortisol ratio in men with severe obstructive sleep apnea: an observational study

Ghiciuc, Cristina Mihaela; Dima-Cozma, Lucia Corina; Bercea, Raluca; Lupușoru, Cătălina Elena; Mihăescu, T; Cozma, Sebastian; Patacchioli, Francesca Romana

doi:10.1016/j.bjorl.2015.09.004

Cited by 24 publications

(23 citation statements)

References 34 publications

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“…The rate of equilibrium of cortisol between blood and saliva was very fast, being less than 5 minutes. Since only free levels of cortisol are detected in saliva, salivary cortisol is suggested to be a more appropriate measure for the clinical assessment of adrenocortical function than serum cortisol (11,18,20,25,26,37,67,70,74,76,83–85). …”

Section: Discussionmentioning

confidence: 99%

Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk

Cozma

et al. 2017

Braz J Med Biol Res

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Currently, the potential for cardiovascular (CV) stress-induced risk is primarily based on the theoretical (obvious) side effects of stress on the CV system. Salivary cortisol and α-amylase, produced respectively by the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary (SAM) system during stress response, are still not included in the routine evaluation of CV risk and require additional and definitive validation. Therefore, this article overviews studies published between 2010 and 2015, in which salivary cortisol and α-amylase were measured as stress biomarkers to examine their associations with CV/CMR (cardiometabolic risk) clinical and subclinical indicators. A comprehensive search of PubMed, Web of Science and Scopus electronic databases was performed, and 54 key articles related to the use of salivary cortisol and α-amylase as subclinical indicators of stress and CV/CMR factors, including studies that emphasized methodological biases that could influence the accuracy of study outcomes, were ultimately identified. Overall, the biological impact of stress measured by salivary cortisol and α-amylase was associated with CV/CMR factors. Results supported the use of salivary cortisol and α-amylase as potential diagnostic tools for detecting stress-induced cardiac diseases and especially to describe the mechanisms by which stress potentially contributes to the pathogenesis and outcomes of CV diseases.

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Section: Discussionmentioning

confidence: 99%

Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk

Cozma

et al. 2017

Braz J Med Biol Res

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“…In experimental ex vivo models, S. scardica showed a capacity to inhibit human serotonin transporter (hSERT) greater than in rat models [ 77 ]. Accordingly, the in vivo test in rats showed that S. scardica extract administered orally has been associated with psychostimulant and antidepressive effects, being classified as perhaps a substitute for adaptogens and thus useful for other pathologies correlated with depressive or altered mental status like sleep apnea or increased cardiovascular risks [ 87 – 89 ].…”

Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

268

143

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Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a reliable source of new therapy. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. The medicinal use of plants as analgesic or antinociceptive drugs in traditional therapy is estimated to be about 80% of the world population. The Lamiaceae family, one of the most important herbal families, incorporates a wide variety of plants with biological and medical applications. In this study, the analgesic activity, possible active compounds of Lamiaceae genus, and also the possible mechanism of actions of these plants are presented. The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.

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“…Several studies have found low serum testosterone levels in patients with OSA . The apnea‐hypopnea index (AHI) is one of the factors reported to be significantly associated with a low testosterone level among patients with severe OSA . Some studies, however, have shown that the administration of testosterone worsens the severity of OSA …”

Section: Introductionmentioning

confidence: 99%

Serum testosterone/cortisol ratio in people with obstructive sleep apnea

Mohammadi

Rezaei

Sharafkhaneh

et al. 2019

Clinical Laboratory Analysis

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Objectives Obstructive sleep apnea (OSA) is a major health problem that has been associated with endocrine dysfunction in the hypothalamic‐pituitary‐gonadal (HPG) and hypothalamic‐pituitary‐adrenal (HPA) axes. This study investigated cortisol, testosterone, and the testosterone/cortisol ratio in patients with OSA compared to normal sleepers. Methods Thirty‐nine OSA patients diagnosed by overnight polysomnography (PSG) were divided into three groups, including ten mild OSA patients, 16 patients with moderate OSA, and 13 patients with severe OSA according to the apnea‐hypopnea index (AHI). In addition, 13 normal sleepers with normal PSG findings were recruited as the control group. Serum levels of cortisol, testosterone, and sex hormone‐binding globulin (SHBG) were measured using enzyme‐linked immunosorbent assay (ELISA). Results There were no significant differences between the normal sleepers and the three subtypes of OSA in terms of total and free testosterone levels (P > .1). The results showed significantly higher levels of cortisol in the severe OSA group compared to the normal sleepers and the two other subtypes of OSA (P < .01). In addition, the testosterone/cortisol (T/C) ratio was significantly lower among the severe OSA compared to the moderate OSA patients (P = .01). A significant correlation was observed between minimal SpO2 and AHI (r=−0.69, P < .01), cortisol and AHI (r = .47, P < .01) and cortisol and minimal SpO2 (r = −.26, P = .06). Conclusion According to the findings, OSA is linked to HPA axis activity in severe OSA patients but not among the mild and moderate subtypes of the disorder.

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Imbalance in the diurnal salivary testosterone/cortisol ratio in men with severe obstructive sleep apnea: an observational study

Cited by 24 publications

References 34 publications

Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk

Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Serum testosterone/cortisol ratio in people with obstructive sleep apnea

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