Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review

Exploring the untapped pharmacological potential of imidazopyridazines

“…The biological and pharmacological properties of these analogs differ signicantly depending on their specic structure and the substitutions on the core moieties and have been reviewed thoroughly. [61][62][63][64][65] Fig. 15 Imidazopyridazine moiety in approved and investigational drugs.…”

Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery

“…The synthesis and pharmacological research of heteroatomic chemical molecules, such as imidazopyridines 41 exhibiting potential anticancer activity, have attracted much attention recently. 42…”

“…The synthesis and pharmacological research of heteroatomic chemical molecules, such as imidazopyridines 41 exhibiting potential anticancer activity, have attracted much attention recently. 42 A wide range of antiproliferative actions was demonstrated by benzimidazole pharmacophores such as bis(benzimidazole) Hoechst 33258, which also bound to DNA minor grooves and inhibited topoisomerase activity.…”

Frustrated Lewis pairs in two-dimensional borocarbonitride for the facile synthesis of 3-aminoimidazo[1,2-α]pyridines using TMSCN as an isonitrile substitute

“…Imidazo[1,2-α]pyridines find an upper hand in the field of medicinal chemistry and they possess a wide range of biological activities including antibacterial, 1 anti-inflammatory, 2 antituberculosis, 3 and anticancer activities. 4 In addition, they are the potent inhibitors of gastric acid secretion, 5 GABAA receptor modulators, 6 and TRPM2-specific inhibitors. 7 Several imidazo [1,2-α]pyridine-based drug molecules are available on the market, including zolimidine (antiulcer drug), zolpidem (hypnotic drug) and alpidem (a nonsedative anxiolytic) (Fig.…”