2022
DOI: 10.2174/1871520621666210727113639
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Imidazolidine Derivatives in Cancer Research: What is known?

Abstract: : Even though cancer is the second leading cause of death globally, a number of open issues persist in cancer treatment, despite the achievements of the field. This review aims at discussing the fundamental role of Imidazolidine derivatives in the industry of cancer treatment. Compelling data from 1996 to 2021 will introduce Imidazolidine derivatives as a relevant tool to modulate cancer progression.

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Cited by 3 publications
(10 citation statements)
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“…Product 1a was identified by comparison with the NMR data of pure compound 2a obtained later. Compound 1a: 1 H NMR (400 MHz, CDCl 3 ) δ: 3.29 (s, 6H, H2, H4, H6), 2.96 (t, 6H, J = 7.0 Hz, H8), 2.50 (t, 6H, J = 7.0 Hz, H7), 3.40 (s br, 3H, H9), 2.25 (s, 9H, H10). 13 C NMR (101 MHz, CDCl 3 ) δ: 72.3 (C2, C4, C6), 54.2 (C7), 45.7 (C8), 39.5 (C10).…”
Section: General Experimental Detailsmentioning
confidence: 99%
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“…Product 1a was identified by comparison with the NMR data of pure compound 2a obtained later. Compound 1a: 1 H NMR (400 MHz, CDCl 3 ) δ: 3.29 (s, 6H, H2, H4, H6), 2.96 (t, 6H, J = 7.0 Hz, H8), 2.50 (t, 6H, J = 7.0 Hz, H7), 3.40 (s br, 3H, H9), 2.25 (s, 9H, H10). 13 C NMR (101 MHz, CDCl 3 ) δ: 72.3 (C2, C4, C6), 54.2 (C7), 45.7 (C8), 39.5 (C10).…”
Section: General Experimental Detailsmentioning
confidence: 99%
“…Product 1c was identified by comparison with the NMR data of pure compound 2c obtained later. Compound 1c: 1 H NMR (400 Mhz, CDCl 3 ) δ: 7.35-7.15 (m, 15H, H ar ), 3.59 (s, 6H, H10), 3.42 (s, 6H, H2, H4, H6), 3.02 (t, 6H, J = 7.1 Hz, H8), 2.62 (t, 6H, J = 7.1 Hz, H7), 2.60 (s br, 3H, H9). 13 C NMR (101 MHz, CDCl 3 ) δ: 139.0 (C i ), 128.7 (C o ), 128.5 (C m ), 127.2 (C p ), 70.7 (C2, C4, C6), 58.0 (C10), 52.3 (C7), 45.4 (C8).…”
Section: General Experimental Detailsmentioning
confidence: 99%
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“…This discussion will encompass the nuances of structure-activity relationships, providing a rational framework for interpreting observed biological activities. [19,20] This review seeks to provide a holistic view of the use of imidazolidinone derivatives as pioneering anticancer agents. By unraveling insights from their synthesis to structure-activity exploration, we aim to contribute valuable knowledge to the field of medicinal chemistry, guiding future research endeavors toward the development of innovative and effective anticancer therapeutics.…”
Section: Introductionmentioning
confidence: 99%
“…As we explore the in vitro anticancer activities of imidazolidinone derivatives, a comprehensive understanding of their efficacy in different cancer cell lines and animal models will be presented. This discussion will encompass the nuances of structure‐activity relationships, providing a rational framework for interpreting observed biological activities [19,20] . This review seeks to provide a holistic view of the use of imidazolidinone derivatives as pioneering anticancer agents.…”
Section: Introductionmentioning
confidence: 99%