Imidazole Derivatives. XXX. Synthesis and Antitumor Activity of 4-amyloxy-3-nitroacetophenone 2-imidazolinyl-2-hydrazone and Related Compounds

Iradyan, M. A.; Aroyan, R. A.; Stepanyan, G. M.; Arsenyan, F. G.; Garibdzhanyan, B. T.

doi:10.1007/s11094-008-0133-7

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…3-Nitroacetophenone (3-NAP) is a compound used as Biofield Treated 3-Nitroacetophenone intermediate for the synthesis of flurbiprofen that is administered for the treatment of inflammation and arthritis pain [5]. Iradyan et al synthesized 3-NAP derivatives and investigated its antitumor efficiency [6]. Chalcones are an important class of compounds associated with excellent pharmacological activity [7].…”

Section: Introductionmentioning

confidence: 99%

Physical, Thermal and Spectral Properties of Biofield Treated 3-Nitroacetophenone

Trivedi¹

2015

SJAC

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3-Nitroacetophenone (3-NAP) is an organic compound used as an intermediate for the synthesis of pharmaceutical agents. The aim of this study was to evaluate the impact of biofield energy treatment on the physical, thermal and spectral properties of 3-NAP. The study was performed in two groups i.e. control and treated. The control group remained as untreated, and the treated group received Mr. Trivedi's biofield energy treatment. The control and treated 3-NAP samples were further characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), laser particle size analyzer, surface area analyzer, Fourier transform infrared (FT-IR) spectroscopy, and ultra violet-visible spectroscopy (UV-vis) analysis. The XRD analysis showed decrease in crystallite size of treated 3-NAP by 20.27% as compared to the control sample. However, the XRD peaks of treated sample showed an increase in intensity as compared to the control. The DSC result showed a slight increase in melting temperature of treated 3-NAP (80.75ºC) with respect to the control (79.39ºC). The latent heat of fusion of treated 3-NAP was changed by 16.28% as compared to the control sample. The TGA analysis showed an increase in onset temperature of treated sample (192ºC) as compared to the control sample (182ºC). Further, the maximum thermal decomposition temperature (T max ) of treated 3-NAP was increased as compared to the control. This showed the increase in thermal stability of treated 3-NAP with respect to control. The treated 3-NAP showed an increase in average particle size (d 50 ) by 27.6% along with an increase in size exhibited by 99% of particles (d 99 ) by 4.9% as compared to the control. Brunauer-Emmett-Teller (BET) analysis showed a substantial decrease in surface area by 24.6% with respect to the control. The FT-IR analysis showed an emergence of peak at 1558 cm -1 in treated 3-NAP sample as compared to the control. Nevertheless, the UV spectral analysis of treated 3-NAP showed no alterations in absorption peaks as compared to the control. Altogether, the result showed that biofield energy treatment has altered the physical, thermal and spectral properties of treated 3-NAP as compared to the control.

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Section: Introductionmentioning

confidence: 99%

Physical, Thermal and Spectral Properties of Biofield Treated 3-Nitroacetophenone

Trivedi¹

2015

SJAC

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Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives

et al. 2013

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Thirteen 2-[2-(5-methyl-2-benzoxazolinone-3-yl)acetyl]-3/4/5-substituted benzylidenehydrazine derivatives were synthesized by reacting 2-(5-methyl-2-benzoxazolinone-3-yl)acetylhydrazine and substituted benzaldehydes in neutral and acid/base catalyzed conditions, and a comparison was made in terms of their yields and reaction times. The structures of all compounds were confirmed by IR, (1)H NMR, (13)C NMR, mass spectral data, and elemental analyses. All the compounds were investigated for their ability to selectively inhibit MAO isoforms by in vitro tests and were found to inhibit recombinant human MAO-B selectively and reversibly in a competitive manner. Among the compounds examined, compound 16 was found to be more selective than selegiline, a known MAO-B inhibitor, in respect to the K i values experimentally found. Additionally, compounds 9 and 15 showed moderate MAO-B inhibitor activity. The interaction of compounds with MAO isoforms was investigated by molecular docking studies using recently published crystallographic models of MAO-A and MAO-B. The results obtained from the docking studies were found to be in good agreement with the experimental values.

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Synthesis, Protistocidal and Antibacterial Activities of 2′-Imidazolinylhydrazones of Mono- and Dicarboxylic Acids

et al. 2015

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Imidazole Derivatives. XXX. Synthesis and Antitumor Activity of 4-amyloxy-3-nitroacetophenone 2-imidazolinyl-2-hydrazone and Related Compounds

Abstract: The antitumor properties of 2-imidazolinyl-2-hydrazones of acetophenones with various substituents in the benzene ring have been studied. High activity is found for 4-amyloxy-3-nitroacetophenone 2-imidazolinyl-2-hydrazone, which points to the expediency of its further investigation.

Cited by 5 publications

References 3 publications

Physical, Thermal and Spectral Properties of Biofield Treated 3-Nitroacetophenone

Physical, Thermal and Spectral Properties of Biofield Treated 3-Nitroacetophenone

Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives

Synthesis, Protistocidal and Antibacterial Activities of 2′-Imidazolinylhydrazones of Mono- and Dicarboxylic Acids

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