Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma

Wang, Kai; Zhang, Min; Qian, Yingying; Ding, Zheyuan; Lv, Junhui; Shen, Huahao

doi:10.1631/jzus.b1100165

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…In fact, a progressive reduction in the expression of DUSP1 was observed as the disease progressed from normal through FIGO stages I–III. Gradual decrease in the expression of the gene has been shown in lung cancer as the tissue type went from normal to increasingly undifferentiated carcinoma [ 46 ]. Conversely, a role of DUSP1 in angiogenesis, invasion and metastasis in non-small-cell lung cancer (NSCLC) cells has also been demonstrated by Moncho-Amor et al [ 47 ] by downregulation of DUSP1 in H460 cell line.…”

Section: Discussionmentioning

confidence: 99%

Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease

et al. 2013

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Cervical cancer is the second most common cancer among women worldwide, with developing countries accounting for >80% of the disease burden. Although in the West, active screening has been instrumental in reducing the incidence of cervical cancer, disease management is hampered due to lack of biomarkers for disease progression and defined therapeutic targets. Here we carried out gene expression profiling of 29 cervical cancer tissues from Indian women, spanning International Federation of Gynaecology and Obstetrics (FIGO) stages of the disease from early lesion (IA and IIA) to progressive stages (IIB and IIIA–B), and identified distinct gene expression signatures. Overall, metabolic pathways, pathways in cancer and signaling pathways were found to be significantly upregulated, while focal adhesion, cytokine–cytokine receptor interaction and WNT signaling were downregulated. Additionally, we identified candidate biomarkers of disease progression such as SPP1, proliferating cell nuclear antigen (PCNA), STK17A, and DUSP1 among others that were validated by quantitative real-time polymerase chain reaction (qRT-PCR) in the samples used for microarray studies as well in an independent set of 34 additional samples. Integrative analysis of our results with other cervical cancer profiling studies could facilitate the development of multiplex diagnostic markers of cervical cancer progression.

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Section: Discussionmentioning

confidence: 99%

Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease

et al. 2013

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“…The primers used in this study were for human EGFR forward primer: 5 0 -TTTGCTGATTCAGGCTTGG-3 0 ; reverse primer: 5 0 -AGAAAACTGACCATGTTGCTTG-3 0 (Toby et al, 2010) for human cyclin D1 forward: 5 0 -CCGTCCATGCGGAAGATC-3 0 ; reverse 5 0 -GA AGACCTCCTCCTCGCACT-3 0 (Medeiros et al, 2002), for ERK1/2. forward: 5 0 -CCATTGGGTTGTGGAGGCAATG-3 0 , reverse: 5 0 -CACTC TGGGGATCAGTAAGGAC-3 0 (Wang et al, 2011).…”

Section: Rna Extraction and Reverse-transcriptase Pcrmentioning

confidence: 99%

Cellular Intrinsic Factors Involved in the Resistance of Squamous Cell Carcinoma to Photodynamic Therapy

Gilaberte¹,

Milla

Salazar

et al. 2014

Journal of Investigative Dermatology

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Photodynamic therapy (PDT) is widely used to treat non-melanoma skin cancer. However, some patients affected with squamous cell carcinoma (SCC) do not respond adequately to PDT with methyl-δ-aminolevulinic acid (MAL-PDT) and the tumors acquire an infiltrative phenotype and became histologically more aggressive, less differentiated, and more fibroblastic. To search for potential factors implicated in SCC resistance to PDT, we have used the SCC-13 cell line (parental) and resistant SCC-13 cells obtained by repeated MAL-PDT treatments (5th and 10th PDT-resistant generations). Xenografts assays in immunodeficient mice showed that the tumors generated by resistant cells were bigger than those induced by parental cells. Comparative genomic hybridization array (aCGH) showed that the three cell types presented amplicons in 3p12.1 CADM2, 7p11.2 EFGR, and 11q13.3 CCND1 genes. The 5th and 10th PDT-resistant cells showed an amplicon in 5q11.2 MAP3K1, which was not present in parental cells. The changes detected by aCGH on CCND1, EFGR, and MAP3K1 were confirmed in extracts of SCC-13 cells by reverse-transcriptase PCR and by western blot, and by immunohistochemistry in human biopsies from persistent tumors after MAL-PDT. Our data suggest that genomic imbalances related to CCND1, EFGR, and particularly MAP3K1 seem to be involved in the development of the resistance of SCC to PDT.

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“…It has been reported that DUSP1/MKP1 can regulate MAPKs activity with an important role in tumor biology (Moncho-Amor et al, 2011). In addition, DUSP1 level has been found to be decreased in lung squamous carcinoma with cancer progression (Wang et al, 2011). However, the role of DUSP1 is still incompletely understood in the SCCP.…”

Section: Introductionmentioning

confidence: 99%

DUSP1 is involved in the progression of small cell carcinoma of the prostate

Zhang

Chen

et al. 2018

Saudi Journal of Biological Sciences

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Small cell carcinoma of the prostate (SCCP) is a rare and the most aggressive variant of prostate cancer. There is no effective cure or treatment for SCCP. Therefore, there is an urgent need for new therapy to improve the prognosis of patients with SCCP. DUSP1 is a dual specific phosphatase with an increasingly recognized in tumor biology. Altered expression of DUSP1 induced changes in the expression of genes involved in various biological pathways, including cell-cell signaling and angiogenesis. To understand more about the role of DUSP1 in SCCP, we evaluated the biological function and associated regulatory mechanism of DUSP1. In this study, DUSP1 was significantly down-regulated in human SCCP compared with the non-carcinoma tissues (P < 0.05). Overexpression of DUSP1 was found to suppress MAPK signaling and cell proliferation in PC-3 cells. Additionally, silencing of DUSP1 enhanced MAPK signaling and PC-3 cell proliferation. Moreover, it was observed that DUSP1 blocked the phosphorylation of p38 MAPK induced by anisomycin. Taken together, this investigation suggests that DUSP1 is involved in the progression of SCCP and may provide a new therapeutic target for SCCP treatment.

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Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma

Cited by 5 publications

References 32 publications

Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease

Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease

Cellular Intrinsic Factors Involved in the Resistance of Squamous Cell Carcinoma to Photodynamic Therapy

DUSP1 is involved in the progression of small cell carcinoma of the prostate

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