Imidacloprid disrupts the endocrine system by interacting with androgen receptor in male mice

Yuan, Xianling; Shen, Jiayan; Zhang, Xinyue; Tu, Wenqing; Fu, Zhengwei; Jin, Yuanxiang

doi:10.1016/j.scitotenv.2019.135163

Cited by 35 publications

(25 citation statements)

References 58 publications

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“…Our results of the H&E staining of the testes revealed a reduction in spermatogenesis in F1-8w male mice and marginal condensation of the chromatin in the round spermatids in F1-24w male mice. This proved that According to the previous studies [23,58], this type of changes usually occurred if the weight of the testes remained constant or decreased after the exposure. However, the weight of the testes in F1-8w male mice after maternal OBS-H treatment was increased in our study.…”

Section: Discussionsupporting

confidence: 77%

“…Additionally, the expression of the genes of cholesterol synthesis (HMG-CoA reductase and HMG-CoA synthase) was significantly stimulated in the F0 generation. Cholesterol enters the cell and is transported through the mitochondrial membrane by STAR-and PBR-dependent transport that regulates cholesterol participation in the synthesis of steroid hormones [23,50,52,53]. The mRNA levels of the key genes involved in cholesterol transport and testosterone synthesis, including 3β-HSD, 17β-HSD, P450-SCC, and P450 17α, are also important [32,54].…”

Section: Discussionmentioning

confidence: 99%

“…Many environmental chemicals disrupt the animal endocrine system [16][17][18][19][20]. These chemicals interfere with the endocrine system by various routes involved in steroid receptor binding (agonists), blockade of steroid receptor binding (antagonists), or disruption of steroid biosynthesis [21][22][23]. Recently, some PFCs have been identified as endocrine disruptors in animals [24].…”

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confidence: 99%

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Maternal exposure of mice to sodium <i>p</i>-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring

Wang

Jin

et al. 2021

Endocr J

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The toxicity of certain novel perfluoroalkyl substances (PFCs) has attracted increasing attention. However, the toxic effects of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) on the endocrine system have not been elucidated. In this study, OBS was added to the drinking water during the pregnancy and lactation of the healthy female mice at dietary levels of 0.0 mg/L (CON), 0.5 mg/L (OBS-L), and 5.0 mg/L (OBS-H). OBS exposure during the pregnancy and lactation resulted in the presence of OBS residues in the placenta and fetus. We also analyzed physiological and biochemical parameters and gene expression levels in mice of the F0 and F1 generations after maternal OBS exposure. The total serum cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were significantly increased in female mice of the F0 generation. The androgen levels in the serum and the ovarian mRNA levels of androgen receptor (AR) also tended to increase after maternal OBS exposure in the F0 generation mice. Moreover, maternal OBS exposure altered the mRNA expression of endocrine-related genes in male mice of F1 generation. Notably, the serum TC and LDL-C levels were significantly increased in 8-weeks-old male mice of the F1 generation, and the serum high-density lipoprotein cholesterol (HDL-C) levels were decreased in 24-week-old male mice of the F1 generation. These results indicated that maternal OBS exposure can interfere with endocrine homeostasis in the F0 and F1 generations. Therefore, exposure to OBS during pregnancy and lactation has the potential toxic effects on the dams and male offspring, which cannot be overlooked.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Maternal exposure of mice to sodium <i>p</i>-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring

Wang

Jin

et al. 2021

Endocr J

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“…Both AR and ER are potentially involved in mediating the action of sex steroid hormones [ 49 , 50 ]. An animal study on male mice showed IMI decreases testosterone, can interact with AR and decrease AR expression in the testes [ 51 ]. A study of endocrine activities of THX and ACE found in waste water effluent using yeast-based bioassays showed weak antagonist androgen activity and antagonist estrogen activity for THI [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Suwannarin

