Imidazo[1,2-a]Pyridine Derivatives–Copper(II) Salts: Highly Effective In Situ Combination for Catecholase

Moutaouakil, Mohamed; Abdelmjid, Cherif; Roby, Othmane; Tighadouini, Saïd; Jamaleddine, Jamal; Saddik, Rafik

doi:10.1007/s42250-023-00650-2

Cited by 3 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained results unequivocally demonstrate the remarkable catalytic activities exhibited by the in situ formed combinations of L 1 ‐L 11 ligands with various copper salts. These combinations exhibited superior catalytic activities compared to numerous previous studies [57,58,59,60,61,62] . These findings underscore the distinctiveness of the L/M combinations and their potential significance in facilitating the oxidation of catechol.…”

Section: Resultssupporting

confidence: 52%

New Pyrazole‐Hydrazide Derivatives: Synthesis, Characterization, Highly Active Catecholase‐Like Catalyst, and Antibacterial Study

Roby,

Ouadghiri,

Moutaouakil

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

This captivating presents a detailed exploration of novel pyrazole‐hydrazide derivatives achieved through meticulous synthesis and characterization. A series of novel compounds were synthesized and characterized using a variety of spectroscopic techniques and hyphenated techniques, confirming their structures and purities with precision. Intriguingly, the combination of these synthesized pyrazole‐hydrazide derivatives ligands and copper (II) salts such as Cu(CH3COO)2, Cu(NO3)2, CuSO4, and CuCl2 at aerobic conditions demonstrated remarkable efficiency in catalyzing the oxidation of catechol to o‐quinone. Particularly noteworthy is the excellent rate of 401 μmol L−1 s−1 exhibited by the complex formed by ligand L6 and the metal salt Cu(CH3COO)2 in the oxidation of catechol to o‐quinone. Additionally, an investigation into the antibacterial activity of these compounds against diverse bacterial strains, including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, was conducted. Surprisingly, the results revealed a distinct absence of significant antibacterial efficacy in the tested pyrazole‐hydrazide derivatives. This study contributes to the understanding of pyrazole‐hydrazide derivatives, emphasizing their catalytic potential. The novel compounds presented herein can serve as a starting point for applications in various fields, thereby enriching the research and paving the way for future investigations.

show abstract

Section: Resultssupporting

confidence: 52%

New Pyrazole‐Hydrazide Derivatives: Synthesis, Characterization, Highly Active Catecholase‐Like Catalyst, and Antibacterial Study

Roby,

Ouadghiri,

Moutaouakil

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…Previous publications suggest that these mechanisms include the inhibition of crucial metabolic enzymes in the target microorganism, interference with cell wall synthesis, destruction of specific microbial cellular proteins, and alteration of normal cellular processes [18,30,44,47] . Furthermore, it has been discovered that heterocyclic compounds containing nitrogen, oxygen, and sulfur atoms, like those studied in this research, exhibit significant biological activities, particularly as antibacterial agents [18,40,41,47,48] . Furthermore, a significant correlation has been observed between the antibacterial and antifungal activity of the newly synthesized imines and their structure.…”

Section: Resultsmentioning

confidence: 68%

“…[18,30,44,47] Furthermore, it has been discovered that heterocyclic compounds containing nitrogen, oxygen, and sulfur atoms, like those studied in this research, exhibit significant biological activities, particularly as antibacterial agents. [18,40,41,47,48] Furthermore, a significant correlation has been observed between the antibacterial and antifungal activity of the newly synthesized imines and their structure. Enhanced activity was observed for imines with electron-rich R substituents, indicating improved inhibition of bacterial and fungal growth.…”

Section: Minimum Inhibitory Concentration (Mic)mentioning

confidence: 89%

“…Imidazopyridine derivatives are known for their significant antioxidant activity. [48] In this study, the antioxidant potential of the synthesized compounds (C 1 -C 15 ) was assessed in vitro using the DPPH and ABTS assays (Table 4), which evaluate the ability of compounds to scavenge free radicals and reduce their oxidative capacity (Table 5). [36] Ascorbic acid, the reference antioxidant, demonstrated remarkably high activity in the DPPH test, with an IC 50 value of 25.49 � 4.79 μM.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…[8][9][10] They exhibit diverse pharmacological activities, including anticancer, anti-inflammatory, antiulcer, analgesic, antiprotozoal, antipyretic, antiviral, and other activities. [11,12] Moreover, imidazo [1,2-a]pyridines have demonstrated efficacy in treating psychiatric disorders and autoimmune conditions, further expanding their medical applications. [13,14] The ability of imidazo [1,2-a]pyridines to interact with various targets, such as melatonin receptors, DNA alkylating agents, and activin-like kinase (ALK2), underscores their potential for developing new therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

Moutaouakil,

Roby

et al. 2024

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

This study presents the synthesis of a novel series of imine derivatives derived from imidazo[1,2‐a]pyridine as potential therapeutic agents. The imines were obtained by condensing 2‐(4‐bromophenyl)‐6‐chloroimidazo[1,2‐a]pyridine‐3‐carbaldehyde with primary amines, leading to high‐purity products that were characterized using various spectroscopic techniques. The compounds demonstrated promising in vitro antimicrobial activity against various bacteria, including Staphylococcus aureus and Escherichia coli, as well as fungi, such as Candida albicans, Saccharomyces cerevisiae, and Aspergillus brasiliensis. Furthermore, the antioxidant properties of the imine derivatives were evaluated using DPPH and ABTS techniques, and the IC50 values measured revealed their ability to scavenge free radicals. Overall, this study provides a valuable contribution to the field of pharmacology by synthesizing a new series of imine derivatives with significant potential as new therapeutic agents, exhibiting both antimicrobial and antioxidant properties.

show abstract

Investigating catalytic pathways: a comparative review of homogeneous and heterogeneous catalysis for 3-aroylimidazo[1,2-a]pyridine synthesis

Moutaouakil,

Roby,

Tighadouini

et al. 2023

Mol Divers

View full text Add to dashboard Cite

Imidazo[1,2-a]Pyridine Derivatives–Copper(II) Salts: Highly Effective In Situ Combination for Catecholase

Cited by 3 publications

References 52 publications

New Pyrazole‐Hydrazide Derivatives: Synthesis, Characterization, Highly Active Catecholase‐Like Catalyst, and Antibacterial Study

New Pyrazole‐Hydrazide Derivatives: Synthesis, Characterization, Highly Active Catecholase‐Like Catalyst, and Antibacterial Study

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

Investigating catalytic pathways: a comparative review of homogeneous and heterogeneous catalysis for 3-aroylimidazo[1,2-a]pyridine synthesis

Contact Info

Product

Resources

About