Imiquimod 5% cream is an acceptable treatment option for external anogenital warts in uncircumcised males

Maw, R D; Kinghorn, G R; Bowman, Christine; Goh, B T; Nayagam, AT; Nathan, Mayura

doi:10.1046/j.1468-3083.2002.00366.x

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…In general, the patients with more difficult warts are more likely to receive additional therapy. Multiplicity and the total treatment period were thought to reflect the therapeutic difficulties21. To take into account the therapeutic difficulties, such as the number of lesions and the treatment period, covariant analysis was performed in this study.…”

Section: Discussionmentioning

confidence: 99%

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Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy?

2011

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BackgroundCryotherapy has been accepted as the mainstay in treating periunugal and palmoplantar warts. The major drawback of cryotherapy is the requirement of several unbearably painful treatment sessions.ObjectiveThis study aims to assess the efficacy of immunotherapy in viral wart treatment, as an adjunctive method to cryotherapy.MethodsRetrospective chart review was performed on 124 patients visiting the hospital from January to December 2009 for the treatment of periungual and plantar warts. We analyzed the number of cryotherapy sessions necessary for treating warts and assessed the clinical benefits from the addition of other treatment modalities, by adjusting the various confounding factors.ResultsOf the 124 investigated patients, immunotherapy with diphenylcyclopropenone (DPCP) was performed in 14 patients (11%), together with cryotherapy. After adjusting the factors related to the therapeutic difficulties of wart, the average number of cryotherapy sessions for the immunotherapy-combined group was significantly lower (3.58±1.25) than that for the cryotherapy only group (5.10±0.44) (p=0.026). However, there were no differences in the number of treatment sessions of cryotherapy when topical 5-FU/salicylic acid agents were added to the treatment.ConclusionImmunotherapy may be a successful adjuvant to cryotherapy in reducing the number of agonizing cryotherapy sessions.

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Section: Discussionmentioning

confidence: 99%

“…cryogen spray versus cotton ball application) and treatment intervals2. When the spray gun is used, it is held perpendicular to the wart at a distance of 1~2 cm and liquid nitrogen is sprayed until the ice ball has spread from the center to include the edge of the wart and a 2 mm margin21. The lesion is then allowed to thaw.…”

Section: Discussionmentioning

confidence: 99%

Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy?

2011

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“…A more restricted total wart area probably represents a reduced viral load and predicts a favourable response. The clearance of genital warts has been related before to the size and number of lesions 5–7 . However, other authors have not found an association between the number of anogenital warts and the clinical outcome 8 …”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for the response to treatment in males with genital warts

Stefanaki

Hadjivassiliou

Katzouranis

et al. 2009

Acad Dermatol Venereol

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“…25 More restricted total wart area probably represents a reduced viral load and predicts a favourable response. However, the data from the literature are contradictory; because whereas some investigators have found an association between the clearance of genital warts and the size and number of lesions, 26 …”

Section: Discussionmentioning

confidence: 99%

Atopic patients with genital warts have a more protracted clinical course and a greater probability of recurrences

Stefanaki

Verra

et al. 2010

Int J STD AIDS

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The factors predicting an unfavourable response of genital warts to treatment have not been determined. The disease characteristics were recorded for 390 patients with genital warts and treated by cryotherapy. The time to achieve clearance was recorded. A personal and family history of asthma, hay fever or eczema, as well as a personal history of common warts and number of recurrences was obtained by telephone four to five years after the clinical visits. In multiple regression analysis, the number of lesions (P < 0.001), extent of the disease (P = 0.003) and personal history of atopy (P = 0.001) were found to influence the time until response to treatment. Similar results were obtained for family history of atopy. The number of sexual partners (P = 0.007), extent of the disease (P = 0.009) and personal history of atopy (P < 0.001) were the main factors influencing the probability of recurrence in multiple logistic regression. The results for family history of atopy were again similar. The study concludes that atopy is a major factor influencing the time frame of the therapeutic response and the probability of recurrence in patients with genital warts.

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Imiquimod 5% cream is an acceptable treatment option for external anogenital warts in uncircumcised males

Abstract: Imiquimod cream at a dosing regimen of three times per week, is effective and has an acceptable safety profile in the treatment of prepuce associated warts and other external anogenital warts in uncircumcised males.

Cited by 10 publications

References 19 publications

Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy?

Does Immunotherapy of Viral Warts Provide Beneficial Effects When It Is Combined with Conventional Therapy?

Prognostic factors for the response to treatment in males with genital warts

Atopic patients with genital warts have a more protracted clinical course and a greater probability of recurrences

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