Imidazo[1,2-a]pyridine anthelmintic and antifungal agents

Fisher, Michael H.; Lusi, A

doi:10.1021/jm00279a026

Cited by 212 publications

(95 citation statements)

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“…The experimentally observed FTIR bands at 1275 cm -1 (medium) corresponds to this vibration. The experimental values at 201 cm -1 and 227 cm -1 were observed by Fischer and Cané, respectively [5,13]. Unfortunately we could not observe these bands in the experimental spectrum.…”

Section: Vibrational Frequencies and Assignmentsmentioning

confidence: 51%

“…This is because, their derivatives open a large area of research in medicinal chemistry. In particular, they act as cardiostimulators [2], inhibit gastric secretion [3], exhibit antibacterial [4] and fungicidal activities [5]. The classical synthesis of imidazo [1,2-a]pyridines involves the condensation of a-haloketones with 2-aminopyridines.…”

Section: Introductionmentioning

confidence: 99%

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FT-IR spectra, vibrational assignments, and density functional calculations of imidazo[1,2-a]pyridine molecule and its Zn(II) halide complexes

Yurdakul

Badoğlu

2009

Struct Chem

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The geometry, frequency, and intensity of the vibrational bands of imidazo[1,2-a]pyridine (which is abbreviated as impy) were obtained by the density functional theory (DFT) calculations with BLYP, B3LYP, and B3PW91 functionals and 6-31G(d) basis set. The optimized geometric bond lengths and bond angles are in good agreement with the available X-ray data. The infrared spectrum of imidazo[1,2-a]pyridine was computed by the DFT method in order to reproduce the vibrational wavenumbers and intensities with an accuracy, which allows reliable vibrational assignments. Total energy distribution and isotopic shifts have been calculated in order to help for the perfect assignment of the vibrational modes. The zinc halide complexes Zn(impy) 2 X 2 [X = Cl, Br, and I] have also been synthesized. The compounds were characterized using the elemental analysis, FT-IR spectra, and quantum chemical calculations. The geometry optimization of Zn(impy) 2 X 2 yields distorted tetrahedral environment around Zn ion.

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Section: Vibrational Frequencies and Assignmentsmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

FT-IR spectra, vibrational assignments, and density functional calculations of imidazo[1,2-a]pyridine molecule and its Zn(II) halide complexes

Yurdakul

Badoğlu

2009

Struct Chem

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“…Therefore, the MWI-mediated multicomponent reaction has constituted an especially attractive synthetic strategy for the rapid and efficient library generation. received considerable interest from the pharmaceutical industry because of their interesting therapeutic properties, 4 including antibacterial, 5 antifungal, 6 antiviral, 7 antiulcer, 8 and anti-inflammatory behavior. 9 They have also been characterized as selective cyclin-dependent kinase inhibitors, 10 calcium channel blockers, 11 β -amyloid formation inhibitors, 12 and benzodiazepine receptor agonists.…”

Section: Introductionmentioning

confidence: 99%

Microwave‐Assisted, One‐Pot Three Component Synthesis of 2‐Phenyl H‐imidazo[1,2‐α]pyridine

Motevalli

Yaghoubi

Mirzazadeh

2012

Journal of Chemistry

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“…They act as cardiostimulators [15], inhibit gastric secretion [16], exhibit antibacterial [17] and fungicidal [18] activities.…”

Section: Introduction Bmentioning

confidence: 99%

Quantum chemical studies on prototautomerism of 1H‐imidazo[4,5‐c]pyridine

Yurdakul

Badoğlu

2011

Int J of Quantum Chemistry

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ABSTRACT:The structural features of the 1H-imidazo [4,5-c]pyridine (ICPY) tautomers and homodimers of the most stable tautomers have been studied by quantum chemical methods. FTIR and Raman spectra of the ICPY were recorded in the range of 4000-60 cm À1 and 3500-5 cm À1 . The predominant tautomer among four possible isomers of ICPY were determined. The optimized geometries and vibrational frequencies of possible ICPY tautomers and dimers were computed by B3LYP/DFT method with 6-311þþG(d,p) and 6-31G(d) basis sets. All vibrational frequencies assigned in detail with the help of total energy distribution (TED) and isotopic shifts. ICPY dimeric forms were also characterized according to their hydrogen bonding interactions, and it has been found that the most stable ICPY homodimer establishes moderate strong NAH … N type hydrogen bond.1 H NMR, 13C NMR, and 15 N NMR properties have been calculated for all tautomeric forms using the gauge independent atomic orbital (GIAO) method.

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Imidazo[1,2-a]pyridine anthelmintic and antifungal agents

Cited by 212 publications

References 2 publications

FT-IR spectra, vibrational assignments, and density functional calculations of imidazo[1,2-a]pyridine molecule and its Zn(II) halide complexes

FT-IR spectra, vibrational assignments, and density functional calculations of imidazo[1,2-a]pyridine molecule and its Zn(II) halide complexes

Microwave‐Assisted, One‐Pot Three Component Synthesis of 2‐Phenyl H‐imidazo[1,2‐α]pyridine

Quantum chemical studies on prototautomerism of 1H‐imidazo[4,5‐c]pyridine

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