Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Takeshita, Satoshi; Kawamura, Yoichi; Takabayashi, Humiyo; Yoshida, Naoki; Nonoyama, Shigeaki

doi:10.1111/j.1365-2249.2005.02714.x

Cited by 17 publications

(13 citation statements)

References 30 publications

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“…The imbalance between VEGF (a stimulator of angiogenesis) and endostatin (an inhibitor of angiogenesis) has been demonstrated in many benign conditions other than diabetic retinopathy [39,65] such as ischemic heart disease [66], rheumatoid arthritis [67], emphysema [68], Kawasaki disease [67,69], ulcerative colitis [70], and neoplastic diseases as colorectal cancer [40], renal cancer [41], pituitary adenoma [71], breast cancer [72], and both primary [73] and metastatic [74] liver tumors.…”

Section: Discussionmentioning

confidence: 99%

Lowering Homocysteine Decreases Levels and Expression of VEGF165 and Endostatin

Atta

El-Rehani

Raheim

et al. 2008

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Lowering Homocysteine Decreases Levels and Expression of VEGF165 and Endostatin

Atta

El-Rehani

Raheim

et al. 2008

Journal of Surgical Research

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“…Although there are no reports on the correlation between the endostatin and the cerebral ischemia, some studies have revealed the role of endostatin in other angiogenesis-dependent diseases such as atherosclerosis, Kawasaki disease and ischemic heart disease [22][23][24] . In addition, the serum endostatin has been reported to increase in several types of malignant tumor [25][26][27] .…”

Section: Discussionmentioning

confidence: 99%

Increased protein and mRNA expression of endostatin in the ischemic brain tissue of rabbits after middle cerebral artery occlusion

Huang

Chen

et al. 2007

Neurosci. Bull.

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Objective To explore the changes of endostatin (a strong anti-angiogenesis factor) and vascular endothelial growth factor (VEGF) in the brain tissues of rabbits following cerebral ischemia induced by middle cerebral artery occlusion (MCAO). Methods Twenty-four New Zealand white rabbits were randomly divided into 5 groups: control (n = 5), sham-operation (n = 4), 2-hour ischemia (n = 5), 24-hour ischemia (n = 5), and 48-hour ischemia (n = 5). The expression of VEGF and endostatin were measured by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry, respectively. In situ hybridization was used to characterize the expression of mRNA for the endostatin. Results Both the protein (at least 50%, P < 0.01) and mRNA (at least 70%, P < 0.05) of endostatin increased significantly in the ischemic brain tissues after MCAO compared with the control group. VEGF increased at least 270% in the brain after cerebral ischemia (P < 0.05). Conclusion Cerebral ischemia leads to an up-regulation of endostatin in the brain, which is not associated with the increase of VEGF in the brain. The increase of endostatin may serve as a deleterious mechanism for ischemic injury through blocking angiogenesis.

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“…It has been proposed that dysregulation of angiogenesis plays a role in the vasculopathy of the disease (4, 5). However, studies of the pathologic changes in the vessel wall of KD patients have been hampered by the fact that tissue samples are rare due to the low mortality rate and the inability to sample coronary arteries in living children.…”

mentioning

confidence: 99%

Disruption of vascular homeostasis in patients with Kawasaki disease: Involvement of vascular endothelial growth factor and angiopoietins

Breunis¹,

Dávila²,

Shimizu³

et al. 2011

Arthritis & Rheumatism

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Objective. In Kawasaki disease (KD), a pediatric vasculitis of medium-sized arteries, the coronary arteries are most commonly affected. Angiopoietins and vascular endothelial growth factor (VEGF) play an important role in maintaining vascular homeostasis. Recently, we identified ANGPT1 and VEGFA as susceptibility loci for KD. This study was undertaken to fine-map these associations and to gain further insight into their role in this vasculitis of unknown etiology to further the search for improved diagnostic and therapeutic options.Methods. A total of 292 single-nucleotide polymorphisms (SNPs) located in VEGF and ANGPT and their receptors were genotyped in 574 families, including 462 trios. For replication, 123 cases and 171 controls were genotyped.Results. A significant association with KD susceptibility was observed with 5 SNPs in the ANGPT1 gene (most significantly associated SNP ؉265037 C>T; P combined ‫؍‬ 2.3 ؋ 10 ؊7 ) and 2 SNPs in VEGFA (most significantly associated SNP rs3025039; P combined ‫؍‬ 2.5 ؋ 10 ؊4 ). Both ANGPT1 ؉265037 C>T and VEGFA rs3025039 are located in 3 regulatory regions at putative transcription factor binding sites. We observed significantly down-regulated transcript levels of angiopoietin 1 (Ang-1) in patients with acute KD compared to patients with convalescent KD. In patients with acute KD, high serum protein levels of VEGF and Ang-2 were observed compared to patients with convalescent KD and to both controls with and controls without fever. Immunohistochemistry demonstrated VEGF and angiopoietin expression in the coronary artery wall in autopsy tissue. Conclusion. Our data support the hypothesis that dysregulation of VEGF and angiopoietins contributes to the disruption of vascular homeostasis in KD.Kawasaki disease (KD) is a systemic vasculitis of the medium-sized arteries, predominantly affecting the coronary arteries. KD affects mainly children younger than 5 years. The clinical and laboratory features observed in KD patients suggest an infectious trigger, but none has been identified. A genetic predisposition is suggested by the difference in incidence between children of Asian ethnicity and those of Caucasian ethnicity, which is sustained in those who migrate to countries with lower incidence, and the increased incidence in siblings and parents of children with KD (1,2).In general, it is proposed that an unknown inflammatory stimulus initiates a cascade of events that

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Imbalance in the production between vascular endothelial growth factor and endostatin in Kawasaki disease

Cited by 17 publications

References 30 publications

Lowering Homocysteine Decreases Levels and Expression of VEGF165 and Endostatin

Lowering Homocysteine Decreases Levels and Expression of VEGF165 and Endostatin

Increased protein and mRNA expression of endostatin in the ischemic brain tissue of rabbits after middle cerebral artery occlusion

Disruption of vascular homeostasis in patients with Kawasaki disease: Involvement of vascular endothelial growth factor and angiopoietins

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