Imidazolium salts with antifungal potential for the control of head blight of wheat caused by <i>Fusarium graminearum</i>

Ribas, Aícha Daniela Ribas e; Ponte, Emerson M. Del; Dalbem, A.M.; Dalla‐Lana, D.; Bündchen, Cristiane; Donato, Ricardo K.; Schrekker, Henri Stephan

doi:10.1111/jam.13125

Cited by 18 publications

(14 citation statements)

References 39 publications

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“…In this study, we have chosen imidazolium ionic liquids with three different alkyl groups for determining (i) biofilm prevention and biofilm eradication activities on C. albicans strains and (ii) mode of action of promising ionic liquid on C. albicans cells. Although antifungal and antibiofilm activities of imidazolium ionic liquids have been studied previously (Bergamo et al, 2014Dalla Lana et al, 2015;Ribas et al, 2016), their effects on preformed C. albicans biofilms and their molecular toxicity mechanisms are largely unknown. This study provided a clear insight into the biofilm eradication potential of alkylimidazolium ionic liquids and mechanism of action of prospective antifungal ionic liquid.…”

Section: Discussionmentioning

confidence: 99%

“…Activity of -hexadecyl side chain containing imidazolium ionic liquid against multidrug resistant Candida tropicalis and clinical dermatophyte strains showed potential activity against biofilms (Bergamo et al, 2014Dalla Lana et al, 2015). Inhibition of conidia germination and mycelial growth was observed in Fusarium graminearum (Ribas et al, 2016). Antifungal ionic liquids were incorporated into poly(L-lactide) biomaterials for inhibiting adhesion of Candida spp.…”

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confidence: 99%

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Alkylimidazolium Ionic Liquids as Antifungal Alternatives: Antibiofilm Activity Against Candida albicans and Underlying Mechanism of Action

Reddy

Nancharaiah

2020

Front. Microbiol.

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Frontiers in Microbiology | www.frontiersin.org 1 April 2020 | Volume 11 | Article 730Reddy and Nancharaiah Antifungal Imidazolium Ionic Liquids metabolic activity (measured by MTT assay). This study demonstrated that imidazolium ionic liquid compound exert antifungal and antibiofilm activity by affecting various cellular processes. Thus, imidazolium ionic liquids represent a promising antifungal treatment strategy in lieu of resistance development to common antifungal drugs.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Alkylimidazolium Ionic Liquids as Antifungal Alternatives: Antibiofilm Activity Against Candida albicans and Underlying Mechanism of Action

Reddy

Nancharaiah

2020

Front. Microbiol.

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“…; Ribas et al . ). They showed evidence to interfere in the ergosterol synthesis, one of the main sterols of the fungal cell membrane; however, the mechanism seems to be much more complex, and further investigations are necessary.…”

Section: Strategies To Combat Fungal Resistancementioning

confidence: 97%

Antifungals discovery: an insight into new strategies to combat antifungal resistance

Fuentefría

Pippi

Lana

et al. 2018

Letters in Applied Microbiology

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149

109

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Significance and Impact of the Study: The failure to respond to antifungal therapy is complex and is associated with microbiological resistance and increased expression of virulence in fungal pathogens. Thus, this review offers an overview of current challenges in the treatment of fungal infections associated with increased antifungal drug resistance and the formation of biofilms in these opportunistic pathogens. Furthermore, the most recent and potential strategies to combat fungal pathogens are explored here, focusing on new agents as well as innovative approaches, such as combination therapy between antifungal drugs or with natural compounds. AbstractUndeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal infections have significantly increased in recent decades, being highlighted as important causes of morbidity and mortality, particularly in immunocompromised patients. Five main antifungal classes are used: (i) azoles, (ii) echinocandins, (iii) polyenes, (iv) allylamines and (v) pyrimidine analogues. Moreover, the treatment of mycoses has several limitations, such as undesirable side effects, narrow activity spectrum, a small number of targets and fungal resistance, which are still of major concern in clinical practice. The discovery of new antifungals is mostly achieved by the screening of natural or synthetic/semisynthetic chemical compounds. The most recent discoveries in drug resistance mechanism and their avoidance were explored in a review, focusing on different antifungal targets, as well as new agents or strategies, such as combination therapy, that could improve antifungal therapy.

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“…Later, the same group examined the effect of the imidazolium salts on the phytopathogen F. gramineraum . 156 They observed that the antifungal activity was mostly modulated by that the counter ion. Another molecule containing long linear alkyl chains is phosphatidylethanolamine.…”

Section: New Antifungal Leadsmentioning

confidence: 99%

A complex game of hide and seek: the search for new antifungals

2016

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Fungal infections directly affect millions of people each year. In addition to the invasive fungal infections of humans, the plants and animals that comprise our primary food source are also susceptible to diseases caused by these eukaryotic microbes. The need for antifungals, not only for our medical needs, but also for use in agriculture and livestock causes a high demand for novel antimycotics. Herein, we provide an overview of the most commonly used antifungals in medicine and agriculture. We also present a summary of the recent progress (from 2010–2016) in the discovery/development of new agents against fungal strains of medical/agricultural relevance, as well as information related to their biological activity, their mode(s) of action, and their mechanism(s) of resistance.

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Imidazolium salts with antifungal potential for the control of head blight of wheat caused by Fusarium graminearum

Abstract: This study suggests the potential of using IMS as alternative to the hazardous standard fungicides in the management of Fusarium head blight of wheat.

Cited by 18 publications

References 39 publications

Alkylimidazolium Ionic Liquids as Antifungal Alternatives: Antibiofilm Activity Against Candida albicans and Underlying Mechanism of Action

Alkylimidazolium Ionic Liquids as Antifungal Alternatives: Antibiofilm Activity Against Candida albicans and Underlying Mechanism of Action

Antifungals discovery: an insight into new strategies to combat antifungal resistance

A complex game of hide and seek: the search for new antifungals

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