Prapamontol

Isobe

et al. 2021

IJERPH

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Several studies indicated organophosphate (OP) and neonicotinoid (NEO) insecticides are endocrine disruptors; however, data are scarce. This cross-sectional study recruited 143 male farmworkers aged 18–40 years in Fang district, Chiang Mai province, northern Thailand. OP exposure was assessed by measuring urinary dialkylphosphate (DAPs) using a gas-chromatography flame photometric detector. Urinary NEOs, their metabolites (NEO/m) and serum steroid hormones were measured using liquid chromatography–tandem mass spectrometry. Characteristics of participants were determined by face-to-face interviews. DAPs and five NEO/m were detected in more than 60% of samples. The concentration of diethylphosphate was highest among DAP metabolites (geometric mean concentration (GM: 23.9 ng/mL) and the concentration of imidacloprid (IMI) was highest among NEO/m (GM: 17.4 ng/mL). Linear regression models showed that the IMI level was positively associated with testosterone, dehydrocorticosterone (DHC) and dehydroepiandrosterone (DHEA) levels. Imidacloprid-olefin and DHEA levels were positively associated. Thiamethoxam (THX) were inversely associated with DHC and deoxycorticosterone levels. Clothianidin (CLO), THX and N-desmethyl-acetamiprid levels were positively associated with the androstenedione level. CLO and THX levels were inversely associated with the cortisone level. In conclusion, the association between NEO insecticides exposure and adrenal androgens, glucocorticoids and mineralocorticoids, suggest potential steroidogenesis activities. Our findings warrant further investigation.

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“…Inter alia, [37] imidaclopridi sareproductive toxicanti nm ice. [38] It causes endocrine disruptionb yi nteracting with the androgen receptor, [39] thus making us believe it is ac ompound of concern in the rapidly declining sperm counts in Western Man. [40] Yamamoto et al have been studying Lake Shinji on the northern coast of southwestern Honshu since at least the early 1980s.…”

Section: Discussionmentioning

confidence: 99%

Zero‐Order Catalysis in TAML‐Catalyzed Oxidation of Imidacloprid, a Neonicotinoid Pesticide

Warner

Somasundar

Weng

et al. 2020

Chemistry A European J

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Bis‐sulfonamide bis‐amide TAML activator [Fe{4‐NO2C6H3‐1,2‐(NCOCMe2NSO2)2CHMe}]− (2) catalyzes oxidative degradation of the oxidation‐resistant neonicotinoid insecticide, imidacloprid (IMI), by H2O2 at pH 7 and 25 °C, whereas the tetrakis‐amide TAML [Fe{4‐NO2C6H3‐1,2‐(NCOCMe2NCO)2CF2}]− (1), previously regarded as the most catalytically active TAML, is inactive under the same conditions. At ultra‐low concentrations of both imidacloprid and 2, 62 % of the insecticide was oxidized in 2 h, at which time the catalyst is inactivated; oxidation resumes on addition of a succeeding aliquot of 2. Acetate and oxamate were detected by ion chromatography, suggesting deep oxidation of imidacloprid. Explored at concentrations [2]≥[IMI], the reaction kinetics revealed unusually low kinetic order in 2 (0.164±0.006), which is observed alongside the first order in imidacloprid and an ascending hyperbolic dependence in [H2O2]. Actual independence of the reaction rate on the catalyst concentration is accounted for in terms of a reversible noncovalent binding between a substrate and a catalyst, which usually results in substrate inhibition when [catalyst]≪[substrate] but explains the zero order in the catalyst when [2]>[IMI]. A plausible mechanism of the TAML‐catalyzed oxidations of imidacloprid is briefly discussed. Similar zero‐order catalysis is presented for the oxidation of 3‐methyl‐4‐nitrophenol by H2O2, catalyzed by the TAML analogue of 1 without a NO2‐group in the aromatic ring.

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Imidacloprid disrupts the endocrine system by interacting with androgen receptor in male mice

Cited by 35 publications

References 58 publications

Maternal exposure of mice to sodium <i>p</i>-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring

Maternal exposure of mice to sodium <i>p</i>-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring

Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Zero‐Order Catalysis in TAML‐Catalyzed Oxidation of Imidacloprid, a Neonicotinoid Pesticide

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