Imidazo(1,2-a)pyridines. II. Ozonolysis of Imidazo(1,2-a)pyridines and Synthesis of Cardiotonic Agents.

Synthesis of 2,3-dihydroimidazo[1,2-a]-pyridines and their salts. (review)

“…[40,52,91,[105][106][107][108][109]. For example, the compound XXVI is converted into imidazopyridinium hydrobromide XXVII even at room temperature [ 110].…”

Photochemical regioselective C–H arylation of imidazo[1,2-a]pyridine derivatives using chlorophyll as a biocatalyst and diazonium salts

“…9 Hence, colossal endeavors have been devoted to the use of distinctive imidazo[1,2- a ]pyridines to explore their therapeutic potential. 10 A portion of their derivatives are involved in the central nervous system 11 and have cardiotonic, 12 antiseptic, 13 anti-inflammatory, 14 and analgesic effects, 15 and they also show activity against HIV infections. 16 Imidazo[1,2- a ]pyridine compounds are currently in clinical use, for instance, zolimidine (an antiulcer gastroprotective drug), 17 zolpidem (a sedative/hypnotic medication), and alpidem (a non-narcotic anxiolytic medication) (Scheme 1).…”

Synthesis and molecular structure of 3-(2-aryl-2-oxoethyl)-3-methoxy-2-oxo-2,3-dihydroimidazo-[1,2-a]pyridine hydrochlorides

“…Some of their derivatives act on the central nervous system [1,2] and have cardiotonic [3], antiseptic [4,5], anti-inflammatory, and analgesic [6] effects, and also show activity against HIV infections [7]. This paper continues research in the synthesis of imidazo[1,2-a]-pyridine derivatives and the search for biologically active compounds in that series [8], for which we have examined the reactions of N-(2-pyridyl)amides of Z-4-aryl-2-hydroxy-4-oxobut-2-enoic acids 1a-e with diazomethane.…”