Imbalance of plasma membrane ion leak and pump relationship as a new aetiological basis of certain disease states

Ronquist, Gunnar; Waldenström, Anders

doi:10.1111/j.1365-2796.2003.01235.x

Cited by 28 publications

(18 citation statements)

References 72 publications

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“…1B, 2, 3), which indicated that other non-ROS-related processes were still of importance in Musa species. The basis for life is the ability of the cell to maintain ion gradients across biological membranes (Ronquist and Waldenström 2003), thus it is necessary to maintain membrane protein stability and function for plants in order to survive in low-temperature conditions. MDA is a harmful lipid peroxidation product and H 2 O 2 represents a highly toxic active oxygen species that can damage many important cellular components (Kuzniak and Urbanek 2000).…”

Section: Resultsmentioning

confidence: 99%

The influence of low temperature on photosynthesis and antioxidant enzymes in sensitive banana and tolerant plantain (Musa sp.) cultivars

Zhang

Zhang²,

Chow

et al. 2011

Photosynt.

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Low temperature (LT) is one of the major factors that limit crop production and reduce yield. To better understand the cold-tolerance mechanism in the plantains, a sensitive cultivar Williams (Musa acuminata AAA cv. Williams) and a tolerant cultivar Cachaco (Musa paradisiaca ABB cv. Dajiao) were used. LT resulted in increased malondialdehyde (MDA) content, elevated contents of hydrogen peroxide (H 2 O 2 ) and superoxide radical (O 2• -), and decreased photochemical efficiency (F v /F m ) and net photosynthetic rate (P N ), but cv. Cachaco showed better LT tolerance than cv. Williams. After LT treatment for 120 h, total scavenging capability (DPPH • scavenging capability) in Williams showed a significant decrease but no significant alternations was found in Cachaco. Ascorbate peroxidase (APX) and peroxidase (POD) displayed a significant increase but superoxide dismutase (SOD) showed no significant alternations and catalase (CAT) showed a significant decrease in Cachaco after 120 h of LT treatment. All the four antioxidant enzymes above showed a significant decrease in Williams after 120 h of LT treatment. Our results suggest that higher activities of APX, POD, SOD, and DPPH • scavenging capability to a certain extent can be used to explain the higher cold tolerance in the plantain, which would provide a theoretical guidance for bananas production and screening cold-resistant variety.

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Section: Resultsmentioning

confidence: 99%

The influence of low temperature on photosynthesis and antioxidant enzymes in sensitive banana and tolerant plantain (Musa sp.) cultivars

Zhang

Zhang²,

Chow

et al. 2011

Photosynt.

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“…The speciWc eVects of K + ions on behavior of zoospores from oomycetes were analyzed by addition of potassium salts or ionophores to the zoospore suspensions (Harold, 1987;Ronquist and Waldenstrom, 2003). Addition of 5, 10 mM KCl and 10 mM K 2 SO 4 caused a signiWcant reduction in swimming speed and a change in swimming pattern of Ph.…”

Section: Discussionmentioning

confidence: 99%

Potassium homeostasis influences the locomotion and encystment of zoospores of plant pathogenic oomycetes

Appiah¹,

West²,

Osborne³

et al. 2005

Fungal Genetics and Biology

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Zoospores of plant pathogenic oomycetes exhibit distinct swimming speeds and patterns under natural conditions. Zoospore swimming is influenced by ion homeostasis and changes in the ionic composition of media. Therefore, we used video microscopy to investigate swimming patterns of five oomycete species in response to changes in potassium homeostasis. In general, zoospore speed tended to be negatively correlated with zoospore size. Three Phytophthora species (Phytophthora palmivora, Phytophthora megakarya, and Phytophthora infestans) swam in straight patterns with speeds ranging from 50 to 250 microm/s whereas two Pythium species (Pythium aphanidermatum and Pythium dissotocum) swam at similar speeds ranging from 180 to 225 microm/s with a pronounced helical trajectory and varying amplitudes. High external concentrations of potassium salts reduced the swimming speed of Ph. palmivora and induced encystment. This was not observed for Py. aphanidermatum. Application of the potassium ionophores gramicidin, nigericin and valinomycin resulted in reduced swimming speeds and changes in the swimming patterns of the Phytophthora species. Therefore, potassium ions play a key role in regulating zoospore behavior.

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“…It is also essential in the signaling processes associated with coordinated movements of cells and organisms and is the basis of cognitive processes. In contrast, deregulated ionic imbalances are associated with pathological consequences, since ionic disturbances occur during apoptosis, ischemia and several channelopathies (Ronquist & Waldenstrom, 2003).…”

Section: Ionic Homeostasis and Generation Of Plasma Membrane Potentiamentioning

confidence: 99%

Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis

2006

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Apoptosis is characterized by the programmed activation of specific biochemical pathways leading to the organized demise of cells. To date, aspects of the intracellular signaling machinery involved in this phenomenon have been extensively dissected and characterized. However, recent studies have elucidated a novel role for changes in the intracellular milieu of the cells as important modulators of the cell death program. Specially, intracellular ionic homeostasis has been reported to be a determinant in both the activation and progression of the apoptotic cascade. Several apoptotic insults trigger specific changes in ionic gradients across the plasma membrane leading to depolarization of the plasma membrane potential (PMP). These changes lead to ionic imbalance early during apoptosis. Several studies have also suggested the activation and/or modulation of specific ionic transport mechanisms including ion channels, transporters and ATPases, as mediators of altered intracellular ionic homeostasis leading to PMP depolarization during apoptosis. However, the role of PMP depolarization and of the changes in ionic homeostasis during the progression of apoptosis are still unclear. This review summarizes the current knowledge regarding the causes and consequences of PMP depolarization during apoptosis. We also review the potential electrogenic ion transport mechanisms associated with this event, including the net influx/efflux of cations and anions. An understanding of these mechamisms could lead to the generation of new therapeutic approaches for a variety of diseases involving apoptosis.

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Imbalance of plasma membrane ion leak and pump relationship as a new aetiological basis of certain disease states

Abstract: Abstract. Ronquist G, Waldenström A (University Hospital, Uppsala; and University Hospital, Umeå; Sweden). Imbalance of plasma membrane ion leak and pump relationship as a new aetiological basis of certain disease states (Review).

Cited by 28 publications

References 72 publications

The influence of low temperature on photosynthesis and antioxidant enzymes in sensitive banana and tolerant plantain (Musa sp.) cultivars

The influence of low temperature on photosynthesis and antioxidant enzymes in sensitive banana and tolerant plantain (Musa sp.) cultivars

Potassium homeostasis influences the locomotion and encystment of zoospores of plant pathogenic oomycetes

Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis

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