Imidazole and benzimidazole N-oxides (review)

Никитина, Г. В.; Pevzner, M. S.

doi:10.1007/bf00531655

Cited by 31 publications

(21 citation statements)

References 59 publications

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“…Imidazole and imidazole N-oxide derivatives synthesis have been extensively reviewed [11,12]. There is a variety of methods to obtain imidazole derivatives but few have a general application.…”

Section: 1-imidazole and Imidazole N-oxidementioning

confidence: 99%

Imidazole and Benzimidazole Derivatives as Chemotherapeutic Agents

Boiani¹,

González

2005

MRMC

422

198

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Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.

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Section: 1-imidazole and Imidazole N-oxidementioning

confidence: 99%

Imidazole and Benzimidazole Derivatives as Chemotherapeutic Agents

Boiani¹,

González

2005

MRMC

422

198

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“…The mechanism involves initial nucleophilic attack at the annular nitrogen of the benzofuroxan. [54,301,303] Strong alkylating agents such as nitroalkanes and alkyl trifluoromethanesulfonates give 2-alkyl-1-hydroxybenzimidazole 3-oxides, as do benzenesulfonic acid and phenylsulfonylacetophenone. This is, however, an oversimplification because the nitroso groups can act as either electron acceptors or donors.…”

Section: Methods 2: From Benzoxazolesmentioning

confidence: 99%

Product Class 4: Benzimidazoles

Neier¹,

Bellus²

2002

Category 2, Hetarenes and Related Ring Systems

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“…-4, 4-dimethyl. 2-pbenyl-5-( 2- (12). A saturated solution of H2S (50 mL) in MeOH was added to a solution of imidaz01ine 5 (I g, 4.3 mmot) in 10 mL of MeOH.…”

Section: Nitronylnitroxyl Radicals 10b--d (General Procedure) Leadmentioning

confidence: 99%