Imidafenacin for treatment of overactive bladder and urgent urinary incontinence: the results of open-label multicenter randomized controlled  clinical trial

Al-Shukri, Salman Hasunovich; Pushkar, Dmitry; Аполихин, О.И.; Евдокимов, М. С.; Kogan, M. I.; Кривобородов, Г Г; Kagan, O F; Петров, С. Б.; Poltoratskyi, A N; Kuzmin, Igor V.; Sharvadze, G. G.

doi:10.18565/urology.2018.6.20-25

Cited by 2 publications

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“…Lesion localization was associated with recurrence (p = 0.008) [28]. The effectiveness of using this scale has been confirmed in a number of other studies on the effectiveness of surgical interventions and the use of drugs for urethral strictures [29][30][31].…”

Section: Discussionmentioning

confidence: 59%

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Prevention of Postoperative Urethral Strictures by Irrigation with 5-Fluorouracil via a Modified Urinary Catheter

Kairambayev,

Bulegenov,

Omarov

et al. 2024

Medicina

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Background and Objectives: Urethral strictures are the most common complications after surgical treatments of benign prostatic hyperplasia (BPH). Despite various preventive measures, the search for medications with antiproliferative activity and the development of surgical procedures to prevent the development of urethral strictures are still relevant. We evaluated the preventive efficacy of 5-fluorouracil against urethral strictures in patients undergoing surgery for BPH. Materials and Methods: A non-randomized clinical trial including 246 male patients with an average age of 70.0 ± 8.0 years was conducted. The main study group included 124 patients who, in addition to the standard treatment, received lavage with a 5-fluorouracil solution (1000 mg/20 mL per 500 mL of 0.9% isotonic saline) using a modified three-way urethral catheter. The monitoring of clinical, laboratory, and instrumental parameters was carried out 10 days, 3 months, and 6 months after surgery. Results: The evaluation of severity for dysuria symptoms in patients using the IPSS scale throughout the entire follow-up period showed a statistically significant decrease in ischuria and stranguria, prolongation of the interval between urinations, a decrease in intermittent urination, urinary incontinence, and straining before urination in the main group in comparison with the control patients. The patients of both study groups noted an improvement in the quality of life. It was found statistically significant decrease in the maximum urinary flow rate in the main group (p < 0.001). In the control group, after three months, four cases of urethral strictures and stenosis were recorded; after six months, this rate reached nine cases (7.3%), while in the main group, only one patient with infravesical obstruction was found (0.8%) (χ2 = 3.855, p < 0.05). Conclusions: The results of our study could indicate the effectiveness of the antiproliferative drug 5-fluorouracil in combination with use of a modified catheter in relation to the development of postoperative urethral strictures.

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Section: Discussionmentioning

confidence: 59%

“…It has been established that urinary disorders in the long-term period after surgical treatment of BPH occur in 10-35% of patients [31,32]. The clinical manifestations of such disorders are increased urination, urge to urinate, difficulty urinating, and urinary incontinence [33].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Postoperative Urethral Strictures by Irrigation with 5-Fluorouracil via a Modified Urinary Catheter

Kairambayev,

Bulegenov,

Omarov

et al. 2024

Medicina

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Assessment of Efficiency of Combined Pharmacotherapy for Imperative and Mixed Urinary Disorders in Women With the Interval Scale

Данилов

Елисеева

Danilov

et al. 2021

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Introduction. The search for effective drug combinations for treating continental disorders in women is still relevant. The interval scale for assessing lower urinary tract symptoms in women is a simple and convenient tool for monitoring pharmacotherapy. Objective: to evaluate the effectiveness of treatment of imperative and mixed urination disorders in women with alpha1-blockers in combination with nootropic drugs using an interval symptom rating scale.Materials and methods. Under observation there were 31 patients aged 40 to 73 years who applied to the Center “Urination Pathology” with mixed and imperative disorders of the continent and urinary incontinence. Conservative therapy was carried out with the appointment of alpha1-adrenoblockers, nootropic and metabolic drugs for an average of 5.8 months. The therapeutic effect is recorded using the interval symptom score scale.Results. After discontinuation of drugs, the overall score on the symptom rating scale decreased by 40.2%, imperative symptoms – by 29.5-50%, and quality of life increased by 19%. In the group of women aged 40-49, with comparable dynamics of symptoms with patients older than 50 years, therapy lasted less. The difference averaged 4.1 months and was associated with a higher frequency in the older age group of vascular, metabolic and neurological disorders that slow down the regulatory processes of urination recovery.Conclusion. Alpha1-blockers and nootropics are pathogenetically substantiated for the treatment of imperative disorders of urination and urinary incontinence. Evaluation using the interval scale reliably demonstrates their high clinical effectiveness, persistence of the therapeutic effect and the feasibility of application at the stage of selection for surgical treatment.

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Imidafenacin for treatment of overactive bladder and urgent urinary incontinence: the results of open-label multicenter randomized controlled clinical trial

Cited by 2 publications

References 0 publications

Prevention of Postoperative Urethral Strictures by Irrigation with 5-Fluorouracil via a Modified Urinary Catheter

Prevention of Postoperative Urethral Strictures by Irrigation with 5-Fluorouracil via a Modified Urinary Catheter

Assessment of Efficiency of Combined Pharmacotherapy for Imperative and Mixed Urinary Disorders in Women With the Interval Scale

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