Imbalance of tissue inhibitors of metalloproteinases (TIMP) – 1 and – 4 serum levels, in patients with inflammatory bowel disease

Kapsoritakis, Andreas; Kapsoritaki, Anastasia I; Davidi, Ioanna P; Lotis, Vasilios D; Manolakis, Anastassios C.; Mylonis, Petros I; Theodoridou, Aikaterini; Germenis, Anastasios E.; Potamianos, Spyros

doi:10.1186/1471-230x-8-55

Cited by 40 publications

(34 citation statements)

References 19 publications

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“…Our results suggest that not only MMP-9 but also TIMP-1 could be a useful additional biomarker in IBD. Taken together, our data, which are consistent with others, suggest that the imbalance between MMPs and TIMPs can determine the degree of mucosal damage in IBD [44,45,46,47,48,49]. …”

Section: Discussionsupporting

confidence: 79%

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The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

Lakatos

Hritz

Varga

et al. 2012

Dig Dis

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Background: It has been suggested that matrix metalloproteinases (MMPs) may play a role in the pathogenesis of inflammatory bowel diseases (IBD). However, the impact of serum MMPs and their inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] have scarcely been investigated in the same experimental setting in ulcerative colitis (UC) and Crohn’s disease (CD) as well as their correlation with IBD activity. Methods: MMP-2, MMP-7, MMP-9, TIMP-1 and TIMP-2 serum antigen levels were determined in 23 patients with UC, 25 patients with CD and 10 healthy control patients by enzyme-linked immunoassay technique. Statistical analysis with one-way ANOVA and Student’s t tests was performed. A linear regression analysis or a Spearman’s r test was used to assess correlation. Differences were considered significant with p < 0.05. Results: Serum antigen concentrations of MMP-9, TIMP-1 and TIMP-2 were significantly higher in UC and CD patients compared to controls. MMP-7 was also significantly higher in CD compared with controls. Elevated MMP-9 and TIMP-1 antigen levels showed significant positive correlation with disease activity of IBD. MMP-2 and TIMP-2 levels inversely correlated with CD activity. Significant correlations were found between MMP-9/TIMP-1 and MMP-2/TIMP-2 antigen levels in both UC and CD. Conclusions: We demonstrated that serum antigen concentrations of MMP-9, TIMP-1 and TIMP-2 were significantly increased in patients with UC and CD compared to controls. Our results suggest that MMPs and TIMPs may contribute to the inflammatory and remodeling processes in IBD. Serum MMP-9 and TIMP-1 might be useful as additional biomarkers in the assessment of IBD activity.

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Section: Discussionsupporting

confidence: 79%

“…In the inflamed mucosa of patient with IBD, TIMP expression inversely correlates with the production of proinflammatory cytokines and with the grade of inflammation. The sensitive balance between MMPs and TIMPs is essential for many physiological processes of the gut [44,45,46,47,48,49]. …”

Section: Introductionmentioning

confidence: 99%

The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

Lakatos

Hritz

Varga

et al. 2012

Dig Dis

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“…The authors claim that validation of the obtained results may provide a greater understanding of colon cancer liver metastasis [76]. Nevertheless, the perturbation of the TIMP-1 level is common for most inflammatory diseases and as inflammatory factors play a major role in mediating tumourigenesis, its fluctuating level does not seem to be a unique marker for liver metastasis [77][78][79][80]. On the other hand, monitoring the level of TIMP-1 can be a useful tool for monitoring disease progression.…”

Section: Cancer Cell-hepatocyte Interaction In Cancer Progressionmentioning

confidence: 94%

The role of the cell–cell interactions in cancer progression

Kamińska¹,

Szczylik²,

Bielecka

et al. 2015

J Cellular Molecular Medi

102

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In the field of cancer research, scientific investigations are based on analysing differences in the secretome, the proteome, the transcriptome, the expression of cell surface molecules, and the deregulation of signal transduction pathways between neoplastic and normal cells. Accumulating evidence indicates a crucial role in carcinogenesis concerning not only stromal cells but also normal cells from target organs and tissue where tumours emerge. The tumour microenvironment (TME) definitively plays an important role in regulating neighbouring cell behaviour. To date, limited attention has been focused upon interactions between cancer cells and normal cells. This review concentrates on the interactions between stromal and healthy cells from the TME in cancer development. In the article, the authors also describe mutations, genes and proteins expression pattern that are involved in tumour development in target organ.

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“…Several MMPs have been reported to be increased in the gut mucosa of patients with IBD [7][8][9][10][11][12][13][14]. Thus, we hypothesize that genetically encoded variation between individuals in MMP production may therefore contribute to disease onset, type or severity.…”

Section: Introductionmentioning

confidence: 89%

Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis

et al. 2011

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Imbalance of tissue inhibitors of metalloproteinases (TIMP) – 1 and – 4 serum levels, in patients with inflammatory bowel disease

Cited by 40 publications

References 19 publications

The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

The role of the cell–cell interactions in cancer progression

Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis

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