Imipramine Poisoning in Childhood

Cardiovascular Complications of Tricyclic Antidepressant Overdosage

“…Some 50 to 60 % of the patients presenting with tricyclic overdosage have consumed only small amounts of the drug and these 'suicide gestures', while requiring psychiatric attention, do not pose any problems of medical management. It should be emphasised, however, that small doses, of the range of 75 to 100 mg, may produce dangerous side-effects in infants, and a fatality has been recorded with 350 mg of imipramine (Giles, 1963). Other patients who require careful observation for possible cardiovascular complications are those who take small overdoses of the tricyclics while on treatment with monoamine oxidase inhibitors, or antihypertensive drugs whichproduce catecholamine depletion, such as guanethidine (Williams and Sherter, 1971).…”

Types of psychiatric treatment. Drug treatment.

“…Childproof containers are essential. 34 Sleep deprivation or deprivation of rapid eye movement sleep as treatments for depression have yielded inconsistent results but may offer a treatment alternative for antidepressant resistant patients. 35 36 Very severe depressive illness unresponsive to antidepressants, depressive stupor, and catatonic stupor are rare indications for electroconvulsive treatment.…”

Cardiovascular Abnormalities following Tricyclic Antidepressant Drug Overdosage

“…Differentiation from ventricular tachycardia may be difficult. Physostigmine, administered intravenously (a total of I to 3 mg in divided doses) has been reported to be effective in the management of supraventricular tachycardia following tricyclic overdosage [10] .…”