Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice

Yang, Guiling; Yuan, Xianling; Jin, Cuiyuan; Wang, Dou; Wang, Yanhua; Miao, Wenyu; Jin, Yuanxiang

doi:10.1016/j.envpol.2020.115290

Cited by 47 publications

(23 citation statements)

References 65 publications

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“…Several studies suggested that long-term exposure can lead to impairment of the gut microbial in bees with a reduced abundance of total bacterial flora, mainly Firmicutes [ 82 , 83 , 84 , 85 , 86 ]. In pregnant mice, nitenpyram also altered lipid metabolism and decreased the abundance of Proteobacteria , specifically of the Desulfovibrionaceae family [ 87 ], and IMI was shown to reduce liver weights and alter the histological structure of hepatic tissue, disrupting the gut microbial composition with consequently impaired barrier function [ 88 ]. Hong et al evaluated the effects of IMI in crab, ‘ Erocheir sinensis ’.…”

Section: Insecticidesmentioning

confidence: 99%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides’ toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host–microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.

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Section: Insecticidesmentioning

confidence: 99%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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“…Besides, with the potential to alter microbial communities, neonicotinoid insecticides such as imidacloprid and thiamethoxam, both found in our samples, have been reported to affect not only insect microbiota (Daisley et al, 2017; Jones et al, 2017) but also the soil microbiome (Mahapatra et al, 2017) and mammal gut microbiota (Yang et al, 2020).…”

Section: Resultsmentioning

confidence: 69%

Identification of pesticides in water samples by solid‐phase extraction and liquid chromatography–electrospray ionization mass spectrometry

Lovison

Jank

Souza

et al. 2021

Water Environment Research

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The Contaminants of Emerging Concern (CECs), including pesticides, have been a trending topic and Brazil is the country with the highest usage of pesticides worldwide. This study aimed to measure the presence of pesticide residues in the water from different sources in the city of Porto Alegre. We analyzed 55 samples from drinking water treatment plants, public water sites, and sewage treatment plants from winter 2018 to summer 2020 by solid‐phase extraction and high‐performance liquid chromatography–electrospray ionization mass spectrometry. Among 184 pesticides evaluated, 107 matched validation criteria (linearity, trueness, accuracy, repeatability, reproducibility) and 15 of them were detected in different water samples, including seven insecticides, five antifungals, and three herbicides, with a wide range of toxicity levels and noticeable seasonal differences. For the worst‐case scenario evaluation, 20 out of 22 (90.9%) samples exceeded the Risk Quotient of 1. The sum of pesticide concentrations exceeded 100 ng L−1 in 66.7% of samples in February 19 and in 75% of samples in February 20 and the total pesticide concentration has reached the worrisome mark of 1615 and 954.96 ng L−1 respectively. Therefore, our results make evident the need to promote public policies to achieve better water quality monitoring. Practitioner Points Among 184 pesticides evaluated, 107 matched validation criteria (linearity, trueness, accuracy, repeatability, reproducibility). A total of 55 different water samples were analyzed, and 15 pesticides were detected and five quantified. For the worst‐case scenario evaluation, 20 out of 21 samples exceeded the Risk Quotient of 1 on Feb/20. The pesticide concentrations sum exceeded 100 ng L−1 in 66.7% of samples on February 19 and in 75% of samples on February 20. It is mandatory to improve water monitoring to guide the development of public policies concerning its quality.

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“…This process requires the presence of the intestinal microbiota, which is related to the stress response and can be affected even by pesticides (Gao et al 2018). Previous studies have shown that imidacloprid is capable of inducing microbiota dysbiosis in crabs (Hong et al 2020) and mice (Yang et al 2020). According to Yang et al (2020), the reduction of the intestinal barrier weakens the organ to toxic substances.…”

Section: Discussionmentioning

confidence: 99%

Toxicity and Genotoxicity of Imidacloprid in Tadpoles of Leptodactylus Latrans and Physalaemus Cuvieri (Anura: Leptodactylidae)

Cg¹,

Fa²,

Cf³

et al. 2021

Preprint

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Imidacloprid is a neonicotinoid insecticide widely used worldwide, but which can cause adverse effects on non-target organisms, especially in aquatic environments. This study aimed to evaluate the chronic toxicity of an insecticide-based imidacloprid in amphibians, using Leptodactylus latrans and Physalaemus cuvieri tadpoles. The parameters of survival, swimming activity, body size, damage to body structures and genotoxicity for both species were analyzed; and the ecological risk of this insecticide calculated. Chronic short-term assay was carried out for 168 h (7 days) and five concentrations of imidacloprid, between 3 and 300 µg L-1, were tested. The insecticide did not affect the tadpoles survival tadpoles; however, both species tested showed smaller body size, damage to the mouth and intestine and the induction of micronuclei and other erythrocytes nuclear abnormalities after exposure to imidacloprid-based herbicide. Insecticide exposure affected the swimming activity in L. latrans, which contributes to the greater sensitivity of L. latrans to imidacloprid when compared to P. cuvieri. All parameters analyzed indicated that the insecticide presents an ecological risk for both species at concentrations greater than 3 µg L-1. This demonstrates the genotoxicity of the insecticide imadacloprid, which can contribute to the population decline of L. latrans and P. cuvieri species in natural systems.

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Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice

Cited by 47 publications

References 65 publications

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Identification of pesticides in water samples by solid‐phase extraction and liquid chromatography–electrospray ionization mass spectrometry

Toxicity and Genotoxicity of Imidacloprid in Tadpoles of Leptodactylus Latrans and Physalaemus Cuvieri (Anura: Leptodactylidae)

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