Imidazopyridine, a promising scaffold with potential medicinal applications and structural activity relationship (SAR): recent advances

Khatun, Samima; Singh, Amarjot; Bader, Ghulam Nabi; Sofi, Firdoos Ahmad

doi:10.1080/07391102.2021.1997818

Cited by 31 publications

(10 citation statements)

References 147 publications

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“…This heterocyclic system serves as a crucial pharmacophore motif, expanding medicinal chemistry tools. Additionally, imidazopyridines find use in combating helminthic, coccidial, and fungal infections, illustrating their multifaceted role in drug development [53]. Recently, imidazopyridine derivatives are reported to have potential for anti-trypanosomiases drug discovery.…”

Section: Discussionmentioning

confidence: 99%

Selenium-Containing (Hetero)Aryl Hybrids as Potential Antileishmanial Drug Candidates: In vitro Screening Against L. amazonensis

Fermiano,

Das Neves,

Da Silva

et al. 2023

Preprint

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Leishmaniasis remains a significant global health concern, with current treatments relying on outdated drugs associated with high toxicity, lengthy administration, elevated costs, and drug resistance. Consequently, the urgent need for safer and more effective therapeutic options in leishmaniasis treatment persists. Previous research has highlighted selenium compounds as promising candidates for innovative leishmaniasis therapy. In light of this, a library of 10 selenium-containing diverse compounds was designed and evaluated in this study. The compounds were subjected to screening against L. amazonensis promastigotes, and their cytotoxicity was assessed in NIH/3T3 cells. Among the tested compounds, MRK-106 and MRK-108 displayed the highest potency against L. amazonensis promastigotes while demonstrating reduced cytotoxicity. Notably, MRK-106 and MRK-108 exhibited IC50 values of 3.97 µM, 4.23 µM, respectively, and most of the tested compounds showed low cytotoxicity in NIH/3T3 cells (CC50 &gt; 200 µM). Although these results are promising, additional investigations focusing on intracellular amastigotes are required to determine the antileishmanial activity of the compounds. In conclusion, the identified selenium-containing compounds hold considerable potential as antileishmanial drug candidates and warrant further exploration in subsequent studies. These findings represent a significant step towards the development of safer and more effective therapies for leishmaniasis, addressing the pressing need for novel and improved treatments.

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Section: Discussionmentioning

confidence: 99%

Selenium-Containing (Hetero)Aryl Hybrids as Potential Antileishmanial Drug Candidates: In vitro Screening Against L. amazonensis

Fermiano,

Das Neves,

Da Silva

et al. 2023

Preprint

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“…Imidazopyridines, fused-ring systems composed of an imidazole and a pyridine ring, exhibit diverse pharmacological activities due to their ability to interact with specific molecular targets and modulate physiological pathways. 105 Consequently, the synthesis of functionalised imidazopyridines is highly important. Compared with the transition metal-catalysed method, light-induced direct C–H trifluoromethylation of imidazopyridines is more environmentally friendly and sustainable.…”

Section: Photoredox Approachmentioning

confidence: 99%

Harnessing photocatalytic and electrochemical approaches for C–H bond trifluoromethylation and fluoroalkylation

Shaw,

Sihag,

Bhartiya

et al. 2024

Org. Chem. Front.

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Section: Imidazopyrimidines As Anticancer Agentsmentioning

confidence: 99%

“…The synthesis and pharmacological research of heteroatomic chemical molecules, such as imidazopyridines 41 exhibiting potential anticancer activity, have attracted much attention recently. 42 A wide range of antiproliferative actions was demonstrated by benzimidazole pharmacophores such as bis(benzimidazole) Hoechst 33258, which also bound to DNA minor grooves and inhibited topoisomerase activity. 43 The binding patterns of nocodazole and colchicine at the tubulin αβ interface are analogous.…”

Section: Tubulin Inhibitorsmentioning

confidence: 99%

Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery

Chowdhury,

Kalmegh,

Kapoor

et al. 2024

RSC Med. Chem.

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Imidazopyridine, a promising scaffold with potential medicinal applications and structural activity relationship (SAR): recent advances

Cited by 31 publications

References 147 publications

Selenium-Containing (Hetero)Aryl Hybrids as Potential Antileishmanial Drug Candidates: In vitro Screening Against L. amazonensis

Selenium-Containing (Hetero)Aryl Hybrids as Potential Antileishmanial Drug Candidates: In vitro Screening Against L. amazonensis

Harnessing photocatalytic and electrochemical approaches for C–H bond trifluoromethylation and fluoroalkylation

Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery

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