Imidacloprid induced histological and biochemical alterations in liver of female albino rats

Toor, Harmandeep Kaur; Sangha, Gurinder Kaur; Khera, Kuldeep Singh

doi:10.1016/j.pestbp.2012.10.001

Cited by 75 publications

(29 citation statements)

References 23 publications

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“…Supporting these findings [22,25,32,33] reported a marked elevation in AST, ALT and ALP of IMI treated rats. Results are also in accordance with those of Balani et al [34] in a study of male White Leghorn (WLH) chicks treated with different concentration of IMI.…”

Section: Discussionsupporting

confidence: 58%

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Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Chakroun¹,

Grissa²,

Ezzi³

et al. 2017

JCLM

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Section: Discussionsupporting

confidence: 58%

“…Toor et al [25] demonstrated similar histological changes, by reporting leucocyte infiltration, dilatation of central vein and blood sinusoids that were observed in hepatic tissue of female rats exposed to IMI at 45 mg/kg/body weight for four weeks.…”

Section: Discussionmentioning

confidence: 62%

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Chakroun¹,

Grissa²,

Ezzi³

et al. 2017

JCLM

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“…Also, Bhardwaj et al (2010) reported increased activity of serum AST and ALT after orallyadministering rats with 20 mg kgG 1 dayG 1 for 90 days. Also, imidacloprid at 1/50th of LD 50 dose did not cause any histopathological changes in liver but it significantly increase the AST, ALT and ALP in the treated rats for 30 days (Toor et al, 2013). One oral dose of imidacloprid equal to 20 mg kgG 1 b.wt.…”

Section: Discussionmentioning

confidence: 87%

“…All tested doses significantly decreased the activity of LDH in the serum of treated rats compared to the control. Toor et al (2013) reported no cardiac toxicity of imidacloprid at 1/10th of the LD 50 oral dose in rats for 30 days.…”

Section: Adverse Effects On Cardiac Functionmentioning

confidence: 96%

Mammalian Detrimental Effects of Imidacloprid Residues in Tomato Fruits

Nassar¹,

Abbassy²,

Salem³

2015

Research J. of Environmental Toxicology

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Imidacloprid, a neonicotinoid pesticide, was used extensively to control whitefly (Bemisia tabaci) on tomato crop worldwide. Current study aimed to determine residue amounts of imidacloprid in tomato fruits after different time intervals of application and to evaluate their detrimental effects on white albino rats. Results revealed that the initial deposit (residue amount after 1 h of last spray application) was 0.316 mg kgG . Current study highlighted that there was no residual toxicity of imidacloprid after 14 days of last application.

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“…There is dearth of reports on the acute toxicity of IMD on MN, CA and hematological parameters in mice of either sex. Toxic effects of IMD on physiological and histological parameters have been reported in model animals like mice (Badgujar et al, 2013;Kumar et al, 2014), rat (Kandil et al, 2006;Toor et al, 2013;Vohra et al, 2014) and…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic and hematological alterations induced by acute oral exposure of imidacloprid in female mice

Kataria

Chhillar

Kumar

et al. 2015

Drug and Chemical Toxicology

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Imidacloprid (IMD), 1(6-chloro-3-pyridinyl)methyl)-N-nitro-2-imidazolidinimine, was administered in female mice to study in vivo cytogenetic (chromosomal aberrations (CAs) and micronucleus assay) and hematological effects. The acute oral LD50 was determined to be 150 mg/kg bw in mice following OECD guidelines using AOT StatPgm425 software. The mice were administered orally with distilled water (negative control); mitomycin C (MMC), 1 mg/kg (positive control) and sub-lethal doses of 37.5 (low), 75.0 (medium) and 112.5 (high) mg/kg bw (25%, 50% and 75% of LD50) of IMD to analyze CAs and hematological effects after 24 h, whereas micronucleus test (MT) after 48 h. The genotoxicity analysis revealed that selected test doses of IMD--medium and high doses--induced significantly mitotic inhibition (p < 0.01), CAs (p < 0.01) and at high dose micronucleus (MN) formation (p < 0.05). Significant changes in red blood cell (RBC; p < 0.01), hemoglobin (Hb; p < 0.01) and erythrocyte sedimentation rate (ESR; p < 0.001) were observed, except WBC in which significant increase (p < 0.001) was observed. Present observation substantiates overall significant dose dependent genotoxic potential (p < 0.05; r = 0.98) of IMD. Precautions should be taken to minimize possible risk to exposed farmers of the state of Haryana (India)--an agrarian economy.

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Imidacloprid induced histological and biochemical alterations in liver of female albino rats

Cited by 75 publications

References 23 publications

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Mammalian Detrimental Effects of Imidacloprid Residues in Tomato Fruits

Cytogenetic and hematological alterations induced by acute oral exposure of imidacloprid in female mice

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