2009
DOI: 10.3324/haematol.2008.003103
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Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab

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Cited by 30 publications
(38 citation statements)
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“…The predominant increase of mTregs after HSCT fits with the findings of Matsuoka et al, 7 who reported a predominance of the activated/memory Treg phenotype after HSCT. Matthews et al 5 in a small series of 25 patients suggested that, beyond 3 months, the Treg numbers and their frequencies among CD4 + T cells gradually increased in patients developing chronic GVHD compared with patients without chronic GVHD. However, in our far larger series we did not find any correlation between GVHD and numbers of total Tregs, nTregs or mTregs, or their ratio to CD4 + T cells or their subsets.…”
Section: Reconstitution Of Total Naive and Memory Tregsmentioning
confidence: 99%
See 1 more Smart Citation
“…The predominant increase of mTregs after HSCT fits with the findings of Matsuoka et al, 7 who reported a predominance of the activated/memory Treg phenotype after HSCT. Matthews et al 5 in a small series of 25 patients suggested that, beyond 3 months, the Treg numbers and their frequencies among CD4 + T cells gradually increased in patients developing chronic GVHD compared with patients without chronic GVHD. However, in our far larger series we did not find any correlation between GVHD and numbers of total Tregs, nTregs or mTregs, or their ratio to CD4 + T cells or their subsets.…”
Section: Reconstitution Of Total Naive and Memory Tregsmentioning
confidence: 99%
“…2,3 Several studies correlating Treg reconstitution and GVHD suggest that an imbalance between effector T cells and Tregs within the GVHD process may be more important than the absolute numbers of circulating Tregs. [4][5][6][7] However, Tregs are a heterogeneous population. Indeed, just as for conventional T cells, naive (nTreg) and memory Treg (mTreg) subsets have already been described.…”
Section: Introductionmentioning
confidence: 99%
“…Although a variety of Treg populations that ameliorate the development of aGVHD have been described, the majority of studies have focused on CD4 + CD25 + forkhead box P3 (FoxP3 + ) Tregs, which have been shown to suppress alloreactivity in a cell contact-dependent manner both in vitro and in vivo [7][8][9][10][11]. Patients who experienced aGVHD had a lower frequency of FoxP3 + Tregs…”
Section: Introductionmentioning
confidence: 99%
“…FOXP3 þ T-cell frequencies early after pediatric HSCT showed a strong inverse correlation with the development of early allo-reactive disease, this is similar to what has been shown in adult patients. 17,19,20,29 In the first weeks following HSCT, the T-cell compartment repopulates rapidly through lymphopenia-induced expansion of mature T cells contained within the stem cell allograft. At this early stage, the thymus has a minor role in T-cell reconstitution also in children.…”
Section: Discussionmentioning
confidence: 99%
“…Clinical studies in adult patients have shown increased FOXP3 þ Treg proportions in the donor graft or FOXP3 þ Treg proportions early after HSCT to be negatively correlated with aGvHD. 5,[17][18][19][20][21] In pediatric patients, data on such a correlation are very few. 22 The aim of this single-center study is to obtain a clearer insight into the reconstitution pattern of FOXP3 þ T cells in pediatric MSD, MUD and UCB HSCT recipients, and the possible relationship to the development of early allo-reactive disease.…”
Section: Introductionmentioning
confidence: 99%